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The relationship of cerb B 2 expression with estrogen receptor and progesterone receptor and prognostic parameters in endometrial carcinomas.

Gul AE, Keser SH, Barisik NO, Kandemir NO, Cakir C, Sensu S, Karadayi N - Diagn Pathol (2010)

Bottom Line: We could not find a statistically significant relation between c-erbB-2 staining and ER.There was not a statistically significant difference between c-erbB-2 and histological grade.The highest level of c-erbB-2 was found in grade 2 cases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pathology Department, Dr, Lütfi Kirdar Kartal Educational and Research Hospital, Istanbul, Turkey. aylinegegul-34@hotmail.com

ABSTRACT

Background: Endometrial carcinoma (EC) is the most common malignancy of the female genital tract. Gene alterations and overexpression of various oncogenes are important in tumor development. The human HER 2 neu (c-erbB-2) gene product is a transmembrane receptor with an intracellular tyrosine kinase that plays an important role in coordinating the endometrial growth factor receptor signaling network. The aim of this study was to investigate the expression of c-erbB-2 in endometrial cancer, to study its correlation to established prognostic parameters and estrogen receptor (ER) and progesterone receptor (PR) status.

Methods: Immunohistochemical (IHC) analyses of ER, PR and c-erbB-2 were performed in 72 EC cases.

Results: We detected a positive staining with c erbB 2 in 18.1% of the cases and determined a statistically significant relation between c-erbB-2 and PR. We could not find a statistically significant relation between c-erbB-2 staining and ER. There was not a statistically significant difference between c-erbB-2 and histological grade. The highest level of c-erbB-2 was found in grade 2 cases. There was not any statistically significant relation between c-erbB-2 and menstrual status, myometrial invasion, lymph node status, stage and survival.

Conclusions: Although our study provides additional evidence of the potential prognostic role of c-erbB-2, further prospective and controlled studies are required to validate their clinical usefulness.

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Strong immunoreactivity for PR in the endometrial adenocarcinoma (IHC×200).
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Figure 2: Strong immunoreactivity for PR in the endometrial adenocarcinoma (IHC×200).

Mentions: ER positivity was determined in 61 of the 72 cases (84.7%) and PR positivity was determined in 59 of the 72 cases (81.9%) (Figure 2). The proportion of the positive staining between ER and grades (1-2-3) were 24 (96%), 33(84.6%) and 4(50%), respectively. The proportion of the staining was observed but there was not a statistically significant relation between ER and the grades. PR expression was determined relatively high in proportion among the G1 and G2 cases. In G3 cases PR expression ratio was low and it was statistically significant (p < 0.05). Positive staining was observed both in ER and PR in 23 (82.14%) out of the 28 stage I cases. There was only one case in stage II and positive staining was observed both in ER and PR. All of the 5 cases in stage III showed positive staining with ER but only 3 of the cases had positive staining with PR. There was not any statistically significant relations between ER-stage-survival and PR-stage-survival. Nine cases (14.8%) of all with ER positivity and 8 (13.6%) of the cases with PR positivity showed a positive staining with c-erbB-2 staining characteristics are summarized in Table 2, 3 and 4.


The relationship of cerb B 2 expression with estrogen receptor and progesterone receptor and prognostic parameters in endometrial carcinomas.

Gul AE, Keser SH, Barisik NO, Kandemir NO, Cakir C, Sensu S, Karadayi N - Diagn Pathol (2010)

Strong immunoreactivity for PR in the endometrial adenocarcinoma (IHC×200).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2837627&req=5

Figure 2: Strong immunoreactivity for PR in the endometrial adenocarcinoma (IHC×200).
Mentions: ER positivity was determined in 61 of the 72 cases (84.7%) and PR positivity was determined in 59 of the 72 cases (81.9%) (Figure 2). The proportion of the positive staining between ER and grades (1-2-3) were 24 (96%), 33(84.6%) and 4(50%), respectively. The proportion of the staining was observed but there was not a statistically significant relation between ER and the grades. PR expression was determined relatively high in proportion among the G1 and G2 cases. In G3 cases PR expression ratio was low and it was statistically significant (p < 0.05). Positive staining was observed both in ER and PR in 23 (82.14%) out of the 28 stage I cases. There was only one case in stage II and positive staining was observed both in ER and PR. All of the 5 cases in stage III showed positive staining with ER but only 3 of the cases had positive staining with PR. There was not any statistically significant relations between ER-stage-survival and PR-stage-survival. Nine cases (14.8%) of all with ER positivity and 8 (13.6%) of the cases with PR positivity showed a positive staining with c-erbB-2 staining characteristics are summarized in Table 2, 3 and 4.

Bottom Line: We could not find a statistically significant relation between c-erbB-2 staining and ER.There was not a statistically significant difference between c-erbB-2 and histological grade.The highest level of c-erbB-2 was found in grade 2 cases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pathology Department, Dr, Lütfi Kirdar Kartal Educational and Research Hospital, Istanbul, Turkey. aylinegegul-34@hotmail.com

ABSTRACT

Background: Endometrial carcinoma (EC) is the most common malignancy of the female genital tract. Gene alterations and overexpression of various oncogenes are important in tumor development. The human HER 2 neu (c-erbB-2) gene product is a transmembrane receptor with an intracellular tyrosine kinase that plays an important role in coordinating the endometrial growth factor receptor signaling network. The aim of this study was to investigate the expression of c-erbB-2 in endometrial cancer, to study its correlation to established prognostic parameters and estrogen receptor (ER) and progesterone receptor (PR) status.

Methods: Immunohistochemical (IHC) analyses of ER, PR and c-erbB-2 were performed in 72 EC cases.

Results: We detected a positive staining with c erbB 2 in 18.1% of the cases and determined a statistically significant relation between c-erbB-2 and PR. We could not find a statistically significant relation between c-erbB-2 staining and ER. There was not a statistically significant difference between c-erbB-2 and histological grade. The highest level of c-erbB-2 was found in grade 2 cases. There was not any statistically significant relation between c-erbB-2 and menstrual status, myometrial invasion, lymph node status, stage and survival.

Conclusions: Although our study provides additional evidence of the potential prognostic role of c-erbB-2, further prospective and controlled studies are required to validate their clinical usefulness.

Show MeSH
Related in: MedlinePlus