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Inflammatory molecules in aqueous humour and on ocular surface and glaucoma surgery outcome.

Cvenkel B, Kopitar AN, Ihan A - Mediators Inflamm. (2010)

Bottom Line: Thirty patients who needed antiglaucomatous surgery were included.Eyes with trabeculectomy failure at 3 months showed significantly higher TNF-alpha and IL-6 levels in the aqueous than eyes with successful surgery.Increased expression of HLA-DR on epithelial cells and antigen-presenting cells was not associated with the trabeculectomy outcome.

View Article: PubMed Central - PubMed

Affiliation: Eye Hospital, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.

ABSTRACT

Purpose: To investigate the influence of inflammatory molecules in the aqueous humour and on the ocular surface on the outcome of glaucoma surgery.

Methods: Thirty patients who needed antiglaucomatous surgery were included. The interleukin- (IL-) 8, IL-1beta, IL-6, IL-10, tumour necrosis factor- (TNF-) alpha; and IL-12 were determined from aqueous humour preoperatively and the imprints of conjunctiva were analysed for expression of human leukocyte antigen- (HLA-)-DR after surgery by flow cytometry. The success of trabeculectomy was defined as intraocular pressure less than 21 mmHg without antiglaucoma medication.

Results: Eyes with trabeculectomy failure at 3 months showed significantly higher TNF-alpha and IL-6 levels in the aqueous than eyes with successful surgery. Increased expression of HLA-DR on epithelial cells and antigen-presenting cells was not associated with the trabeculectomy outcome.

Conclusions: Higher preoperative levels of TNF-alpha and IL-6 in aqueous humour may contribute to the development of inflammatory milieu and were associated with worse outcome of glaucoma surgery.

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Related in: MedlinePlus

Aqueous levels of TNF-α in eyes with surgical success and failure 3 months after surgery (P = .025).
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Related In: Results  -  Collection


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fig4: Aqueous levels of TNF-α in eyes with surgical success and failure 3 months after surgery (P = .025).

Mentions: Aqueous levels of cytokines in the eyes with surgical success and failure are summarized in Table 3. We found significantly higher levels of IL-6 and TNF-α in eyes with surgical failure when compared to the eyes with surgical success (Figures 3 and 4).


Inflammatory molecules in aqueous humour and on ocular surface and glaucoma surgery outcome.

Cvenkel B, Kopitar AN, Ihan A - Mediators Inflamm. (2010)

Aqueous levels of TNF-α in eyes with surgical success and failure 3 months after surgery (P = .025).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2864908&req=5

fig4: Aqueous levels of TNF-α in eyes with surgical success and failure 3 months after surgery (P = .025).
Mentions: Aqueous levels of cytokines in the eyes with surgical success and failure are summarized in Table 3. We found significantly higher levels of IL-6 and TNF-α in eyes with surgical failure when compared to the eyes with surgical success (Figures 3 and 4).

Bottom Line: Thirty patients who needed antiglaucomatous surgery were included.Eyes with trabeculectomy failure at 3 months showed significantly higher TNF-alpha and IL-6 levels in the aqueous than eyes with successful surgery.Increased expression of HLA-DR on epithelial cells and antigen-presenting cells was not associated with the trabeculectomy outcome.

View Article: PubMed Central - PubMed

Affiliation: Eye Hospital, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.

ABSTRACT

Purpose: To investigate the influence of inflammatory molecules in the aqueous humour and on the ocular surface on the outcome of glaucoma surgery.

Methods: Thirty patients who needed antiglaucomatous surgery were included. The interleukin- (IL-) 8, IL-1beta, IL-6, IL-10, tumour necrosis factor- (TNF-) alpha; and IL-12 were determined from aqueous humour preoperatively and the imprints of conjunctiva were analysed for expression of human leukocyte antigen- (HLA-)-DR after surgery by flow cytometry. The success of trabeculectomy was defined as intraocular pressure less than 21 mmHg without antiglaucoma medication.

Results: Eyes with trabeculectomy failure at 3 months showed significantly higher TNF-alpha and IL-6 levels in the aqueous than eyes with successful surgery. Increased expression of HLA-DR on epithelial cells and antigen-presenting cells was not associated with the trabeculectomy outcome.

Conclusions: Higher preoperative levels of TNF-alpha and IL-6 in aqueous humour may contribute to the development of inflammatory milieu and were associated with worse outcome of glaucoma surgery.

Show MeSH
Related in: MedlinePlus