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Investigation of Hydrogel Isolated from Seeds of Ocimum basilicum as Binder.

Bhosale AV, Hardikar S, Pathak AA, Sable RV - Indian J Pharm Sci (2009)

Bottom Line: The compressibility is the ability of the powder to deform under pressure and the compactibility is the ability of a powder to form coherent compacts.To test the functionality of novel excipients, Sonnergaard proved a simple linear model to confirm compactability, which is an uncomplicated tool for quantification.The tablets were compressed at increasing compression pressures and were evaluated for various mechanical properties.

View Article: PubMed Central - PubMed

Affiliation: Poona District Education Association's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412 301, India.

ABSTRACT
Ayurvedic powders are widely used as therapeutic agents but most of them have unpleasant taste and large doses. One of the possible approach to overcome these drawbacks is to represent them in unit dosage form i.e. tablet dosage form. The purpose of this study is to elucidate and quantify the compressibility and compactibility of herbal granules prepared by using hydrogel isolated from whole seeds of Ocimum basilicum as a novel binder. The compressibility is the ability of the powder to deform under pressure and the compactibility is the ability of a powder to form coherent compacts. To test the functionality of novel excipients, Sonnergaard proved a simple linear model to confirm compactability, which is an uncomplicated tool for quantification. The tablets were compressed at increasing compression pressures and were evaluated for various mechanical properties. The linear relationship between specific crushing strength and compression pressure revealed the compactibility of the herbal granules and the linear relationship between porosity and logarithm of compression pressure revealed the compressible nature of the herbal granules according to the model developed by Sonnergaard. Thus the hydrogel isolated from whole seeds of Ocimum basillicum had potential as a granulating and binding agent.

No MeSH data available.


Related in: MedlinePlus

Linear relationship between specific crushing strength of tablets and compression pressure.Compactibility of granules was confirmed by linear relationship between specific crushing strength of tablets and compression pressure. The equation obtained was y = 3.001x-0.133 with r2 value of 0.9936.
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Figure 0003: Linear relationship between specific crushing strength of tablets and compression pressure.Compactibility of granules was confirmed by linear relationship between specific crushing strength of tablets and compression pressure. The equation obtained was y = 3.001x-0.133 with r2 value of 0.9936.

Mentions: In fig. 2, porosity of a tablet was plotted against logarithm of compression pressure. A linear relationship was observed. This indicated the compressible nature of granules. The compactibility is more relevant and interesting from practical point of view. With the growing interest in the functionality of excipients there was a need for simple and standardised measure of compactibility. Sonnergaard[9] established a simple linear model for compactibility. He calculated specific crushing strength (SCS) and showed that the slope of the regression line SCP= Cp*P+b represents dimensionless compactibility parameter[9–10]. In fig. 3 specific crushing strength was plotted against compression pressure. A straight line was obtained which revealed the compactibility of granules. Since above relations are linear, the Triphala granules had optimum compressibility and compactibility when prepared by using hydrogel obtained from whole seeds of Ocimum basilicum as a novel binding and granulating agent.


Investigation of Hydrogel Isolated from Seeds of Ocimum basilicum as Binder.

Bhosale AV, Hardikar S, Pathak AA, Sable RV - Indian J Pharm Sci (2009)

Linear relationship between specific crushing strength of tablets and compression pressure.Compactibility of granules was confirmed by linear relationship between specific crushing strength of tablets and compression pressure. The equation obtained was y = 3.001x-0.133 with r2 value of 0.9936.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865796&req=5

Figure 0003: Linear relationship between specific crushing strength of tablets and compression pressure.Compactibility of granules was confirmed by linear relationship between specific crushing strength of tablets and compression pressure. The equation obtained was y = 3.001x-0.133 with r2 value of 0.9936.
Mentions: In fig. 2, porosity of a tablet was plotted against logarithm of compression pressure. A linear relationship was observed. This indicated the compressible nature of granules. The compactibility is more relevant and interesting from practical point of view. With the growing interest in the functionality of excipients there was a need for simple and standardised measure of compactibility. Sonnergaard[9] established a simple linear model for compactibility. He calculated specific crushing strength (SCS) and showed that the slope of the regression line SCP= Cp*P+b represents dimensionless compactibility parameter[9–10]. In fig. 3 specific crushing strength was plotted against compression pressure. A straight line was obtained which revealed the compactibility of granules. Since above relations are linear, the Triphala granules had optimum compressibility and compactibility when prepared by using hydrogel obtained from whole seeds of Ocimum basilicum as a novel binding and granulating agent.

Bottom Line: The compressibility is the ability of the powder to deform under pressure and the compactibility is the ability of a powder to form coherent compacts.To test the functionality of novel excipients, Sonnergaard proved a simple linear model to confirm compactability, which is an uncomplicated tool for quantification.The tablets were compressed at increasing compression pressures and were evaluated for various mechanical properties.

View Article: PubMed Central - PubMed

Affiliation: Poona District Education Association's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412 301, India.

ABSTRACT
Ayurvedic powders are widely used as therapeutic agents but most of them have unpleasant taste and large doses. One of the possible approach to overcome these drawbacks is to represent them in unit dosage form i.e. tablet dosage form. The purpose of this study is to elucidate and quantify the compressibility and compactibility of herbal granules prepared by using hydrogel isolated from whole seeds of Ocimum basilicum as a novel binder. The compressibility is the ability of the powder to deform under pressure and the compactibility is the ability of a powder to form coherent compacts. To test the functionality of novel excipients, Sonnergaard proved a simple linear model to confirm compactability, which is an uncomplicated tool for quantification. The tablets were compressed at increasing compression pressures and were evaluated for various mechanical properties. The linear relationship between specific crushing strength and compression pressure revealed the compactibility of the herbal granules and the linear relationship between porosity and logarithm of compression pressure revealed the compressible nature of the herbal granules according to the model developed by Sonnergaard. Thus the hydrogel isolated from whole seeds of Ocimum basillicum had potential as a granulating and binding agent.

No MeSH data available.


Related in: MedlinePlus