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Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions.

González L, Martin S, Hawkins SA, Goldmann W, Jeffrey M, Sisó S - Vet. Res. (2010)

Bottom Line: Unexpectedly, accumulation of disease-associated PrP (PrPd) in the brain was more frequent in methionine carriers at codon 142 (24/32, 75.0%) than amongst isoleucine homozygotes (14/40, 35.0%).The latter, however, showed significantly greater amounts of brain PrPd than the former (average scores of 9.3 and 3.0, respectively).These results, together with the early and consistent involvement of the circumventricular organs and the hypothalamus, point towards a significant contribution of the haematogenous route in the process of neuroinvasion.

View Article: PubMed Central - PubMed

Affiliation: Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, United Kingdom. l.gonzalez@vla.defra.gsi.gov.uk

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Magnitude of PrPd accumulation in the brain (y-axis; cumulative score of 10 areas examined) in relation to the number of LRS tissues affected (x-axis; superscripts refer to the number of brain-negative animals for each level of LRS positivity). (A) II142 goats; (B) IM/MM142 goats.
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Figure 1: Magnitude of PrPd accumulation in the brain (y-axis; cumulative score of 10 areas examined) in relation to the number of LRS tissues affected (x-axis; superscripts refer to the number of brain-negative animals for each level of LRS positivity). (A) II142 goats; (B) IM/MM142 goats.


Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions.

González L, Martin S, Hawkins SA, Goldmann W, Jeffrey M, Sisó S - Vet. Res. (2010)

Magnitude of PrPd accumulation in the brain (y-axis; cumulative score of 10 areas examined) in relation to the number of LRS tissues affected (x-axis; superscripts refer to the number of brain-negative animals for each level of LRS positivity). (A) II142 goats; (B) IM/MM142 goats.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865875&req=5

Figure 1: Magnitude of PrPd accumulation in the brain (y-axis; cumulative score of 10 areas examined) in relation to the number of LRS tissues affected (x-axis; superscripts refer to the number of brain-negative animals for each level of LRS positivity). (A) II142 goats; (B) IM/MM142 goats.
Bottom Line: Unexpectedly, accumulation of disease-associated PrP (PrPd) in the brain was more frequent in methionine carriers at codon 142 (24/32, 75.0%) than amongst isoleucine homozygotes (14/40, 35.0%).The latter, however, showed significantly greater amounts of brain PrPd than the former (average scores of 9.3 and 3.0, respectively).These results, together with the early and consistent involvement of the circumventricular organs and the hypothalamus, point towards a significant contribution of the haematogenous route in the process of neuroinvasion.

View Article: PubMed Central - PubMed

Affiliation: Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, United Kingdom. l.gonzalez@vla.defra.gsi.gov.uk

Show MeSH
Related in: MedlinePlus