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Antimicrobial evaluation of mangiferin analogues.

Singh SK, Kumar Y, Kumar SS, Sharma VK, Dua K, Samad A - Indian J Pharm Sci (2009)

Bottom Line: Mangiferin was further converted to 5-(N-phenylaminomethyleno)mangiferin, 5-(N-p-chlorophenylaminomethyleno) mangiferin, 5-(N-2-methylphenylaminomethyleno) mangiferin, 5-(N-p-methoxyphenylaminomethyleno) mangiferin, 5-(N, N-diphenylaminomethyleno) mangiferin, 5-(N--napthylaminomethyleno) mangiferin and 5-(N-4-methylphenylaminomethyleno) mangiferin.Mangiferin and its analogues were characterized by melting point and R(f) value determination and through spectral technique like UV, IR, and NMR spectral analysis.The synthesized compounds were screened for antimicrobial activity.

View Article: PubMed Central - PubMed

Affiliation: D. J. College of Pharmacy, Niwari road, Modinagar-201 201, India.

ABSTRACT
The naturally occurring xanthone glycoside mangiferin has been isolated by column chromatography from the ethanol extract of stem bark of Mangifera indica. Mangiferin was further converted to 5-(N-phenylaminomethyleno)mangiferin, 5-(N-p-chlorophenylaminomethyleno) mangiferin, 5-(N-2-methylphenylaminomethyleno) mangiferin, 5-(N-p-methoxyphenylaminomethyleno) mangiferin, 5-(N, N-diphenylaminomethyleno) mangiferin, 5-(N--napthylaminomethyleno) mangiferin and 5-(N-4-methylphenylaminomethyleno) mangiferin. Mangiferin and its analogues were characterized by melting point and R(f) value determination and through spectral technique like UV, IR, and NMR spectral analysis. The synthesized compounds were screened for antimicrobial activity.

No MeSH data available.


Synthesis of mangiferin analogues, 1 is mangiferin
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Figure 0001: Synthesis of mangiferin analogues, 1 is mangiferin

Mentions: The general method used for the preparation of mangiferin analogues is as follows; a mixture of equal mols of mangiferin, powdered paraformaldehyde and aromatic amine, 10 ml of 95% ethanol and 1 ml of concentrated hydrochloric acid was refluxed, cooled to room temperature and kept in a refrigerator overnight. The solid was filtered and washed with water and recrystallized from ethanol (Scheme 1).


Antimicrobial evaluation of mangiferin analogues.

Singh SK, Kumar Y, Kumar SS, Sharma VK, Dua K, Samad A - Indian J Pharm Sci (2009)

Synthesis of mangiferin analogues, 1 is mangiferin
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865799&req=5

Figure 0001: Synthesis of mangiferin analogues, 1 is mangiferin
Mentions: The general method used for the preparation of mangiferin analogues is as follows; a mixture of equal mols of mangiferin, powdered paraformaldehyde and aromatic amine, 10 ml of 95% ethanol and 1 ml of concentrated hydrochloric acid was refluxed, cooled to room temperature and kept in a refrigerator overnight. The solid was filtered and washed with water and recrystallized from ethanol (Scheme 1).

Bottom Line: Mangiferin was further converted to 5-(N-phenylaminomethyleno)mangiferin, 5-(N-p-chlorophenylaminomethyleno) mangiferin, 5-(N-2-methylphenylaminomethyleno) mangiferin, 5-(N-p-methoxyphenylaminomethyleno) mangiferin, 5-(N, N-diphenylaminomethyleno) mangiferin, 5-(N--napthylaminomethyleno) mangiferin and 5-(N-4-methylphenylaminomethyleno) mangiferin.Mangiferin and its analogues were characterized by melting point and R(f) value determination and through spectral technique like UV, IR, and NMR spectral analysis.The synthesized compounds were screened for antimicrobial activity.

View Article: PubMed Central - PubMed

Affiliation: D. J. College of Pharmacy, Niwari road, Modinagar-201 201, India.

ABSTRACT
The naturally occurring xanthone glycoside mangiferin has been isolated by column chromatography from the ethanol extract of stem bark of Mangifera indica. Mangiferin was further converted to 5-(N-phenylaminomethyleno)mangiferin, 5-(N-p-chlorophenylaminomethyleno) mangiferin, 5-(N-2-methylphenylaminomethyleno) mangiferin, 5-(N-p-methoxyphenylaminomethyleno) mangiferin, 5-(N, N-diphenylaminomethyleno) mangiferin, 5-(N--napthylaminomethyleno) mangiferin and 5-(N-4-methylphenylaminomethyleno) mangiferin. Mangiferin and its analogues were characterized by melting point and R(f) value determination and through spectral technique like UV, IR, and NMR spectral analysis. The synthesized compounds were screened for antimicrobial activity.

No MeSH data available.