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Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tablets.

Keny RV, Mankame SA, Lourenco CF - Indian J Pharm Sci (2009)

Bottom Line: The formulated tablets were also compared with a marketed product.The results of the dissolution study indicate that formulations FC-IV, FC-V and FC-VI showed maximum drug release upto 24 h, whereas the marketed product was found to extend the release only up to 14 h.Incase of formulations containing combination of hydroxypropylmethylcellulose and ethyl cellulose (FC-I to FC-IX), the release of the drug was found to be dependent on the relative proportions of hydroxypropylmethylcellulose and ethyl cellulose used in the tablet matrix.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Goa College of Pharmacy, Panaji, Goa-403 001, India.

ABSTRACT
The present study was aimed to develop once daily extended release matrix tablets of minocycline hydrochloride, using hydroxypropylmethylcellulose either alone or in combination with ethyl cellulose as the matrix material in different proportions. The formulated tablets were also compared with a marketed product. The results of the dissolution study indicate that formulations FC-IV, FC-V and FC-VI showed maximum drug release upto 24 h, whereas the marketed product was found to extend the release only up to 14 h. Incase of formulations containing combination of hydroxypropylmethylcellulose and ethyl cellulose (FC-I to FC-IX), the release of the drug was found to be dependent on the relative proportions of hydroxypropylmethylcellulose and ethyl cellulose used in the tablet matrix. Mathematical treatment of the in vitro drug release data suggests that, all the formulations best fitted into first order release kinetics. Drug release from the matrix occurred by combination of two mechanisms, diffusion of drug from tablet matrix and erosion of tablet surface, which was reflected from Higuchi's model and Erosion plot.

No MeSH data available.


Related in: MedlinePlus

The in vitro release profiles of minocycline from F-IV, F-V and F-VI.Release profiles of minocycline from formulations containing varying HPMC K15M content; F-IV [HPMC K15M, 20%] (-♦-), F-V [HPMC K15M, 30%] (-◊-) and F-VI [HPMC K15M, 40%] (-▲-). Each data point represents mean±SD (n = 6).
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Figure 0002: The in vitro release profiles of minocycline from F-IV, F-V and F-VI.Release profiles of minocycline from formulations containing varying HPMC K15M content; F-IV [HPMC K15M, 20%] (-♦-), F-V [HPMC K15M, 30%] (-◊-) and F-VI [HPMC K15M, 40%] (-▲-). Each data point represents mean±SD (n = 6).

Mentions: Fig. 1 shows the effect of different concentrations of HPMC K4M 20% (F-I), 30% (F-II) and 40% wt/wt of tablet (F-III) on % release (99.34, 97.71 and 95.03% within 11 h of dissolution study, respectively) of minocycline HCl. No significant difference in release rate was observed between tablets containing either 20 or 30 or 40% of HPMC K4M. However, 40-50% of drug was released in first 2 h of dissolution. Similarly Fig. 2 shows the effect of different concentrations of HPMC K15M 20% (F-IV), 30% (F-V) and 40% wt/wt of tablet (F-VI) on % release (101.36, 100.36 and 98.15 within 14 h of dissolution study, respectively) of the drug. However 40-50% of drug was released in the first 2 h of dissolution study. The % release of formulations with HPMC K15M (F-IV to F-VI) was found to be extended than that of formulations with HPMC K4M (F-I to F-III) due to the use of a more viscous grade of HPMC.


Formulation and evaluation of once daily minocycline hydrochloride extended release matrix tablets.

Keny RV, Mankame SA, Lourenco CF - Indian J Pharm Sci (2009)

The in vitro release profiles of minocycline from F-IV, F-V and F-VI.Release profiles of minocycline from formulations containing varying HPMC K15M content; F-IV [HPMC K15M, 20%] (-♦-), F-V [HPMC K15M, 30%] (-◊-) and F-VI [HPMC K15M, 40%] (-▲-). Each data point represents mean±SD (n = 6).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865789&req=5

Figure 0002: The in vitro release profiles of minocycline from F-IV, F-V and F-VI.Release profiles of minocycline from formulations containing varying HPMC K15M content; F-IV [HPMC K15M, 20%] (-♦-), F-V [HPMC K15M, 30%] (-◊-) and F-VI [HPMC K15M, 40%] (-▲-). Each data point represents mean±SD (n = 6).
Mentions: Fig. 1 shows the effect of different concentrations of HPMC K4M 20% (F-I), 30% (F-II) and 40% wt/wt of tablet (F-III) on % release (99.34, 97.71 and 95.03% within 11 h of dissolution study, respectively) of minocycline HCl. No significant difference in release rate was observed between tablets containing either 20 or 30 or 40% of HPMC K4M. However, 40-50% of drug was released in first 2 h of dissolution. Similarly Fig. 2 shows the effect of different concentrations of HPMC K15M 20% (F-IV), 30% (F-V) and 40% wt/wt of tablet (F-VI) on % release (101.36, 100.36 and 98.15 within 14 h of dissolution study, respectively) of the drug. However 40-50% of drug was released in the first 2 h of dissolution study. The % release of formulations with HPMC K15M (F-IV to F-VI) was found to be extended than that of formulations with HPMC K4M (F-I to F-III) due to the use of a more viscous grade of HPMC.

Bottom Line: The formulated tablets were also compared with a marketed product.The results of the dissolution study indicate that formulations FC-IV, FC-V and FC-VI showed maximum drug release upto 24 h, whereas the marketed product was found to extend the release only up to 14 h.Incase of formulations containing combination of hydroxypropylmethylcellulose and ethyl cellulose (FC-I to FC-IX), the release of the drug was found to be dependent on the relative proportions of hydroxypropylmethylcellulose and ethyl cellulose used in the tablet matrix.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Goa College of Pharmacy, Panaji, Goa-403 001, India.

ABSTRACT
The present study was aimed to develop once daily extended release matrix tablets of minocycline hydrochloride, using hydroxypropylmethylcellulose either alone or in combination with ethyl cellulose as the matrix material in different proportions. The formulated tablets were also compared with a marketed product. The results of the dissolution study indicate that formulations FC-IV, FC-V and FC-VI showed maximum drug release upto 24 h, whereas the marketed product was found to extend the release only up to 14 h. Incase of formulations containing combination of hydroxypropylmethylcellulose and ethyl cellulose (FC-I to FC-IX), the release of the drug was found to be dependent on the relative proportions of hydroxypropylmethylcellulose and ethyl cellulose used in the tablet matrix. Mathematical treatment of the in vitro drug release data suggests that, all the formulations best fitted into first order release kinetics. Drug release from the matrix occurred by combination of two mechanisms, diffusion of drug from tablet matrix and erosion of tablet surface, which was reflected from Higuchi's model and Erosion plot.

No MeSH data available.


Related in: MedlinePlus