Limits...
ArteFill permanent injectable for soft tissue augmentation: II. Indications and applications.

Lemperle G, Sadick NS, Knapp TR, Lemperle SM - Aesthetic Plast Surg (2009)

Bottom Line: Patients ask for procedures with long-lasting effects.Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products.Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. glemperle@aol.com

ABSTRACT
Patients ask for procedures with long-lasting effects. ArteFill is the first permanent injectable approved in 2006 by the FDA for nasolabial folds. It consists of cleaned microspheres of polymethylmethacrylate (PMMA) suspended in bovine collagen. Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products. A 5-year follow-up study in U.S. clinical trial patients has shown the same wrinkle improvement as seen at 6 months. Long-term follow-up in European Artecoll patients has shown successful wrinkle correction lasting up to 15 years. A wide variety of off-label indications and applications have been developed that help the physician meet the individual needs of his/her patients. Serious complications after ArteFill injections, such as granuloma formation, have not been reported due to the reduction of PMMA microspheres smaller than 20 microm to less than 1% "by the number." Minor technique-related side effects, however, may occur during the initial learning curve. Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

Show MeSH

Related in: MedlinePlus

The nasolabial fold can be divided in three regions: The upper subnasal triangle must be treated with a fanning technique. The corners of the mouth and marionette lines are treated with a superficial criss-crossing technique ([2] with permission from Elsevier)
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2872008&req=5

Fig1: The nasolabial fold can be divided in three regions: The upper subnasal triangle must be treated with a fanning technique. The corners of the mouth and marionette lines are treated with a superficial criss-crossing technique ([2] with permission from Elsevier)

Mentions: Nasolabial creases are best supported by two to three bands of ArteFill implanted parallel and strictly medial to the fold (Fig. 1). ArteFill is still a viscous paste during the first 3 days after implantation and may be moved laterally by facial muscle movement. Care must be taken not to implant too superficially, i.e., intradermal, to prevent ridge formation. The subalar triangle should be leveled by fanlike injections (Figs. 1 and 2). If injected intradermally, the implant site may appear erythematous for several months and the implant may be visible in the form of little granules (Fig. 3). To avoid this technical error, strict implantation of ArteFill along the dermal-subdermal junction is essential [1, 4]. A second implantation is often necessary, especially in the lower third of the nasolabial crease adjacent to the corner of the mouth. Depending on the activity of facial muscle movement, the result may last for many years [3, 7] (Figs. 4, 5, 6, and 7).Fig. 1


ArteFill permanent injectable for soft tissue augmentation: II. Indications and applications.

Lemperle G, Sadick NS, Knapp TR, Lemperle SM - Aesthetic Plast Surg (2009)

The nasolabial fold can be divided in three regions: The upper subnasal triangle must be treated with a fanning technique. The corners of the mouth and marionette lines are treated with a superficial criss-crossing technique ([2] with permission from Elsevier)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2872008&req=5

Fig1: The nasolabial fold can be divided in three regions: The upper subnasal triangle must be treated with a fanning technique. The corners of the mouth and marionette lines are treated with a superficial criss-crossing technique ([2] with permission from Elsevier)
Mentions: Nasolabial creases are best supported by two to three bands of ArteFill implanted parallel and strictly medial to the fold (Fig. 1). ArteFill is still a viscous paste during the first 3 days after implantation and may be moved laterally by facial muscle movement. Care must be taken not to implant too superficially, i.e., intradermal, to prevent ridge formation. The subalar triangle should be leveled by fanlike injections (Figs. 1 and 2). If injected intradermally, the implant site may appear erythematous for several months and the implant may be visible in the form of little granules (Fig. 3). To avoid this technical error, strict implantation of ArteFill along the dermal-subdermal junction is essential [1, 4]. A second implantation is often necessary, especially in the lower third of the nasolabial crease adjacent to the corner of the mouth. Depending on the activity of facial muscle movement, the result may last for many years [3, 7] (Figs. 4, 5, 6, and 7).Fig. 1

Bottom Line: Patients ask for procedures with long-lasting effects.Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products.Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. glemperle@aol.com

ABSTRACT
Patients ask for procedures with long-lasting effects. ArteFill is the first permanent injectable approved in 2006 by the FDA for nasolabial folds. It consists of cleaned microspheres of polymethylmethacrylate (PMMA) suspended in bovine collagen. Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products. A 5-year follow-up study in U.S. clinical trial patients has shown the same wrinkle improvement as seen at 6 months. Long-term follow-up in European Artecoll patients has shown successful wrinkle correction lasting up to 15 years. A wide variety of off-label indications and applications have been developed that help the physician meet the individual needs of his/her patients. Serious complications after ArteFill injections, such as granuloma formation, have not been reported due to the reduction of PMMA microspheres smaller than 20 microm to less than 1% "by the number." Minor technique-related side effects, however, may occur during the initial learning curve. Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

Show MeSH
Related in: MedlinePlus