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Retinal nerve fibre layer thickness analysis in X-linked retinoschisis using Fourier-domain OCT.

Genead MA, Pasadhika S, Fishman GA - Eye (Lond) (2009)

Bottom Line: A quadrant of the RNFL was considered to be thinned if at least two of the four segments in the quadrant were reduced in thickness.Thinning in the inferior quadrant was most commonly seen and was observed in 12 patients (50%), followed by the temporal quadrant in 8 patients (33.3%), nasal quadrant in 4 patients (16.7%), and the superior quadrant in 4 patients (16.7%).Among our 24 patients with XLRS, 15 patients (62.5%) showed a thinning of the RNFL in one or more quadrants in at least one eye and 9 patients (37.5%) in both eyes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

ABSTRACT

Purpose: To evaluate the presence of retinal nerve fibre layer (RNFL) defects in patients with X-linked retinoschisis (XLRS) using high-speed, high-resolution, Fourier domain OCT (FD-OCT).

Methods: Twenty-four patients with XLRS seen by the authors were enrolled in the study. All patients underwent a complete eye examination. FD-OCT was performed using Optovue technology. A quadrant of the RNFL was considered to be thinned if at least two of the four segments in the quadrant were reduced in thickness.

Results: The average age of the 24 patients in the study was 28.8+/-14.7 years. Thinning of the RNFL in one quadrant was seen in 10 patients (41.7%), and thinning in two or more quadrants was seen in 8 patients (33.3%). Thinning in the inferior quadrant was most commonly seen and was observed in 12 patients (50%), followed by the temporal quadrant in 8 patients (33.3%), nasal quadrant in 4 patients (16.7%), and the superior quadrant in 4 patients (16.7%).

Conclusions: Among our 24 patients with XLRS, 15 patients (62.5%) showed a thinning of the RNFL in one or more quadrants in at least one eye and 9 patients (37.5%) in both eyes. High-speed, high-resolution FD-OCT may be useful to determine the presence of possible changes in RNFL thickness in patients with XLRS. Reductions in RNFL thickness in such patients could be relevant in their selection for future therapeutic trials.

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Related in: MedlinePlus

Thinning of the superior, inferior, and temporal quadrants of the RNFL in the right eye of a patient with XLRS. All 4 segments in the temporal quadrant are thin while 2 of 4 in the superior and inferior quadrants are thin.
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Figure 2: Thinning of the superior, inferior, and temporal quadrants of the RNFL in the right eye of a patient with XLRS. All 4 segments in the temporal quadrant are thin while 2 of 4 in the superior and inferior quadrants are thin.

Mentions: RNFL thickness was measured automatically by the existing software at a diameter of 3.45 mm around the center of the optic disc. The total number of A-scans at that circumference was 9510. RNFL thickness was measured in the superior (46°-135°), nasal (316°-45° for the right and 136°- 225° for the left), inferior (226°-315°), and temporal (136°- 225° for the right and 316°-45°for the left) quadrants. OCT software automatically measured 4 smaller segments within each quadrant (Figs 1-2). Data thus obtained were compared with the normative database provided with the software, taking the patient age and size of the optic disc into account.


Retinal nerve fibre layer thickness analysis in X-linked retinoschisis using Fourier-domain OCT.

Genead MA, Pasadhika S, Fishman GA - Eye (Lond) (2009)

Thinning of the superior, inferior, and temporal quadrants of the RNFL in the right eye of a patient with XLRS. All 4 segments in the temporal quadrant are thin while 2 of 4 in the superior and inferior quadrants are thin.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2865150&req=5

Figure 2: Thinning of the superior, inferior, and temporal quadrants of the RNFL in the right eye of a patient with XLRS. All 4 segments in the temporal quadrant are thin while 2 of 4 in the superior and inferior quadrants are thin.
Mentions: RNFL thickness was measured automatically by the existing software at a diameter of 3.45 mm around the center of the optic disc. The total number of A-scans at that circumference was 9510. RNFL thickness was measured in the superior (46°-135°), nasal (316°-45° for the right and 136°- 225° for the left), inferior (226°-315°), and temporal (136°- 225° for the right and 316°-45°for the left) quadrants. OCT software automatically measured 4 smaller segments within each quadrant (Figs 1-2). Data thus obtained were compared with the normative database provided with the software, taking the patient age and size of the optic disc into account.

Bottom Line: A quadrant of the RNFL was considered to be thinned if at least two of the four segments in the quadrant were reduced in thickness.Thinning in the inferior quadrant was most commonly seen and was observed in 12 patients (50%), followed by the temporal quadrant in 8 patients (33.3%), nasal quadrant in 4 patients (16.7%), and the superior quadrant in 4 patients (16.7%).Among our 24 patients with XLRS, 15 patients (62.5%) showed a thinning of the RNFL in one or more quadrants in at least one eye and 9 patients (37.5%) in both eyes.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

ABSTRACT

Purpose: To evaluate the presence of retinal nerve fibre layer (RNFL) defects in patients with X-linked retinoschisis (XLRS) using high-speed, high-resolution, Fourier domain OCT (FD-OCT).

Methods: Twenty-four patients with XLRS seen by the authors were enrolled in the study. All patients underwent a complete eye examination. FD-OCT was performed using Optovue technology. A quadrant of the RNFL was considered to be thinned if at least two of the four segments in the quadrant were reduced in thickness.

Results: The average age of the 24 patients in the study was 28.8+/-14.7 years. Thinning of the RNFL in one quadrant was seen in 10 patients (41.7%), and thinning in two or more quadrants was seen in 8 patients (33.3%). Thinning in the inferior quadrant was most commonly seen and was observed in 12 patients (50%), followed by the temporal quadrant in 8 patients (33.3%), nasal quadrant in 4 patients (16.7%), and the superior quadrant in 4 patients (16.7%).

Conclusions: Among our 24 patients with XLRS, 15 patients (62.5%) showed a thinning of the RNFL in one or more quadrants in at least one eye and 9 patients (37.5%) in both eyes. High-speed, high-resolution FD-OCT may be useful to determine the presence of possible changes in RNFL thickness in patients with XLRS. Reductions in RNFL thickness in such patients could be relevant in their selection for future therapeutic trials.

Show MeSH
Related in: MedlinePlus