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Investigation of Hydrogel Isolated from Seeds of Ocimum basilicum as Binder.

Bhosale AV, Hardikar S, Pathak AA, Sable RV - Indian J Pharm Sci (2009)

Bottom Line: The compressibility is the ability of the powder to deform under pressure and the compactibility is the ability of a powder to form coherent compacts.To test the functionality of novel excipients, Sonnergaard proved a simple linear model to confirm compactability, which is an uncomplicated tool for quantification.The tablets were compressed at increasing compression pressures and were evaluated for various mechanical properties.

View Article: PubMed Central - PubMed

Affiliation: Poona District Education Association's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412 301, India.

ABSTRACT
Ayurvedic powders are widely used as therapeutic agents but most of them have unpleasant taste and large doses. One of the possible approach to overcome these drawbacks is to represent them in unit dosage form i.e. tablet dosage form. The purpose of this study is to elucidate and quantify the compressibility and compactibility of herbal granules prepared by using hydrogel isolated from whole seeds of Ocimum basilicum as a novel binder. The compressibility is the ability of the powder to deform under pressure and the compactibility is the ability of a powder to form coherent compacts. To test the functionality of novel excipients, Sonnergaard proved a simple linear model to confirm compactability, which is an uncomplicated tool for quantification. The tablets were compressed at increasing compression pressures and were evaluated for various mechanical properties. The linear relationship between specific crushing strength and compression pressure revealed the compactibility of the herbal granules and the linear relationship between porosity and logarithm of compression pressure revealed the compressible nature of the herbal granules according to the model developed by Sonnergaard. Thus the hydrogel isolated from whole seeds of Ocimum basillicum had potential as a granulating and binding agent.

No MeSH data available.


Related in: MedlinePlus

Calibration curve for hydrogel in the range 2 to 16 ppm. The equation of the line obtained was y= 0.0249x+0.0288 with r2 value of 0.9951.
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Figure 0001: Calibration curve for hydrogel in the range 2 to 16 ppm. The equation of the line obtained was y= 0.0249x+0.0288 with r2 value of 0.9951.

Mentions: Hydrogel was characterised for appearance, specific gravity and viscosity. Hydrogel was white, translucent and viscous liquid with specific gravity 1.013[5]. Viscosity of hydrogel was measured by using Brookfield viscometer (Model- DV II +) with spindle number 61. Viscosity of liquid decreased with increasing rate of shear. Thus hydrogel was shear thinning system. The results are reported in Table 1. It was also scanned for UV absorption. It absorbs UV radiation at 296 nm. This can be used as identification and quantification test of hydrogel as it obeys Beers Lamberts Law in the range 2 ppm to 16 ppm (fig. 1). About 25 g of seeds yielded 1.1 l of hydrogel of specifications reported in Table 1.


Investigation of Hydrogel Isolated from Seeds of Ocimum basilicum as Binder.

Bhosale AV, Hardikar S, Pathak AA, Sable RV - Indian J Pharm Sci (2009)

Calibration curve for hydrogel in the range 2 to 16 ppm. The equation of the line obtained was y= 0.0249x+0.0288 with r2 value of 0.9951.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865796&req=5

Figure 0001: Calibration curve for hydrogel in the range 2 to 16 ppm. The equation of the line obtained was y= 0.0249x+0.0288 with r2 value of 0.9951.
Mentions: Hydrogel was characterised for appearance, specific gravity and viscosity. Hydrogel was white, translucent and viscous liquid with specific gravity 1.013[5]. Viscosity of hydrogel was measured by using Brookfield viscometer (Model- DV II +) with spindle number 61. Viscosity of liquid decreased with increasing rate of shear. Thus hydrogel was shear thinning system. The results are reported in Table 1. It was also scanned for UV absorption. It absorbs UV radiation at 296 nm. This can be used as identification and quantification test of hydrogel as it obeys Beers Lamberts Law in the range 2 ppm to 16 ppm (fig. 1). About 25 g of seeds yielded 1.1 l of hydrogel of specifications reported in Table 1.

Bottom Line: The compressibility is the ability of the powder to deform under pressure and the compactibility is the ability of a powder to form coherent compacts.To test the functionality of novel excipients, Sonnergaard proved a simple linear model to confirm compactability, which is an uncomplicated tool for quantification.The tablets were compressed at increasing compression pressures and were evaluated for various mechanical properties.

View Article: PubMed Central - PubMed

Affiliation: Poona District Education Association's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412 301, India.

ABSTRACT
Ayurvedic powders are widely used as therapeutic agents but most of them have unpleasant taste and large doses. One of the possible approach to overcome these drawbacks is to represent them in unit dosage form i.e. tablet dosage form. The purpose of this study is to elucidate and quantify the compressibility and compactibility of herbal granules prepared by using hydrogel isolated from whole seeds of Ocimum basilicum as a novel binder. The compressibility is the ability of the powder to deform under pressure and the compactibility is the ability of a powder to form coherent compacts. To test the functionality of novel excipients, Sonnergaard proved a simple linear model to confirm compactability, which is an uncomplicated tool for quantification. The tablets were compressed at increasing compression pressures and were evaluated for various mechanical properties. The linear relationship between specific crushing strength and compression pressure revealed the compactibility of the herbal granules and the linear relationship between porosity and logarithm of compression pressure revealed the compressible nature of the herbal granules according to the model developed by Sonnergaard. Thus the hydrogel isolated from whole seeds of Ocimum basillicum had potential as a granulating and binding agent.

No MeSH data available.


Related in: MedlinePlus