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Cellular density evaluation for malignant lymphoma using equivalent cross-relaxation rate imaging - initial experience.

Nishiofuku H, Matsushima S, Inaba Y, Yamaura H, Sato Y, Morishima Y, Kichikawa K - Korean J Radiol (2010)

Bottom Line: Institutional Review Board approval was obtained and all patients provided informed consent.All patients underwent ECR imaging and the offset frequency was set at 7 ppm.The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Nara Medical University, Kashihara, Nara, Japan. nishiofukuhideyuki@yahoo.co.jp

ABSTRACT

Objective: Equivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML).

Materials and methods: Institutional Review Board approval was obtained and all patients provided informed consent. The study subjects included 15 patients with untreated ML who were histologically diagnosed with follicular lymphoma (FL; n = 8) or diffuse large B-cell lymphoma (DLBCL; n = 7). All patients underwent ECR imaging and the offset frequency was set at 7 ppm.

Results: The median ECR values were 71% (range; 60.7 to 75.5) in FL and 54% (50.8 to 59.4) in DLBCL (p = 0.001). The median cellular density was 1.5 +/- 0.17 x 10(6) / mm(2) in FL and 1.0 +/- 0.70 x 10(6) / mm(2) in DLBCL (p = 0.001). The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001). In FL and DLBCL, assuming ECR value cut-off points of 60%, both sensitivity and specificity were 100%.

Conclusion: A strong correlation between ECR and cellular density in ML is demonstrated and the ECR may be a useful technique to differentiate between FL and DLBCL.

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Related in: MedlinePlus

Equivalent cross-relaxation rate (ECR) and cellular density. Regression graph: cellular density is plotted along vertical axis, while equivalent cross-relaxation rate is plotted on horizontal axis. Linear relationship was observed with correlation coefficient of 0.88 (Y = 0.028, X-0.49). ML = malignant lymphoma
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Figure 5: Equivalent cross-relaxation rate (ECR) and cellular density. Regression graph: cellular density is plotted along vertical axis, while equivalent cross-relaxation rate is plotted on horizontal axis. Linear relationship was observed with correlation coefficient of 0.88 (Y = 0.028, X-0.49). ML = malignant lymphoma

Mentions: In Figure 3, Hematoxylin and Eosin stain showed the photomicrographs of FL and DLBCL. Pathologic images in FL revealed intermingled neoplastic cells and normal lymphocytes, while those in DLBCL were almost completely filled with neoplastic large cells and fibrosis (Fig. 3). Box plots of the cellular density data for FL and DLBCL indicated that the median cellular density was 1.51 ± 0.17 × 106 / mm2 for FL and 1.03 ± 0.70 × 106 / mm2 for DLBCL (Fig. 4). A statistically significant difference was observed between FL and DLBCL (p = 0.001). In Figure 5, a correlation between ECR and cellular density in ML was demonstrated, in which the symbol ▪ represents ML. The regression line was determined using cellular density as the outcome variable (Y) and ECR values as the predictor variable (X). The regression line equation was the following: Y= 0.028X-0.49 for ML. The regression graph indicated a linear relationship between the ECR values and cellular density; the correlation coefficient and p value were 0.88 and p = 0.001, respectively.


Cellular density evaluation for malignant lymphoma using equivalent cross-relaxation rate imaging - initial experience.

Nishiofuku H, Matsushima S, Inaba Y, Yamaura H, Sato Y, Morishima Y, Kichikawa K - Korean J Radiol (2010)

Equivalent cross-relaxation rate (ECR) and cellular density. Regression graph: cellular density is plotted along vertical axis, while equivalent cross-relaxation rate is plotted on horizontal axis. Linear relationship was observed with correlation coefficient of 0.88 (Y = 0.028, X-0.49). ML = malignant lymphoma
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2864860&req=5

Figure 5: Equivalent cross-relaxation rate (ECR) and cellular density. Regression graph: cellular density is plotted along vertical axis, while equivalent cross-relaxation rate is plotted on horizontal axis. Linear relationship was observed with correlation coefficient of 0.88 (Y = 0.028, X-0.49). ML = malignant lymphoma
Mentions: In Figure 3, Hematoxylin and Eosin stain showed the photomicrographs of FL and DLBCL. Pathologic images in FL revealed intermingled neoplastic cells and normal lymphocytes, while those in DLBCL were almost completely filled with neoplastic large cells and fibrosis (Fig. 3). Box plots of the cellular density data for FL and DLBCL indicated that the median cellular density was 1.51 ± 0.17 × 106 / mm2 for FL and 1.03 ± 0.70 × 106 / mm2 for DLBCL (Fig. 4). A statistically significant difference was observed between FL and DLBCL (p = 0.001). In Figure 5, a correlation between ECR and cellular density in ML was demonstrated, in which the symbol ▪ represents ML. The regression line was determined using cellular density as the outcome variable (Y) and ECR values as the predictor variable (X). The regression line equation was the following: Y= 0.028X-0.49 for ML. The regression graph indicated a linear relationship between the ECR values and cellular density; the correlation coefficient and p value were 0.88 and p = 0.001, respectively.

Bottom Line: Institutional Review Board approval was obtained and all patients provided informed consent.All patients underwent ECR imaging and the offset frequency was set at 7 ppm.The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Nara Medical University, Kashihara, Nara, Japan. nishiofukuhideyuki@yahoo.co.jp

ABSTRACT

Objective: Equivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML).

Materials and methods: Institutional Review Board approval was obtained and all patients provided informed consent. The study subjects included 15 patients with untreated ML who were histologically diagnosed with follicular lymphoma (FL; n = 8) or diffuse large B-cell lymphoma (DLBCL; n = 7). All patients underwent ECR imaging and the offset frequency was set at 7 ppm.

Results: The median ECR values were 71% (range; 60.7 to 75.5) in FL and 54% (50.8 to 59.4) in DLBCL (p = 0.001). The median cellular density was 1.5 +/- 0.17 x 10(6) / mm(2) in FL and 1.0 +/- 0.70 x 10(6) / mm(2) in DLBCL (p = 0.001). The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001). In FL and DLBCL, assuming ECR value cut-off points of 60%, both sensitivity and specificity were 100%.

Conclusion: A strong correlation between ECR and cellular density in ML is demonstrated and the ECR may be a useful technique to differentiate between FL and DLBCL.

Show MeSH
Related in: MedlinePlus