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Fulminant giant cell myocarditis and cardiogenic shock: an unusual presentation of malignant thymoma.

Koul D, Kanwar M, Jefic D, Kolluru A, Singh T, Dhar S, Kumar P, Cohen G - Cardiol Res Pract (2010)

Bottom Line: Malignant thymoma is rarely associated with giant cell myocarditis.We present a case study that illustrates this association and cardiogenic shock with underlying tamponade.The dramatic presentation of this scenario has not been previously described.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Cardiac Cath Laboratory, St. John Hospital and Medical Center, 22101 Moross Road, 2nd Floor VEP, Detroit, MI 48236, USA.

ABSTRACT
Malignant thymoma is rarely associated with giant cell myocarditis. We present a case study that illustrates this association and cardiogenic shock with underlying tamponade. The dramatic presentation of this scenario has not been previously described.

No MeSH data available.


Related in: MedlinePlus

Parasternal long-axis views showing severe baseline LV dysfunction (Figures 4(a) and 4(b)) and improved ejection fraction on the followup study (Figures 4(c) and 4(d)).
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fig4: Parasternal long-axis views showing severe baseline LV dysfunction (Figures 4(a) and 4(b)) and improved ejection fraction on the followup study (Figures 4(c) and 4(d)).

Mentions: Further laboratory evaluation showed elevated acetylcholine receptor antibody, antisarcolemma, and antimyosin antibody titers. Antibody titers of viral etiologies for myocarditis were negative. Steroids and plasmapheresis for thymoma-associated myasthenia gravis resulted in neurological improvement. Patient was taken off of inotropes and IABP. A repeat echocardiogram several days later showed improved LV function with an EF of 45% (Figure 4). Chemotherapy with carboplatin and paclitaxel resulted in good initial response with CT scan showing reduction in thymoma tumor burden. However, hospital course was complicated by febrile neutropenia and sepsis. She died 35 days after hospital admission.


Fulminant giant cell myocarditis and cardiogenic shock: an unusual presentation of malignant thymoma.

Koul D, Kanwar M, Jefic D, Kolluru A, Singh T, Dhar S, Kumar P, Cohen G - Cardiol Res Pract (2010)

Parasternal long-axis views showing severe baseline LV dysfunction (Figures 4(a) and 4(b)) and improved ejection fraction on the followup study (Figures 4(c) and 4(d)).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2864446&req=5

fig4: Parasternal long-axis views showing severe baseline LV dysfunction (Figures 4(a) and 4(b)) and improved ejection fraction on the followup study (Figures 4(c) and 4(d)).
Mentions: Further laboratory evaluation showed elevated acetylcholine receptor antibody, antisarcolemma, and antimyosin antibody titers. Antibody titers of viral etiologies for myocarditis were negative. Steroids and plasmapheresis for thymoma-associated myasthenia gravis resulted in neurological improvement. Patient was taken off of inotropes and IABP. A repeat echocardiogram several days later showed improved LV function with an EF of 45% (Figure 4). Chemotherapy with carboplatin and paclitaxel resulted in good initial response with CT scan showing reduction in thymoma tumor burden. However, hospital course was complicated by febrile neutropenia and sepsis. She died 35 days after hospital admission.

Bottom Line: Malignant thymoma is rarely associated with giant cell myocarditis.We present a case study that illustrates this association and cardiogenic shock with underlying tamponade.The dramatic presentation of this scenario has not been previously described.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Cardiac Cath Laboratory, St. John Hospital and Medical Center, 22101 Moross Road, 2nd Floor VEP, Detroit, MI 48236, USA.

ABSTRACT
Malignant thymoma is rarely associated with giant cell myocarditis. We present a case study that illustrates this association and cardiogenic shock with underlying tamponade. The dramatic presentation of this scenario has not been previously described.

No MeSH data available.


Related in: MedlinePlus