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Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective.

Pate MB, Smith JK, Chi DS, Krishnaswamy G - Clin Mol Allergy (2010)

Bottom Line: The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production.Dysregulation of this process may result in either elevated IgE levels or IgE deficiency.This can often assist in the development of tailored treatments.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Allergy and Immunology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA. krishnas@etsu.edu.

ABSTRACT

Background: Altered levels of Immunoglobulin E (IgE) represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production.

Methods: Articles published in Medline/PubMed were searched with the keyword Immunoglobulin E and specific terms such as class switch recombination, deficiency and/or specific disease conditions (atopy, neoplasia, renal disease, myeloma, etc.). The selected papers included reviews, case reports, retrospective reviews and molecular mechanisms. Studies involving both sexes and all ages were included in the analysis.

Results: Both very low and elevated levels of IgE may be seen in clinical practice. Major advancements have been made in our understanding of the molecular basis of IgE class switching including roles for T cells, cytokines and T regulatory (or Treg) cells in this process. Dysregulation of this process may result in either elevated IgE levels or IgE deficiency.

Conclusion: Evaluation of a patient with elevated IgE must involve a detailed differential diagnosis and consideration of various immunological and non-immunological disorders. The use of appropriate tests will allow the correct diagnosis to be made. This can often assist in the development of tailored treatments.

No MeSH data available.


Related in: MedlinePlus

Potential consequences of IgE hypogammaglobulinemia.
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Figure 6: Potential consequences of IgE hypogammaglobulinemia.

Mentions: The prevalence of autoimmune disease is recognized to be increased in persons with immunoglobulin deficiencies - particularly those with IgA hypogammaglobulinemia [23]. The authors have documented a similar predisposition in AIC patients with deficiencies in IgE [22]. There are potentially a number of mechanisms that could explain this association (Figure 6).


Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective.

Pate MB, Smith JK, Chi DS, Krishnaswamy G - Clin Mol Allergy (2010)

Potential consequences of IgE hypogammaglobulinemia.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2837605&req=5

Figure 6: Potential consequences of IgE hypogammaglobulinemia.
Mentions: The prevalence of autoimmune disease is recognized to be increased in persons with immunoglobulin deficiencies - particularly those with IgA hypogammaglobulinemia [23]. The authors have documented a similar predisposition in AIC patients with deficiencies in IgE [22]. There are potentially a number of mechanisms that could explain this association (Figure 6).

Bottom Line: The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production.Dysregulation of this process may result in either elevated IgE levels or IgE deficiency.This can often assist in the development of tailored treatments.

View Article: PubMed Central - HTML - PubMed

Affiliation: Division of Allergy and Immunology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA. krishnas@etsu.edu.

ABSTRACT

Background: Altered levels of Immunoglobulin E (IgE) represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production.

Methods: Articles published in Medline/PubMed were searched with the keyword Immunoglobulin E and specific terms such as class switch recombination, deficiency and/or specific disease conditions (atopy, neoplasia, renal disease, myeloma, etc.). The selected papers included reviews, case reports, retrospective reviews and molecular mechanisms. Studies involving both sexes and all ages were included in the analysis.

Results: Both very low and elevated levels of IgE may be seen in clinical practice. Major advancements have been made in our understanding of the molecular basis of IgE class switching including roles for T cells, cytokines and T regulatory (or Treg) cells in this process. Dysregulation of this process may result in either elevated IgE levels or IgE deficiency.

Conclusion: Evaluation of a patient with elevated IgE must involve a detailed differential diagnosis and consideration of various immunological and non-immunological disorders. The use of appropriate tests will allow the correct diagnosis to be made. This can often assist in the development of tailored treatments.

No MeSH data available.


Related in: MedlinePlus