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Primary Klebsiella pneumoniae Liver Abscess with Metastatic Spread to Lung and Eye, a North-European Case Report of an Emerging Syndrome.

Sobirk SK, Struve C, Jacobsson SG - Open Microbiol J (2010)

Bottom Line: A syndrome of community acquired liver abscess caused by highly virulent hypermucoviscous, rmpA positive Klebsiella pneumoniae strains occurs with high incidence in Asia.We here report a case complicated by metastatic infection, to our knowledge, the first one described in Northern Europe.This and other recently reported cases indicate the emergence of this severe syndrome outside of Asia.

View Article: PubMed Central - PubMed

Affiliation: Clinical Microbiology, University and Regional Laboratories Region Skåne s-221 85 Lund, Sweden.

ABSTRACT
A syndrome of community acquired liver abscess caused by highly virulent hypermucoviscous, rmpA positive Klebsiella pneumoniae strains occurs with high incidence in Asia. We here report a case complicated by metastatic infection, to our knowledge, the first one described in Northern Europe. This and other recently reported cases indicate the emergence of this severe syndrome outside of Asia.

No MeSH data available.


Related in: MedlinePlus

Plate culture demonstrating the hypermucoviscous phenotype of the isolate.
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Figure 2: Plate culture demonstrating the hypermucoviscous phenotype of the isolate.

Mentions: The K. pneumoniae isolate that caused the infection was found to express the hypermucoviscous phenotype as shown by the formation of mucoviscous strings when a loop was passed through a colony (Fig. 2). Capsular serotyping at the International Eschericia coli and Klebsiella Reference Centre (WHO), Statens Serum Institut revealed that the isolate belongs to the K1 serotype which was confirmed by detection of the K1 serotype specific gene magA as previously described (Fig. 3) [15]. Furthermore the isolate was positive for all four virulence genes rmpA, aerobactin, kfu and allS as revealed by polymerase chain reaction using specific primers (Fig. 3) [5]. Thus the isolate exhibited similar characteristics as the highly virulent K. pneumoniae isolates that have so far mainly been observed in Asia.


Primary Klebsiella pneumoniae Liver Abscess with Metastatic Spread to Lung and Eye, a North-European Case Report of an Emerging Syndrome.

Sobirk SK, Struve C, Jacobsson SG - Open Microbiol J (2010)

Plate culture demonstrating the hypermucoviscous phenotype of the isolate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2864426&req=5

Figure 2: Plate culture demonstrating the hypermucoviscous phenotype of the isolate.
Mentions: The K. pneumoniae isolate that caused the infection was found to express the hypermucoviscous phenotype as shown by the formation of mucoviscous strings when a loop was passed through a colony (Fig. 2). Capsular serotyping at the International Eschericia coli and Klebsiella Reference Centre (WHO), Statens Serum Institut revealed that the isolate belongs to the K1 serotype which was confirmed by detection of the K1 serotype specific gene magA as previously described (Fig. 3) [15]. Furthermore the isolate was positive for all four virulence genes rmpA, aerobactin, kfu and allS as revealed by polymerase chain reaction using specific primers (Fig. 3) [5]. Thus the isolate exhibited similar characteristics as the highly virulent K. pneumoniae isolates that have so far mainly been observed in Asia.

Bottom Line: A syndrome of community acquired liver abscess caused by highly virulent hypermucoviscous, rmpA positive Klebsiella pneumoniae strains occurs with high incidence in Asia.We here report a case complicated by metastatic infection, to our knowledge, the first one described in Northern Europe.This and other recently reported cases indicate the emergence of this severe syndrome outside of Asia.

View Article: PubMed Central - PubMed

Affiliation: Clinical Microbiology, University and Regional Laboratories Region Skåne s-221 85 Lund, Sweden.

ABSTRACT
A syndrome of community acquired liver abscess caused by highly virulent hypermucoviscous, rmpA positive Klebsiella pneumoniae strains occurs with high incidence in Asia. We here report a case complicated by metastatic infection, to our knowledge, the first one described in Northern Europe. This and other recently reported cases indicate the emergence of this severe syndrome outside of Asia.

No MeSH data available.


Related in: MedlinePlus