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Tracing the evolution of tissue identity with microRNAs.

De Mulder K, Berezikov E - Genome Biol. (2010)

Bottom Line: Comparison of microRNA expression identified tissues present in the last common ancestor of Bilaterians and put evolution of microRNAs in the context of tissue evolution.

View Article: PubMed Central - HTML - PubMed

Affiliation: Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands.

ABSTRACT
Comparison of microRNA expression identified tissues present in the last common ancestor of Bilaterians and put evolution of microRNAs in the context of tissue evolution.

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Related in: MedlinePlus

Phylogenetic relationships between major taxonomic phyla according to [9] and reconstruction of ancestral tissue types based on conserved miRNA expression patterns. NLCA, BLCA and ELCA: the Nephrozoan, Bilaterian and Eumetazoan last common ancestor, respectively. The summary for the BLCA is preliminary owing to the absence of a sequenced acoel genome and miRNA expression data. Representatives of the taxa used in the study of Christodoulou et al. [8] are in bold.
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Figure 1: Phylogenetic relationships between major taxonomic phyla according to [9] and reconstruction of ancestral tissue types based on conserved miRNA expression patterns. NLCA, BLCA and ELCA: the Nephrozoan, Bilaterian and Eumetazoan last common ancestor, respectively. The summary for the BLCA is preliminary owing to the absence of a sequenced acoel genome and miRNA expression data. Representatives of the taxa used in the study of Christodoulou et al. [8] are in bold.

Mentions: In a recent study, Christodoulou et al. [8] have begun to assess the correlation between expression patterns of ancient miRNAs and body-plan evolution in Bilateria. The Bilateria mainly consists of protostomes and deuterostomes, which are collectively called nephrozoans, plus a few basal phyla, such as acoels, nemertodermatids and chaetognaths (Figure 1). In their comparative approach, Christodoulou et al. [8] focused on miRNAs conserved between the two major superphyla within the Bilateria - protostomes (for example, arthropods, nematodes and molluscs) and deuterostomes (for example, vertebrates and echinoderms). The authors hypothesized that any specific localization shared between protostomes and deuterostomes should reflect an ancient specificity of that miRNA in their last common ancestor. To address this question, they used the annelids Platynereis dumerilii and Capitella sp. (new representatives of the understudied lophotrochozoan protostomes) and the sea urchin Strongylocentrotus purpuratus (basal representative of the deuterostomes), with the cnidarian Nematostella vectensis as an outgroup for the Bilateria.


Tracing the evolution of tissue identity with microRNAs.

De Mulder K, Berezikov E - Genome Biol. (2010)

Phylogenetic relationships between major taxonomic phyla according to [9] and reconstruction of ancestral tissue types based on conserved miRNA expression patterns. NLCA, BLCA and ELCA: the Nephrozoan, Bilaterian and Eumetazoan last common ancestor, respectively. The summary for the BLCA is preliminary owing to the absence of a sequenced acoel genome and miRNA expression data. Representatives of the taxa used in the study of Christodoulou et al. [8] are in bold.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2864561&req=5

Figure 1: Phylogenetic relationships between major taxonomic phyla according to [9] and reconstruction of ancestral tissue types based on conserved miRNA expression patterns. NLCA, BLCA and ELCA: the Nephrozoan, Bilaterian and Eumetazoan last common ancestor, respectively. The summary for the BLCA is preliminary owing to the absence of a sequenced acoel genome and miRNA expression data. Representatives of the taxa used in the study of Christodoulou et al. [8] are in bold.
Mentions: In a recent study, Christodoulou et al. [8] have begun to assess the correlation between expression patterns of ancient miRNAs and body-plan evolution in Bilateria. The Bilateria mainly consists of protostomes and deuterostomes, which are collectively called nephrozoans, plus a few basal phyla, such as acoels, nemertodermatids and chaetognaths (Figure 1). In their comparative approach, Christodoulou et al. [8] focused on miRNAs conserved between the two major superphyla within the Bilateria - protostomes (for example, arthropods, nematodes and molluscs) and deuterostomes (for example, vertebrates and echinoderms). The authors hypothesized that any specific localization shared between protostomes and deuterostomes should reflect an ancient specificity of that miRNA in their last common ancestor. To address this question, they used the annelids Platynereis dumerilii and Capitella sp. (new representatives of the understudied lophotrochozoan protostomes) and the sea urchin Strongylocentrotus purpuratus (basal representative of the deuterostomes), with the cnidarian Nematostella vectensis as an outgroup for the Bilateria.

Bottom Line: Comparison of microRNA expression identified tissues present in the last common ancestor of Bilaterians and put evolution of microRNAs in the context of tissue evolution.

View Article: PubMed Central - HTML - PubMed

Affiliation: Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands.

ABSTRACT
Comparison of microRNA expression identified tissues present in the last common ancestor of Bilaterians and put evolution of microRNAs in the context of tissue evolution.

Show MeSH
Related in: MedlinePlus