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Preparation and evaluation of microencapsulated fast melt tablets of ambroxol hydrochloride.

Jacob S, Shirwaikar A - Indian J Pharm Sci (2009)

Bottom Line: Natural resources in general and plant materials in particular are receiving more attention due to their safety as pharmaceutical excipients.The resulting granules were found to melt fast at body temperature, have smooth mouth feel and good physical stability.This study demonstrated that pectin could be a right choice in developing patient favored formulations for bitter drugs and can be utilized in fast disintegrating dosage forms as well.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Sciences, S. Bhagwan Singh (PG) Institute of Biomedical Sciences and Research, Balawala, Dehradun-248 161, India.

ABSTRACT
Natural resources in general and plant materials in particular are receiving more attention due to their safety as pharmaceutical excipients. Present work assessed the potential of a natural polysaccharide, pectin to mask the bitter taste of ambroxol hydrochloride, by microencapsulation technique, and its possibility to formulate as a fast disintegrating dosage form. Taste masking is an important developmental challenge in fast dissolving drug delivery system since it dissolves or disintegrates in the patient's mouth in close proximity to the taste buds. The prepared microspheres by emulsion solvent evaporation technique possessed good sphericity, smooth surface morphology, uniform and narrow size distribution (10-90 mum), when analyzed by scanning electron microscopy, laser diffraction and optical microscopy. Method of preparation has influenced the particle size and drug loading efficiency. Drug-polymer compatibility was confirmed by Fourier transform infrared spectroscopy and thin layer chromatography. DSC and X-ray diffraction studies revealed that the drug was dispersed inside the microspheres in the form of an insoluble matrix. The formation of microspheres was affected by glass transition temperature of the polymer, surfactant, type of plasticizers, volume of internal phase, stirrer speed etc. Fast dissolving tablets were prepared by the modification of melt granulation technique. The resulting granules were found to melt fast at body temperature, have smooth mouth feel and good physical stability. This study demonstrated that pectin could be a right choice in developing patient favored formulations for bitter drugs and can be utilized in fast disintegrating dosage forms as well.

No MeSH data available.


Related in: MedlinePlus

Scanning electron micrograph of microspheres.Scanning electron micrograph of a single and group of pectin microspheres, drug:pectin ratio is 1:7.
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Figure 0001: Scanning electron micrograph of microspheres.Scanning electron micrograph of a single and group of pectin microspheres, drug:pectin ratio is 1:7.

Mentions: SEM photographs were taken for the pectin microspheres prepared by emulsion solvent evaporation technique and are depicted in fig. 1. The sample was mounted on an aluminum stud using double adhesive carbon tape. Microspheres were coated using Poloron E5100 SEM, coating system. Scanning was done using LEO Electron microscopy Ltd, Cambridge; UK. The micrographs were recorded at HT 15 KV accelerating voltage using LEO 435VP.


Preparation and evaluation of microencapsulated fast melt tablets of ambroxol hydrochloride.

Jacob S, Shirwaikar A - Indian J Pharm Sci (2009)

Scanning electron micrograph of microspheres.Scanning electron micrograph of a single and group of pectin microspheres, drug:pectin ratio is 1:7.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2865786&req=5

Figure 0001: Scanning electron micrograph of microspheres.Scanning electron micrograph of a single and group of pectin microspheres, drug:pectin ratio is 1:7.
Mentions: SEM photographs were taken for the pectin microspheres prepared by emulsion solvent evaporation technique and are depicted in fig. 1. The sample was mounted on an aluminum stud using double adhesive carbon tape. Microspheres were coated using Poloron E5100 SEM, coating system. Scanning was done using LEO Electron microscopy Ltd, Cambridge; UK. The micrographs were recorded at HT 15 KV accelerating voltage using LEO 435VP.

Bottom Line: Natural resources in general and plant materials in particular are receiving more attention due to their safety as pharmaceutical excipients.The resulting granules were found to melt fast at body temperature, have smooth mouth feel and good physical stability.This study demonstrated that pectin could be a right choice in developing patient favored formulations for bitter drugs and can be utilized in fast disintegrating dosage forms as well.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Sciences, S. Bhagwan Singh (PG) Institute of Biomedical Sciences and Research, Balawala, Dehradun-248 161, India.

ABSTRACT
Natural resources in general and plant materials in particular are receiving more attention due to their safety as pharmaceutical excipients. Present work assessed the potential of a natural polysaccharide, pectin to mask the bitter taste of ambroxol hydrochloride, by microencapsulation technique, and its possibility to formulate as a fast disintegrating dosage form. Taste masking is an important developmental challenge in fast dissolving drug delivery system since it dissolves or disintegrates in the patient's mouth in close proximity to the taste buds. The prepared microspheres by emulsion solvent evaporation technique possessed good sphericity, smooth surface morphology, uniform and narrow size distribution (10-90 mum), when analyzed by scanning electron microscopy, laser diffraction and optical microscopy. Method of preparation has influenced the particle size and drug loading efficiency. Drug-polymer compatibility was confirmed by Fourier transform infrared spectroscopy and thin layer chromatography. DSC and X-ray diffraction studies revealed that the drug was dispersed inside the microspheres in the form of an insoluble matrix. The formation of microspheres was affected by glass transition temperature of the polymer, surfactant, type of plasticizers, volume of internal phase, stirrer speed etc. Fast dissolving tablets were prepared by the modification of melt granulation technique. The resulting granules were found to melt fast at body temperature, have smooth mouth feel and good physical stability. This study demonstrated that pectin could be a right choice in developing patient favored formulations for bitter drugs and can be utilized in fast disintegrating dosage forms as well.

No MeSH data available.


Related in: MedlinePlus