Limits...
Cefoperazone sodium impregnated polycaprolactone composite implant for osteomyelitis.

Anand A, Pundir R, Pandian CS, Saraf S, Gupta H - Indian J Pharm Sci (2009)

Bottom Line: The pellet were also tested for microbiological efficacy and compared with plain drug solution in different concentrations.The release profile displayed drug levels above MIC continuously up to 2 months.Wide zone of inhibition by pellet against Staph. aureus as compared to drug solution proves its efficacy in treatment of osteomyelitis.

View Article: PubMed Central - PubMed

Affiliation: Babu Banarasi Das National Institute of Technology & Management, Lucknow-226 007, India.

ABSTRACT
The use of local antibiotics from a biodegradable implant for chronic osteomyelitis is an attractive alternative. The implant delivers high antibiotic concentration at tissue levels, obliterates dead space, aids bone repair and does not need to be removed. The purpose of this paper is to develop and evaluate a calcium sulphate and polycaprolactone based composite biodegradable implantable delivery system of cefoperazone sodium. Implants were prepared by modified fabrication technique to avoid solvent use. Interaction studies were carried out to check any incompatibility between ingredients. Prepared implants were evaluated for various in vitro parameters like dimensions, hardness, tensile strength, drug release profile and sterility. Morphological changes in pellet before and after drug release were evaluated by scanning electron microscopy. The pellet were also tested for microbiological efficacy and compared with plain drug solution in different concentrations. Developed pellets are regular in shape and size with good tensile strength. The release profile displayed drug levels above MIC continuously up to 2 months. Wide zone of inhibition by pellet against Staph. aureus as compared to drug solution proves its efficacy in treatment of osteomyelitis.

No MeSH data available.


Related in: MedlinePlus

Scanning electron micrographs of cefoperazone sodium pellets.Scanning electron micrographs showing the surface morphology of cefoperazone sodium pellets (a) before and (b) after in vitro release study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2865808&req=5

Figure 0003: Scanning electron micrographs of cefoperazone sodium pellets.Scanning electron micrographs showing the surface morphology of cefoperazone sodium pellets (a) before and (b) after in vitro release study.

Mentions: In general, rods displayed very similar texture and morphology regardless of the polymer and antibiotic type used. Cefoperazone sodium loaded pellets were examined before and after 15 days in the release medium. It was observed that before release, the antibiotic crystals on the surface of the rods were partially exposed (fig. 3a) and surface was smooth as compared to SEM micrograph of pellet after drug release. When the drug-loaded pellets were placed in the aqueous environment, pores were created on the exposed part due to removal of drug particles through dissolution. These pores led to water penetration into the pellet and caused further drug dissolution. (fig. 3b). Voids generated reveals uniform drug distribution and release due to diffusion from pellets.


Cefoperazone sodium impregnated polycaprolactone composite implant for osteomyelitis.

Anand A, Pundir R, Pandian CS, Saraf S, Gupta H - Indian J Pharm Sci (2009)

Scanning electron micrographs of cefoperazone sodium pellets.Scanning electron micrographs showing the surface morphology of cefoperazone sodium pellets (a) before and (b) after in vitro release study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865808&req=5

Figure 0003: Scanning electron micrographs of cefoperazone sodium pellets.Scanning electron micrographs showing the surface morphology of cefoperazone sodium pellets (a) before and (b) after in vitro release study.
Mentions: In general, rods displayed very similar texture and morphology regardless of the polymer and antibiotic type used. Cefoperazone sodium loaded pellets were examined before and after 15 days in the release medium. It was observed that before release, the antibiotic crystals on the surface of the rods were partially exposed (fig. 3a) and surface was smooth as compared to SEM micrograph of pellet after drug release. When the drug-loaded pellets were placed in the aqueous environment, pores were created on the exposed part due to removal of drug particles through dissolution. These pores led to water penetration into the pellet and caused further drug dissolution. (fig. 3b). Voids generated reveals uniform drug distribution and release due to diffusion from pellets.

Bottom Line: The pellet were also tested for microbiological efficacy and compared with plain drug solution in different concentrations.The release profile displayed drug levels above MIC continuously up to 2 months.Wide zone of inhibition by pellet against Staph. aureus as compared to drug solution proves its efficacy in treatment of osteomyelitis.

View Article: PubMed Central - PubMed

Affiliation: Babu Banarasi Das National Institute of Technology & Management, Lucknow-226 007, India.

ABSTRACT
The use of local antibiotics from a biodegradable implant for chronic osteomyelitis is an attractive alternative. The implant delivers high antibiotic concentration at tissue levels, obliterates dead space, aids bone repair and does not need to be removed. The purpose of this paper is to develop and evaluate a calcium sulphate and polycaprolactone based composite biodegradable implantable delivery system of cefoperazone sodium. Implants were prepared by modified fabrication technique to avoid solvent use. Interaction studies were carried out to check any incompatibility between ingredients. Prepared implants were evaluated for various in vitro parameters like dimensions, hardness, tensile strength, drug release profile and sterility. Morphological changes in pellet before and after drug release were evaluated by scanning electron microscopy. The pellet were also tested for microbiological efficacy and compared with plain drug solution in different concentrations. Developed pellets are regular in shape and size with good tensile strength. The release profile displayed drug levels above MIC continuously up to 2 months. Wide zone of inhibition by pellet against Staph. aureus as compared to drug solution proves its efficacy in treatment of osteomyelitis.

No MeSH data available.


Related in: MedlinePlus