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Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus.

Tran N, Mir A, Mallik D, Sinha A, Nayar S, Webster TJ - Int J Nanomedicine (2010)

Bottom Line: In order to study the effects of iron oxide (IO) nanoparticles on Staphylococcus aureus, IO nanoparticles were synthesized via a novel matrix-mediated method using polyvinyl alcohol (PVA).Further, S. aureus were grown in the presence of three different IO nanoparticle concentrations for four, 12, and 24 hours.Live/dead assays were performed and the results provide evidence that IO/PVA nanoparticles inhibited S. aureus growth at the highest concentration (3 mg/mL) at all time points.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Brown University, Providence, Rhode Island, USA.

ABSTRACT
In order to study the effects of iron oxide (IO) nanoparticles on Staphylococcus aureus, IO nanoparticles were synthesized via a novel matrix-mediated method using polyvinyl alcohol (PVA). The IO nanoparticles were characterized by transmission electron microscopy and dynamic light scattering. Further, S. aureus were grown in the presence of three different IO nanoparticle concentrations for four, 12, and 24 hours. Live/dead assays were performed and the results provide evidence that IO/PVA nanoparticles inhibited S. aureus growth at the highest concentration (3 mg/mL) at all time points.

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Related in: MedlinePlus

Transmission electron microscope images of the synthesized IO/PVA nanoparticles. Scale bar = 20 nm.Abbreviations: IO, iron oxide; PVA, polyvinyl alcohol.
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f2-ijn-5-277: Transmission electron microscope images of the synthesized IO/PVA nanoparticles. Scale bar = 20 nm.Abbreviations: IO, iron oxide; PVA, polyvinyl alcohol.

Mentions: TEM images of the synthesized PVA-coated IO nanoparticles (Figure 2) showed that the size of the nanoparticles was 9 nm ± 4 nm. The nanoparticles formed necklace-like chains with a typical length of approximately 100–200 nm. A similar formation was reported in an earlier study, in which IO nanoparticles were believed to precipitate along the polymer chain of PVA.22 The nanoparticle solution was a clear brownish color and no major types of aggregation were visible after months from synthesis.


Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus.

Tran N, Mir A, Mallik D, Sinha A, Nayar S, Webster TJ - Int J Nanomedicine (2010)

Transmission electron microscope images of the synthesized IO/PVA nanoparticles. Scale bar = 20 nm.Abbreviations: IO, iron oxide; PVA, polyvinyl alcohol.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2865022&req=5

f2-ijn-5-277: Transmission electron microscope images of the synthesized IO/PVA nanoparticles. Scale bar = 20 nm.Abbreviations: IO, iron oxide; PVA, polyvinyl alcohol.
Mentions: TEM images of the synthesized PVA-coated IO nanoparticles (Figure 2) showed that the size of the nanoparticles was 9 nm ± 4 nm. The nanoparticles formed necklace-like chains with a typical length of approximately 100–200 nm. A similar formation was reported in an earlier study, in which IO nanoparticles were believed to precipitate along the polymer chain of PVA.22 The nanoparticle solution was a clear brownish color and no major types of aggregation were visible after months from synthesis.

Bottom Line: In order to study the effects of iron oxide (IO) nanoparticles on Staphylococcus aureus, IO nanoparticles were synthesized via a novel matrix-mediated method using polyvinyl alcohol (PVA).Further, S. aureus were grown in the presence of three different IO nanoparticle concentrations for four, 12, and 24 hours.Live/dead assays were performed and the results provide evidence that IO/PVA nanoparticles inhibited S. aureus growth at the highest concentration (3 mg/mL) at all time points.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Brown University, Providence, Rhode Island, USA.

ABSTRACT
In order to study the effects of iron oxide (IO) nanoparticles on Staphylococcus aureus, IO nanoparticles were synthesized via a novel matrix-mediated method using polyvinyl alcohol (PVA). The IO nanoparticles were characterized by transmission electron microscopy and dynamic light scattering. Further, S. aureus were grown in the presence of three different IO nanoparticle concentrations for four, 12, and 24 hours. Live/dead assays were performed and the results provide evidence that IO/PVA nanoparticles inhibited S. aureus growth at the highest concentration (3 mg/mL) at all time points.

Show MeSH
Related in: MedlinePlus