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ArteFill permanent injectable for soft tissue augmentation: II. Indications and applications.

Lemperle G, Sadick NS, Knapp TR, Lemperle SM - Aesthetic Plast Surg (2009)

Bottom Line: Patients ask for procedures with long-lasting effects.Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products.Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. glemperle@aol.com

ABSTRACT
Patients ask for procedures with long-lasting effects. ArteFill is the first permanent injectable approved in 2006 by the FDA for nasolabial folds. It consists of cleaned microspheres of polymethylmethacrylate (PMMA) suspended in bovine collagen. Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products. A 5-year follow-up study in U.S. clinical trial patients has shown the same wrinkle improvement as seen at 6 months. Long-term follow-up in European Artecoll patients has shown successful wrinkle correction lasting up to 15 years. A wide variety of off-label indications and applications have been developed that help the physician meet the individual needs of his/her patients. Serious complications after ArteFill injections, such as granuloma formation, have not been reported due to the reduction of PMMA microspheres smaller than 20 microm to less than 1% "by the number." Minor technique-related side effects, however, may occur during the initial learning curve. Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

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Related in: MedlinePlus

Lumps in the vermilion may occur when early muscle movement compresses material into a ball when mistakenly injected into the muscle into a ball
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Fig19: Lumps in the vermilion may occur when early muscle movement compresses material into a ball when mistakenly injected into the muscle into a ball

Mentions: ArteFill should never be implanted into the orbicularis oris muscle since this may cause dislocation and nodule formation (Fig. 19). The patient must be aware that submucosally implanted ArteFill can nearly always be felt with the tongue or the teeth and may appear white when the lip is stretched. Sensitivity to touch and kissing may last up to 1 year but usually resolves spontaneously.Fig. 19


ArteFill permanent injectable for soft tissue augmentation: II. Indications and applications.

Lemperle G, Sadick NS, Knapp TR, Lemperle SM - Aesthetic Plast Surg (2009)

Lumps in the vermilion may occur when early muscle movement compresses material into a ball when mistakenly injected into the muscle into a ball
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2872008&req=5

Fig19: Lumps in the vermilion may occur when early muscle movement compresses material into a ball when mistakenly injected into the muscle into a ball
Mentions: ArteFill should never be implanted into the orbicularis oris muscle since this may cause dislocation and nodule formation (Fig. 19). The patient must be aware that submucosally implanted ArteFill can nearly always be felt with the tongue or the teeth and may appear white when the lip is stretched. Sensitivity to touch and kissing may last up to 1 year but usually resolves spontaneously.Fig. 19

Bottom Line: Patients ask for procedures with long-lasting effects.Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products.Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. glemperle@aol.com

ABSTRACT
Patients ask for procedures with long-lasting effects. ArteFill is the first permanent injectable approved in 2006 by the FDA for nasolabial folds. It consists of cleaned microspheres of polymethylmethacrylate (PMMA) suspended in bovine collagen. Over the development period of 20 years most of its side effects have been eliminated to achieve the same safety standard as today's hyaluronic acid products. A 5-year follow-up study in U.S. clinical trial patients has shown the same wrinkle improvement as seen at 6 months. Long-term follow-up in European Artecoll patients has shown successful wrinkle correction lasting up to 15 years. A wide variety of off-label indications and applications have been developed that help the physician meet the individual needs of his/her patients. Serious complications after ArteFill injections, such as granuloma formation, have not been reported due to the reduction of PMMA microspheres smaller than 20 microm to less than 1% "by the number." Minor technique-related side effects, however, may occur during the initial learning curve. Patient and physician satisfaction with ArteFill has been shown to be greater than 90%.

Show MeSH
Related in: MedlinePlus