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68Ga-chloride PET reveals human pancreatic adenocarcinoma xenografts in rats--comparison with FDG.

Ujula T, Salomäki S, Autio A, Luoto P, Tolvanen T, Lehikoinen P, Viljanen T, Sipilä H, Härkönen P, Roivainen A - Mol Imaging Biol (2009)

Bottom Line: The aim of the study was to compare (68)Ga-chloride with 2-[(18)F]fluoro-2-deoxy-D: -glucose (FDG) for the imaging of pancreatic xenografts.Ex vivo studies showed tumor-to-muscle ratio of 4.0 +/- 0.3 for (68)Ga-chloride (n = 4) and 7.9 +/- 3.2 for FDG (n = 4). (68)Ga-chloride delineated subcutaneously implanted pancreatic adenocarcinoma xenografts by PET, but the uptake was lower than FDG.Further studies to clarify the value of (68)Ga-chloride for PET imaging of tumors are warranted.

View Article: PubMed Central - PubMed

Affiliation: Turku PET Centre, Turku University Hospital, 20521, Turku, Finland.

ABSTRACT

Purpose: The aim of the study was to compare (68)Ga-chloride with 2-[(18)F]fluoro-2-deoxy-D: -glucose (FDG) for the imaging of pancreatic xenografts.

Procedures: Rats with subcutaneous human pancreatic adenocarcinoma xenografts were evaluated in vivo by dynamic positron emission tomography (PET) and ex vivo by measuring radioactivity of excised tissues and by digital autoradiography of tumor cryosections.

Results: Both tracers were capable of delineating all subcutaneous tumors from surrounding tissues by PET. The standardized uptake values of tumors by PET were 0.9 +/- 0.3 (mean +/- SD) for (68)Ga-chloride (n = 13) and 1.8 +/- 1.2 for FDG (n = 11). Ex vivo studies showed tumor-to-muscle ratio of 4.0 +/- 0.3 for (68)Ga-chloride (n = 4) and 7.9 +/- 3.2 for FDG (n = 4).

Conclusions: (68)Ga-chloride delineated subcutaneously implanted pancreatic adenocarcinoma xenografts by PET, but the uptake was lower than FDG. Further studies to clarify the value of (68)Ga-chloride for PET imaging of tumors are warranted.

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In vivo biokinetics (amount of radioactivity vs. time after injection) of intravenously administered 68Ga-chloride and FDG in the rat’s a heart, b liver, c kidney, and d urinary bladder. Radioactivity concentrations are expressed as standardized uptake values (SUV) vs. time after injection (minute). Mean value of 11 to 13 experiments.
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Fig3: In vivo biokinetics (amount of radioactivity vs. time after injection) of intravenously administered 68Ga-chloride and FDG in the rat’s a heart, b liver, c kidney, and d urinary bladder. Radioactivity concentrations are expressed as standardized uptake values (SUV) vs. time after injection (minute). Mean value of 11 to 13 experiments.

Mentions: In case of 68Ga-chloride, the excess of radioactivity was distributed into heart, liver, and urinary bladder. The critical organs for FDG distribution were heart and urinary bladder (Fig. 1a, b). The corresponding tissue TACs are shown in Fig. 3.Fig. 3


68Ga-chloride PET reveals human pancreatic adenocarcinoma xenografts in rats--comparison with FDG.

Ujula T, Salomäki S, Autio A, Luoto P, Tolvanen T, Lehikoinen P, Viljanen T, Sipilä H, Härkönen P, Roivainen A - Mol Imaging Biol (2009)

In vivo biokinetics (amount of radioactivity vs. time after injection) of intravenously administered 68Ga-chloride and FDG in the rat’s a heart, b liver, c kidney, and d urinary bladder. Radioactivity concentrations are expressed as standardized uptake values (SUV) vs. time after injection (minute). Mean value of 11 to 13 experiments.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2864902&req=5

Fig3: In vivo biokinetics (amount of radioactivity vs. time after injection) of intravenously administered 68Ga-chloride and FDG in the rat’s a heart, b liver, c kidney, and d urinary bladder. Radioactivity concentrations are expressed as standardized uptake values (SUV) vs. time after injection (minute). Mean value of 11 to 13 experiments.
Mentions: In case of 68Ga-chloride, the excess of radioactivity was distributed into heart, liver, and urinary bladder. The critical organs for FDG distribution were heart and urinary bladder (Fig. 1a, b). The corresponding tissue TACs are shown in Fig. 3.Fig. 3

Bottom Line: The aim of the study was to compare (68)Ga-chloride with 2-[(18)F]fluoro-2-deoxy-D: -glucose (FDG) for the imaging of pancreatic xenografts.Ex vivo studies showed tumor-to-muscle ratio of 4.0 +/- 0.3 for (68)Ga-chloride (n = 4) and 7.9 +/- 3.2 for FDG (n = 4). (68)Ga-chloride delineated subcutaneously implanted pancreatic adenocarcinoma xenografts by PET, but the uptake was lower than FDG.Further studies to clarify the value of (68)Ga-chloride for PET imaging of tumors are warranted.

View Article: PubMed Central - PubMed

Affiliation: Turku PET Centre, Turku University Hospital, 20521, Turku, Finland.

ABSTRACT

Purpose: The aim of the study was to compare (68)Ga-chloride with 2-[(18)F]fluoro-2-deoxy-D: -glucose (FDG) for the imaging of pancreatic xenografts.

Procedures: Rats with subcutaneous human pancreatic adenocarcinoma xenografts were evaluated in vivo by dynamic positron emission tomography (PET) and ex vivo by measuring radioactivity of excised tissues and by digital autoradiography of tumor cryosections.

Results: Both tracers were capable of delineating all subcutaneous tumors from surrounding tissues by PET. The standardized uptake values of tumors by PET were 0.9 +/- 0.3 (mean +/- SD) for (68)Ga-chloride (n = 13) and 1.8 +/- 1.2 for FDG (n = 11). Ex vivo studies showed tumor-to-muscle ratio of 4.0 +/- 0.3 for (68)Ga-chloride (n = 4) and 7.9 +/- 3.2 for FDG (n = 4).

Conclusions: (68)Ga-chloride delineated subcutaneously implanted pancreatic adenocarcinoma xenografts by PET, but the uptake was lower than FDG. Further studies to clarify the value of (68)Ga-chloride for PET imaging of tumors are warranted.

Show MeSH
Related in: MedlinePlus