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Cefoperazone sodium impregnated polycaprolactone composite implant for osteomyelitis.

Anand A, Pundir R, Pandian CS, Saraf S, Gupta H - Indian J Pharm Sci (2009)

Bottom Line: The pellet were also tested for microbiological efficacy and compared with plain drug solution in different concentrations.The release profile displayed drug levels above MIC continuously up to 2 months.Wide zone of inhibition by pellet against Staph. aureus as compared to drug solution proves its efficacy in treatment of osteomyelitis.

View Article: PubMed Central - PubMed

Affiliation: Babu Banarasi Das National Institute of Technology & Management, Lucknow-226 007, India.

ABSTRACT
The use of local antibiotics from a biodegradable implant for chronic osteomyelitis is an attractive alternative. The implant delivers high antibiotic concentration at tissue levels, obliterates dead space, aids bone repair and does not need to be removed. The purpose of this paper is to develop and evaluate a calcium sulphate and polycaprolactone based composite biodegradable implantable delivery system of cefoperazone sodium. Implants were prepared by modified fabrication technique to avoid solvent use. Interaction studies were carried out to check any incompatibility between ingredients. Prepared implants were evaluated for various in vitro parameters like dimensions, hardness, tensile strength, drug release profile and sterility. Morphological changes in pellet before and after drug release were evaluated by scanning electron microscopy. The pellet were also tested for microbiological efficacy and compared with plain drug solution in different concentrations. Developed pellets are regular in shape and size with good tensile strength. The release profile displayed drug levels above MIC continuously up to 2 months. Wide zone of inhibition by pellet against Staph. aureus as compared to drug solution proves its efficacy in treatment of osteomyelitis.

No MeSH data available.


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Cefoperazone sodium impregnated calcium sulphatepolycaprolactone composite pellets
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Figure 0001: Cefoperazone sodium impregnated calcium sulphatepolycaprolactone composite pellets

Mentions: Pellets were prepared by a modified fabrication technique. Polycaprolactone polymer, calcium sulphate hemihydrate and cefoperazone sodium was taken in ratio of 1:1:0.75 w/w. Polycaprolactone was first melted and a blend of drug and calcium sulphate hemihydrate were mixed in the molten polymer. The mixture was stirred by a mechanical stirrer for 1 h to ensure proper mixing of the drug with polymer matrix. The composite mixture thus formed was kept for drying. The compact mass was then passed through a sieve No. 16 to form granules. These granules were compressed as pellets in a tablet punching machine, (d-tooling 6 mm, Mini Press, Karnavati, India), fig. 1. The compressed pellets were collected, wrapped in aluminum foils and stored in refrigerator in dry condition till further use. All pellets were sterilized by ethylene oxide sterilization.


Cefoperazone sodium impregnated polycaprolactone composite implant for osteomyelitis.

Anand A, Pundir R, Pandian CS, Saraf S, Gupta H - Indian J Pharm Sci (2009)

Cefoperazone sodium impregnated calcium sulphatepolycaprolactone composite pellets
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865808&req=5

Figure 0001: Cefoperazone sodium impregnated calcium sulphatepolycaprolactone composite pellets
Mentions: Pellets were prepared by a modified fabrication technique. Polycaprolactone polymer, calcium sulphate hemihydrate and cefoperazone sodium was taken in ratio of 1:1:0.75 w/w. Polycaprolactone was first melted and a blend of drug and calcium sulphate hemihydrate were mixed in the molten polymer. The mixture was stirred by a mechanical stirrer for 1 h to ensure proper mixing of the drug with polymer matrix. The composite mixture thus formed was kept for drying. The compact mass was then passed through a sieve No. 16 to form granules. These granules were compressed as pellets in a tablet punching machine, (d-tooling 6 mm, Mini Press, Karnavati, India), fig. 1. The compressed pellets were collected, wrapped in aluminum foils and stored in refrigerator in dry condition till further use. All pellets were sterilized by ethylene oxide sterilization.

Bottom Line: The pellet were also tested for microbiological efficacy and compared with plain drug solution in different concentrations.The release profile displayed drug levels above MIC continuously up to 2 months.Wide zone of inhibition by pellet against Staph. aureus as compared to drug solution proves its efficacy in treatment of osteomyelitis.

View Article: PubMed Central - PubMed

Affiliation: Babu Banarasi Das National Institute of Technology & Management, Lucknow-226 007, India.

ABSTRACT
The use of local antibiotics from a biodegradable implant for chronic osteomyelitis is an attractive alternative. The implant delivers high antibiotic concentration at tissue levels, obliterates dead space, aids bone repair and does not need to be removed. The purpose of this paper is to develop and evaluate a calcium sulphate and polycaprolactone based composite biodegradable implantable delivery system of cefoperazone sodium. Implants were prepared by modified fabrication technique to avoid solvent use. Interaction studies were carried out to check any incompatibility between ingredients. Prepared implants were evaluated for various in vitro parameters like dimensions, hardness, tensile strength, drug release profile and sterility. Morphological changes in pellet before and after drug release were evaluated by scanning electron microscopy. The pellet were also tested for microbiological efficacy and compared with plain drug solution in different concentrations. Developed pellets are regular in shape and size with good tensile strength. The release profile displayed drug levels above MIC continuously up to 2 months. Wide zone of inhibition by pellet against Staph. aureus as compared to drug solution proves its efficacy in treatment of osteomyelitis.

No MeSH data available.


Related in: MedlinePlus