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Health-related quality of life in patients with severe COPD hospitalized for exacerbations - comparing EQ-5D, SF-12 and SGRQ.

Menn P, Weber N, Holle R - Health Qual Life Outcomes (2010)

Bottom Line: Completeness was best for EQ-5D and SGRQ, while no utility value for the SF-12 could be calculated for more than 30%.Properties of the SGRQ were satisfactory.However, since no utility values can be derived from this disease-specific instrument, it is not suitable for cost-utility analyses in health-economic evaluations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Health Economics and Health Care Management, Neuherberg, Germany. petra.menn@helmholtz-muenchen.de

ABSTRACT

Background: The aim of this study was to measure HrQoL during acute exacerbations of COPD using generic and disease-specific instruments, and to assess completeness, proportion with best or worst health state, sensitivity to change and discriminative ability for each instrument.

Methods: EQ-5D, SF-12 and SGRQ were obtained from COPD patients with GOLD stage III and IV hospitalized for an acute exacerbation both at admission and discharge. To assess the instruments' properties, utility values were calculated for EQ-5D and SF-12, and a total score was derived from the SGRQ.

Results: Mean utilities ranged from 0.54 (SF-12, stage IV) to 0.62 (EQ-5D, stage III) at admission, and from 0.58 (SF-12, stage IV) to 0.84 (EQ-5D, stage III) at discharge. Completeness was best for EQ-5D and SGRQ, while no utility value for the SF-12 could be calculated for more than 30%. For SGRQ subscales, the minimal score occurred in up to 11% at admission, while full health was observed for the EQ-5D at discharge in 13%. Sensitivity to change was generally good, whereas discrimination between COPD stages was low for the EQ-5D.

Conclusions: Acute exacerbations seriously impair health status and quality of life. The EQ-5D is generally suitable to measure HrQoL in exacerbations of severe COPD, although the high proportion of patients reporting full health at discharge poses a problem. The main issue with the SF-12 is the high proportion of missing values in a self-assessed setting. Properties of the SGRQ were satisfactory. However, since no utility values can be derived from this disease-specific instrument, it is not suitable for cost-utility analyses in health-economic evaluations.

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Related in: MedlinePlus

HrQoL by disease severity and time of assessment for the 3 instruments. Adm.: Admission; Dis.: Discharge.
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Figure 1: HrQoL by disease severity and time of assessment for the 3 instruments. Adm.: Admission; Dis.: Discharge.

Mentions: Figure 1 shows boxplots of the utility and total scores, respectively, at admission and discharge by disease severity for the 3 instruments.


Health-related quality of life in patients with severe COPD hospitalized for exacerbations - comparing EQ-5D, SF-12 and SGRQ.

Menn P, Weber N, Holle R - Health Qual Life Outcomes (2010)

HrQoL by disease severity and time of assessment for the 3 instruments. Adm.: Admission; Dis.: Discharge.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2864208&req=5

Figure 1: HrQoL by disease severity and time of assessment for the 3 instruments. Adm.: Admission; Dis.: Discharge.
Mentions: Figure 1 shows boxplots of the utility and total scores, respectively, at admission and discharge by disease severity for the 3 instruments.

Bottom Line: Completeness was best for EQ-5D and SGRQ, while no utility value for the SF-12 could be calculated for more than 30%.Properties of the SGRQ were satisfactory.However, since no utility values can be derived from this disease-specific instrument, it is not suitable for cost-utility analyses in health-economic evaluations.

View Article: PubMed Central - HTML - PubMed

Affiliation: Helmholtz Zentrum München - German Research Center for Environmental Health, Institute of Health Economics and Health Care Management, Neuherberg, Germany. petra.menn@helmholtz-muenchen.de

ABSTRACT

Background: The aim of this study was to measure HrQoL during acute exacerbations of COPD using generic and disease-specific instruments, and to assess completeness, proportion with best or worst health state, sensitivity to change and discriminative ability for each instrument.

Methods: EQ-5D, SF-12 and SGRQ were obtained from COPD patients with GOLD stage III and IV hospitalized for an acute exacerbation both at admission and discharge. To assess the instruments' properties, utility values were calculated for EQ-5D and SF-12, and a total score was derived from the SGRQ.

Results: Mean utilities ranged from 0.54 (SF-12, stage IV) to 0.62 (EQ-5D, stage III) at admission, and from 0.58 (SF-12, stage IV) to 0.84 (EQ-5D, stage III) at discharge. Completeness was best for EQ-5D and SGRQ, while no utility value for the SF-12 could be calculated for more than 30%. For SGRQ subscales, the minimal score occurred in up to 11% at admission, while full health was observed for the EQ-5D at discharge in 13%. Sensitivity to change was generally good, whereas discrimination between COPD stages was low for the EQ-5D.

Conclusions: Acute exacerbations seriously impair health status and quality of life. The EQ-5D is generally suitable to measure HrQoL in exacerbations of severe COPD, although the high proportion of patients reporting full health at discharge poses a problem. The main issue with the SF-12 is the high proportion of missing values in a self-assessed setting. Properties of the SGRQ were satisfactory. However, since no utility values can be derived from this disease-specific instrument, it is not suitable for cost-utility analyses in health-economic evaluations.

Show MeSH
Related in: MedlinePlus