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A preliminary study of the use of bioimpedance in the screening of squamous tongue cancer.

Ching CT, Sun TP, Huang SH, Hsiao CS, Chang CH, Huang SY, Chen YJ, Cheng CS, Shieh HL, Chen CY - Int J Nanomedicine (2010)

Bottom Line: A significant difference (P < 0.05 for the four measurement parameters) was found at 50kHz between CTT and surrounding NTT.It was also found that Z and R of CTT were generally smaller than that of surrounding NTT.In conclusion, bioimpedance at a particular frequency is a potentially promising technique for tongue cancer screening.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou, Taiwan.

ABSTRACT
Oral cancers are the 11th most common malignancy reported worldwide, accounting for 3% of all newly diagnosed cancer cases, and one with high mortality ratios among all malignancies. The objective of this study was to study the electrical properties of cancerous tongue tissue (CTT) and normal tongue tissue (NTT). Five tongue cancer patients participated in this study. A disposable probe incorporating four silver electrodes was used to measure the electrical properties of CTT and the surrounding NTT of patients. Measurements were performed at six frequencies: 20 Hz; 50 kHz; 1.3 MHz; 2.5 MHz; 3.7 MHz; and 5 MHz, with the amplitude of the applied voltage limited to 200mV. Four measurement parameters of impedance (Z), phase angle (theta), real part of impedance (R), and imaginary part of impedance (X) of tongue tissue were assessed to see if there was any significant difference in the values obtained in CTT and surrounding NTT. The intraclass correlation coefficient showed that all measurements were reliable. A significant difference (P < 0.05 for the four measurement parameters) was found at 50kHz between CTT and surrounding NTT. It was also found that Z and R of CTT were generally smaller than that of surrounding NTT. In conclusion, bioimpedance at a particular frequency is a potentially promising technique for tongue cancer screening.

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Related in: MedlinePlus

The four-electrode disposable probe.
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f1-ijn-5-213: The four-electrode disposable probe.

Mentions: Four electrical properties of tongue tissue were measured and they were: impedance (Z); phase angle (θ); real part of impedance (R); and imaginary part of impedance (X). Measurements were made using a disposable probe (Figure 1) with four 1-mm-diameter silver electrodes (2 mm between electrode centers) mounted in square configuration on a plastic bar (5 mm width × 3 mm thick × 100 mm long). The disposable probe was connected to an impedance analyzer (Precision Impedance Analyzer WK6420C, Wayne Kerr Electronics Ltd, Chichester, UK) for all measurements. On the other hand, the probe was evaluated in saline of known electrical conductivity and had an accuracy of ± 0.2Ω on measuring resistance.


A preliminary study of the use of bioimpedance in the screening of squamous tongue cancer.

Ching CT, Sun TP, Huang SH, Hsiao CS, Chang CH, Huang SY, Chen YJ, Cheng CS, Shieh HL, Chen CY - Int J Nanomedicine (2010)

The four-electrode disposable probe.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2865016&req=5

f1-ijn-5-213: The four-electrode disposable probe.
Mentions: Four electrical properties of tongue tissue were measured and they were: impedance (Z); phase angle (θ); real part of impedance (R); and imaginary part of impedance (X). Measurements were made using a disposable probe (Figure 1) with four 1-mm-diameter silver electrodes (2 mm between electrode centers) mounted in square configuration on a plastic bar (5 mm width × 3 mm thick × 100 mm long). The disposable probe was connected to an impedance analyzer (Precision Impedance Analyzer WK6420C, Wayne Kerr Electronics Ltd, Chichester, UK) for all measurements. On the other hand, the probe was evaluated in saline of known electrical conductivity and had an accuracy of ± 0.2Ω on measuring resistance.

Bottom Line: A significant difference (P < 0.05 for the four measurement parameters) was found at 50kHz between CTT and surrounding NTT.It was also found that Z and R of CTT were generally smaller than that of surrounding NTT.In conclusion, bioimpedance at a particular frequency is a potentially promising technique for tongue cancer screening.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou, Taiwan.

ABSTRACT
Oral cancers are the 11th most common malignancy reported worldwide, accounting for 3% of all newly diagnosed cancer cases, and one with high mortality ratios among all malignancies. The objective of this study was to study the electrical properties of cancerous tongue tissue (CTT) and normal tongue tissue (NTT). Five tongue cancer patients participated in this study. A disposable probe incorporating four silver electrodes was used to measure the electrical properties of CTT and the surrounding NTT of patients. Measurements were performed at six frequencies: 20 Hz; 50 kHz; 1.3 MHz; 2.5 MHz; 3.7 MHz; and 5 MHz, with the amplitude of the applied voltage limited to 200mV. Four measurement parameters of impedance (Z), phase angle (theta), real part of impedance (R), and imaginary part of impedance (X) of tongue tissue were assessed to see if there was any significant difference in the values obtained in CTT and surrounding NTT. The intraclass correlation coefficient showed that all measurements were reliable. A significant difference (P < 0.05 for the four measurement parameters) was found at 50kHz between CTT and surrounding NTT. It was also found that Z and R of CTT were generally smaller than that of surrounding NTT. In conclusion, bioimpedance at a particular frequency is a potentially promising technique for tongue cancer screening.

Show MeSH
Related in: MedlinePlus