Limits...
Photoacoustic ophthalmoscopy for in vivo retinal imaging.

Jiao S, Jiang M, Hu J, Fawzi A, Zhou Q, Shung KK, Puliafito CA, Zhang HF - Opt Express (2010)

Bottom Line: For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT).By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, which can provide multi-modal retinal imaging simultaneously.The capabilities of this novel technology were demonstrated by imaging both the microanatomy and microvasculature of the rat retina in vivo.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

ABSTRACT
We have developed a non-invasive photoacoustic ophthalmoscopy (PAOM) for in vivo retinal imaging. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high speed. For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT). By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, which can provide multi-modal retinal imaging simultaneously. The capabilities of this novel technology were demonstrated by imaging both the microanatomy and microvasculature of the rat retina in vivo.

Show MeSH

Related in: MedlinePlus

Volumetric visualization and segmentation of PAOM image. (a) (Media 1) showing the imaged retinal structure by PAOM. (b) Segmented PAOM images of the retinal blood vessels. (c) Pseudo-colored PAOM images of the retinal vessels and RPE.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2864517&req=5

g003: Volumetric visualization and segmentation of PAOM image. (a) (Media 1) showing the imaged retinal structure by PAOM. (b) Segmented PAOM images of the retinal blood vessels. (c) Pseudo-colored PAOM images of the retinal vessels and RPE.

Mentions: Figure 3Fig. 3


Photoacoustic ophthalmoscopy for in vivo retinal imaging.

Jiao S, Jiang M, Hu J, Fawzi A, Zhou Q, Shung KK, Puliafito CA, Zhang HF - Opt Express (2010)

Volumetric visualization and segmentation of PAOM image. (a) (Media 1) showing the imaged retinal structure by PAOM. (b) Segmented PAOM images of the retinal blood vessels. (c) Pseudo-colored PAOM images of the retinal vessels and RPE.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2864517&req=5

g003: Volumetric visualization and segmentation of PAOM image. (a) (Media 1) showing the imaged retinal structure by PAOM. (b) Segmented PAOM images of the retinal blood vessels. (c) Pseudo-colored PAOM images of the retinal vessels and RPE.
Mentions: Figure 3Fig. 3

Bottom Line: For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT).By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, which can provide multi-modal retinal imaging simultaneously.The capabilities of this novel technology were demonstrated by imaging both the microanatomy and microvasculature of the rat retina in vivo.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

ABSTRACT
We have developed a non-invasive photoacoustic ophthalmoscopy (PAOM) for in vivo retinal imaging. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high speed. For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT). By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, which can provide multi-modal retinal imaging simultaneously. The capabilities of this novel technology were demonstrated by imaging both the microanatomy and microvasculature of the rat retina in vivo.

Show MeSH
Related in: MedlinePlus