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Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus.

Tran N, Mir A, Mallik D, Sinha A, Nayar S, Webster TJ - Int J Nanomedicine (2010)

Bottom Line: In order to study the effects of iron oxide (IO) nanoparticles on Staphylococcus aureus, IO nanoparticles were synthesized via a novel matrix-mediated method using polyvinyl alcohol (PVA).Further, S. aureus were grown in the presence of three different IO nanoparticle concentrations for four, 12, and 24 hours.Live/dead assays were performed and the results provide evidence that IO/PVA nanoparticles inhibited S. aureus growth at the highest concentration (3 mg/mL) at all time points.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Brown University, Providence, Rhode Island, USA.

ABSTRACT
In order to study the effects of iron oxide (IO) nanoparticles on Staphylococcus aureus, IO nanoparticles were synthesized via a novel matrix-mediated method using polyvinyl alcohol (PVA). The IO nanoparticles were characterized by transmission electron microscopy and dynamic light scattering. Further, S. aureus were grown in the presence of three different IO nanoparticle concentrations for four, 12, and 24 hours. Live/dead assays were performed and the results provide evidence that IO/PVA nanoparticles inhibited S. aureus growth at the highest concentration (3 mg/mL) at all time points.

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A simplified design for a magnetic drug delivery system in which magnetic nanoparticles coated with drugs are directed to infection sites by an external magnetic field.
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f1-ijn-5-277: A simplified design for a magnetic drug delivery system in which magnetic nanoparticles coated with drugs are directed to infection sites by an external magnetic field.

Mentions: Iron oxide (IO) has been widely used in biomedical research because of its biocompatibility and magnetic properties.1,2 Nanoparticles of IO, with sizes less than 100 nm, have been developed as contrast agents for magnetic resonance imaging (MRI),3,4 as hyperthermia agents,5,6 and as carriers for targeted drug delivery to treat several types of cancer.7,8 It is further believed that through the use of magnetic nanoparticles, an optimal drug delivery system can be developed by using an external magnetic field to direct such nanoparticles to desirable sites (such as implant infection) for immediate treatment9 (Figure 1).


Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus.

Tran N, Mir A, Mallik D, Sinha A, Nayar S, Webster TJ - Int J Nanomedicine (2010)

A simplified design for a magnetic drug delivery system in which magnetic nanoparticles coated with drugs are directed to infection sites by an external magnetic field.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2865022&req=5

f1-ijn-5-277: A simplified design for a magnetic drug delivery system in which magnetic nanoparticles coated with drugs are directed to infection sites by an external magnetic field.
Mentions: Iron oxide (IO) has been widely used in biomedical research because of its biocompatibility and magnetic properties.1,2 Nanoparticles of IO, with sizes less than 100 nm, have been developed as contrast agents for magnetic resonance imaging (MRI),3,4 as hyperthermia agents,5,6 and as carriers for targeted drug delivery to treat several types of cancer.7,8 It is further believed that through the use of magnetic nanoparticles, an optimal drug delivery system can be developed by using an external magnetic field to direct such nanoparticles to desirable sites (such as implant infection) for immediate treatment9 (Figure 1).

Bottom Line: In order to study the effects of iron oxide (IO) nanoparticles on Staphylococcus aureus, IO nanoparticles were synthesized via a novel matrix-mediated method using polyvinyl alcohol (PVA).Further, S. aureus were grown in the presence of three different IO nanoparticle concentrations for four, 12, and 24 hours.Live/dead assays were performed and the results provide evidence that IO/PVA nanoparticles inhibited S. aureus growth at the highest concentration (3 mg/mL) at all time points.

View Article: PubMed Central - PubMed

Affiliation: Department of Physics, Brown University, Providence, Rhode Island, USA.

ABSTRACT
In order to study the effects of iron oxide (IO) nanoparticles on Staphylococcus aureus, IO nanoparticles were synthesized via a novel matrix-mediated method using polyvinyl alcohol (PVA). The IO nanoparticles were characterized by transmission electron microscopy and dynamic light scattering. Further, S. aureus were grown in the presence of three different IO nanoparticle concentrations for four, 12, and 24 hours. Live/dead assays were performed and the results provide evidence that IO/PVA nanoparticles inhibited S. aureus growth at the highest concentration (3 mg/mL) at all time points.

Show MeSH
Related in: MedlinePlus