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Solid Dispersion Matrix Tablet Comprising Indomethacin-PEG-HPMC Fabricated with Fusion and Mold Technique.

Mesnukul A, Yodkhum K, Phaechamud T - Indian J Pharm Sci (2009)

Bottom Line: This inert carrier system comprising 7:3 polyethylene glycol 4000: polyethylene glycol 400 could effectively enhance the solubility of indomethacin and an addition of hydroxypropylmethylcellulose could sustain the drug release.Least square fitting the experimental dissolution data to the mathematical expressions (power law, first-order, Higuchi's and zero-order) indicated the drug release kinetics primarily as Fickian diffusion.Both the enhancement of drug dissolution and the prolongation of the drug release could be achieved for aqueous insoluble drug such as, indomethacin, by using polyethylene glycol-hydroxypropylmethylcellulose matrix system prepared with melting and mold technique.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.

ABSTRACT
The purpose of this study is to fabricate the polyethylene glycol matrix tablet by mold technique. Indomethacin and hydroxypropylmethylcellulose were used as model drug and polymer, respectively, in PEG matrix system. The physical and drug release characteristics of developed matrix tablet were studied. This inert carrier system comprising 7:3 polyethylene glycol 4000: polyethylene glycol 400 could effectively enhance the solubility of indomethacin and an addition of hydroxypropylmethylcellulose could sustain the drug release. Scanning electron microscope photomicrograph indicated the drug diffusion outward through the porous network of this developed matrix tablet into the dissolution fluid. Least square fitting the experimental dissolution data to the mathematical expressions (power law, first-order, Higuchi's and zero-order) indicated the drug release kinetics primarily as Fickian diffusion. Both the enhancement of drug dissolution and the prolongation of the drug release could be achieved for aqueous insoluble drug such as, indomethacin, by using polyethylene glycol-hydroxypropylmethylcellulose matrix system prepared with melting and mold technique.

No MeSH data available.


SEM micrographs of tablets of 75 mg indomethacin.Scanning electron microscope micrographs of tablets containing 75 mg indomethacin and 25% HPMC in 70:30 PEG 4000:PEG 400 system after dissolution test in phosphate buffer pH 6.2 at different time interval with magnification of 250X.
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Figure 0007: SEM micrographs of tablets of 75 mg indomethacin.Scanning electron microscope micrographs of tablets containing 75 mg indomethacin and 25% HPMC in 70:30 PEG 4000:PEG 400 system after dissolution test in phosphate buffer pH 6.2 at different time interval with magnification of 250X.

Mentions: Micrographs of indomethacin powder are shown in fig. 6. Indomethacin was formed by plate crystals with smooth borders, but irregularly shaped and this morphology was retained also at small size. SEM images of tablet containing highest amount of HPMC exhibited the higher eroded surface with dissolution time and contained some pores after dissolution test at different time intervals (fig. 7).


Solid Dispersion Matrix Tablet Comprising Indomethacin-PEG-HPMC Fabricated with Fusion and Mold Technique.

Mesnukul A, Yodkhum K, Phaechamud T - Indian J Pharm Sci (2009)

SEM micrographs of tablets of 75 mg indomethacin.Scanning electron microscope micrographs of tablets containing 75 mg indomethacin and 25% HPMC in 70:30 PEG 4000:PEG 400 system after dissolution test in phosphate buffer pH 6.2 at different time interval with magnification of 250X.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC2865813&req=5

Figure 0007: SEM micrographs of tablets of 75 mg indomethacin.Scanning electron microscope micrographs of tablets containing 75 mg indomethacin and 25% HPMC in 70:30 PEG 4000:PEG 400 system after dissolution test in phosphate buffer pH 6.2 at different time interval with magnification of 250X.
Mentions: Micrographs of indomethacin powder are shown in fig. 6. Indomethacin was formed by plate crystals with smooth borders, but irregularly shaped and this morphology was retained also at small size. SEM images of tablet containing highest amount of HPMC exhibited the higher eroded surface with dissolution time and contained some pores after dissolution test at different time intervals (fig. 7).

Bottom Line: This inert carrier system comprising 7:3 polyethylene glycol 4000: polyethylene glycol 400 could effectively enhance the solubility of indomethacin and an addition of hydroxypropylmethylcellulose could sustain the drug release.Least square fitting the experimental dissolution data to the mathematical expressions (power law, first-order, Higuchi's and zero-order) indicated the drug release kinetics primarily as Fickian diffusion.Both the enhancement of drug dissolution and the prolongation of the drug release could be achieved for aqueous insoluble drug such as, indomethacin, by using polyethylene glycol-hydroxypropylmethylcellulose matrix system prepared with melting and mold technique.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.

ABSTRACT
The purpose of this study is to fabricate the polyethylene glycol matrix tablet by mold technique. Indomethacin and hydroxypropylmethylcellulose were used as model drug and polymer, respectively, in PEG matrix system. The physical and drug release characteristics of developed matrix tablet were studied. This inert carrier system comprising 7:3 polyethylene glycol 4000: polyethylene glycol 400 could effectively enhance the solubility of indomethacin and an addition of hydroxypropylmethylcellulose could sustain the drug release. Scanning electron microscope photomicrograph indicated the drug diffusion outward through the porous network of this developed matrix tablet into the dissolution fluid. Least square fitting the experimental dissolution data to the mathematical expressions (power law, first-order, Higuchi's and zero-order) indicated the drug release kinetics primarily as Fickian diffusion. Both the enhancement of drug dissolution and the prolongation of the drug release could be achieved for aqueous insoluble drug such as, indomethacin, by using polyethylene glycol-hydroxypropylmethylcellulose matrix system prepared with melting and mold technique.

No MeSH data available.