Limits...
Characterization of gelatin-sodium alginate complex coacervation system.

Shinde UA, Nagarsenker MS - Indian J Pharm Sci (2009)

Bottom Line: A gelatin and sodium alginate complex coacervation system was studied and an effect of pH and colloid mixing ratios on coacervation was investigated.A colloid mixing ratio at which optimum coacervation occurred varied with the coacervation pH.Optimum coacervation occurred at pH 3.5 at a gelatin sodium alginate ratio 4:1.

View Article: PubMed Central - PubMed

Affiliation: Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai-400 098, India.

ABSTRACT
A gelatin and sodium alginate complex coacervation system was studied and an effect of pH and colloid mixing ratios on coacervation was investigated. A colloid mixing ratio at which optimum coacervation occurred varied with the coacervation pH. Viscometric, turbidity and coacervate dry yield investigations were used to investigate optimum conditions for complex coacervation. Optimum coacervation occurred at pH 3.5 at a gelatin sodium alginate ratio 4:1. Coacervate and equilibrium fluid was analyzed for gelatin and sodium alginate contents and yields calculated on the basis of chemical analysis showed that optimum coacervation occurred at 25% sodium alginate fraction at pH 3.5.

No MeSH data available.


Effect of % sodium alginate content in colloid mixture on percent coacervate dry yield.pH 2.5 (–◆–), pH 3.0 (–□–), pH 3.5 (–Ж–), pH 4.0 (–●–).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2865794&req=5

Figure 0003: Effect of % sodium alginate content in colloid mixture on percent coacervate dry yield.pH 2.5 (–◆–), pH 3.0 (–□–), pH 3.5 (–Ж–), pH 4.0 (–●–).

Mentions: The effect of colloid ratio on coacervate dry yield is shown in fig. 3. It was clearly evident that as the percentage of sodium alginate in coacervate mixture was increased, yield also increased till it reached to optimum value after which it decreased. At higher fraction of sodium alginate, colloid solution became very viscous which lead to poor separation of coacervate and hence decreased yield. It was noted that increase in the pH resulted in a shift of optimal mixing ratio towards a lower sodium alginate fraction i.e. peak yield occurred at 50% sodium alginate at pH 2.5 but at pH 4 peak yield was obtained at 20% sodium alginate concentration. Thus, for each colloid ratio the maximum coacervate yield was obtained at one pH value which was optimum for particular ratio. The maximum yield occurred at 20% sodium alginate concentration at pH 3.5.


Characterization of gelatin-sodium alginate complex coacervation system.

Shinde UA, Nagarsenker MS - Indian J Pharm Sci (2009)

Effect of % sodium alginate content in colloid mixture on percent coacervate dry yield.pH 2.5 (–◆–), pH 3.0 (–□–), pH 3.5 (–Ж–), pH 4.0 (–●–).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865794&req=5

Figure 0003: Effect of % sodium alginate content in colloid mixture on percent coacervate dry yield.pH 2.5 (–◆–), pH 3.0 (–□–), pH 3.5 (–Ж–), pH 4.0 (–●–).
Mentions: The effect of colloid ratio on coacervate dry yield is shown in fig. 3. It was clearly evident that as the percentage of sodium alginate in coacervate mixture was increased, yield also increased till it reached to optimum value after which it decreased. At higher fraction of sodium alginate, colloid solution became very viscous which lead to poor separation of coacervate and hence decreased yield. It was noted that increase in the pH resulted in a shift of optimal mixing ratio towards a lower sodium alginate fraction i.e. peak yield occurred at 50% sodium alginate at pH 2.5 but at pH 4 peak yield was obtained at 20% sodium alginate concentration. Thus, for each colloid ratio the maximum coacervate yield was obtained at one pH value which was optimum for particular ratio. The maximum yield occurred at 20% sodium alginate concentration at pH 3.5.

Bottom Line: A gelatin and sodium alginate complex coacervation system was studied and an effect of pH and colloid mixing ratios on coacervation was investigated.A colloid mixing ratio at which optimum coacervation occurred varied with the coacervation pH.Optimum coacervation occurred at pH 3.5 at a gelatin sodium alginate ratio 4:1.

View Article: PubMed Central - PubMed

Affiliation: Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai-400 098, India.

ABSTRACT
A gelatin and sodium alginate complex coacervation system was studied and an effect of pH and colloid mixing ratios on coacervation was investigated. A colloid mixing ratio at which optimum coacervation occurred varied with the coacervation pH. Viscometric, turbidity and coacervate dry yield investigations were used to investigate optimum conditions for complex coacervation. Optimum coacervation occurred at pH 3.5 at a gelatin sodium alginate ratio 4:1. Coacervate and equilibrium fluid was analyzed for gelatin and sodium alginate contents and yields calculated on the basis of chemical analysis showed that optimum coacervation occurred at 25% sodium alginate fraction at pH 3.5.

No MeSH data available.