Limits...
Formulation and optimization of sustained release tablets of venlafaxine resinates using response surface methodology.

Madgulkar AR, Bhalekar MR, Kolhe VJ, Kenjale YD - Indian J Pharm Sci (2009)

Bottom Line: Compressed matrices exhibited the anomalous release mechanism, as the value of release rate exponent (n) varied between 08109 and 08719, resulting in regulated and complete release until 20 h.Validation of optimization study, performed using five confirmatory runs, indicated very high degree of prognostic ability of response surface methodology, with mean percentage error as 1.152+/-1.88%.Regulated drug release study indicates that the hydrophilic and hydrophobic matrix tablets of venlafaxine resinate prepared using hydroxypropylmethylcellulose and ethylcellulose, can successfully be employed as a once-a-day oral controlled release drug delivery system.

View Article: PubMed Central - PubMed

Affiliation: AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411 001, India.

ABSTRACT
The aim of the current study was to design sustained release matrix tablets of venlafaxine hydrochloride using ion exchange resin with the incorporation of hydrophilic and hydrophobic polymer combinations. Venlafaxine HCl was loaded onto Indion 244 by batch method and then resinate were wet granulated with ethyl cellulose and blended with hydroxypropylmethylcellulose and compressed. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profile at 2 h and at 18 h. Hydroxypropylmethylcellulose and ethylcellulose were taken as the independent variables. Response surface plots and contour plots were drawn, and optimum formulations were selected by feasibility and grid searches. Resinate shows inadequate sustained release profile. Compressed matrices exhibited the anomalous release mechanism, as the value of release rate exponent (n) varied between 08109 and 08719, resulting in regulated and complete release until 20 h. Validation of optimization study, performed using five confirmatory runs, indicated very high degree of prognostic ability of response surface methodology, with mean percentage error as 1.152+/-1.88%. Regulated drug release study indicates that the hydrophilic and hydrophobic matrix tablets of venlafaxine resinate prepared using hydroxypropylmethylcellulose and ethylcellulose, can successfully be employed as a once-a-day oral controlled release drug delivery system.

No MeSH data available.


Effect of pH of dissolution medium on drug release through DRCDRC is drug resin complex. 0.1 N HCl (); 7.2 pH PBS ().
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2865810&req=5

Figure 0003: Effect of pH of dissolution medium on drug release through DRCDRC is drug resin complex. 0.1 N HCl (); 7.2 pH PBS ().

Mentions: Studies carried out to establish effect of pH of dissolution medium onto drug release through the DRC showed no significant effect of pH on drug release through DRC (fig. 3). The assay content of venlafaxine HCl varied between 98.0 and 99.8%. Tablets weights varied between 448 and 452 mg, thickness between 4.5 to 6.5 mm, and hardness between 8.0 and 9.0 kg/cm2 and friability ranged between 0.3 and 0.6%.


Formulation and optimization of sustained release tablets of venlafaxine resinates using response surface methodology.

Madgulkar AR, Bhalekar MR, Kolhe VJ, Kenjale YD - Indian J Pharm Sci (2009)

Effect of pH of dissolution medium on drug release through DRCDRC is drug resin complex. 0.1 N HCl (); 7.2 pH PBS ().
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865810&req=5

Figure 0003: Effect of pH of dissolution medium on drug release through DRCDRC is drug resin complex. 0.1 N HCl (); 7.2 pH PBS ().
Mentions: Studies carried out to establish effect of pH of dissolution medium onto drug release through the DRC showed no significant effect of pH on drug release through DRC (fig. 3). The assay content of venlafaxine HCl varied between 98.0 and 99.8%. Tablets weights varied between 448 and 452 mg, thickness between 4.5 to 6.5 mm, and hardness between 8.0 and 9.0 kg/cm2 and friability ranged between 0.3 and 0.6%.

Bottom Line: Compressed matrices exhibited the anomalous release mechanism, as the value of release rate exponent (n) varied between 08109 and 08719, resulting in regulated and complete release until 20 h.Validation of optimization study, performed using five confirmatory runs, indicated very high degree of prognostic ability of response surface methodology, with mean percentage error as 1.152+/-1.88%.Regulated drug release study indicates that the hydrophilic and hydrophobic matrix tablets of venlafaxine resinate prepared using hydroxypropylmethylcellulose and ethylcellulose, can successfully be employed as a once-a-day oral controlled release drug delivery system.

View Article: PubMed Central - PubMed

Affiliation: AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411 001, India.

ABSTRACT
The aim of the current study was to design sustained release matrix tablets of venlafaxine hydrochloride using ion exchange resin with the incorporation of hydrophilic and hydrophobic polymer combinations. Venlafaxine HCl was loaded onto Indion 244 by batch method and then resinate were wet granulated with ethyl cellulose and blended with hydroxypropylmethylcellulose and compressed. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profile at 2 h and at 18 h. Hydroxypropylmethylcellulose and ethylcellulose were taken as the independent variables. Response surface plots and contour plots were drawn, and optimum formulations were selected by feasibility and grid searches. Resinate shows inadequate sustained release profile. Compressed matrices exhibited the anomalous release mechanism, as the value of release rate exponent (n) varied between 08109 and 08719, resulting in regulated and complete release until 20 h. Validation of optimization study, performed using five confirmatory runs, indicated very high degree of prognostic ability of response surface methodology, with mean percentage error as 1.152+/-1.88%. Regulated drug release study indicates that the hydrophilic and hydrophobic matrix tablets of venlafaxine resinate prepared using hydroxypropylmethylcellulose and ethylcellulose, can successfully be employed as a once-a-day oral controlled release drug delivery system.

No MeSH data available.