Limits...
Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer.

Skipworth RJ, Deans DA, Tan BH, Sangster K, Paterson-Brown S, Brown DA, Hunter M, Breit SN, Ross JA, Fearon KC - Br. J. Cancer (2010)

Bottom Line: However, although MIC-1 correlated weakly with dietary intake (r(2)=0.157; P=0.031), it did not correlate with weight loss, BMI, or anthropometry.Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259-373; P=0.036), but MIC-1 was not an independent prognostic indicator.There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

View Article: PubMed Central - PubMed

Affiliation: University of Edinburgh, Royal Infirmary of Edinburgh, UK.

ABSTRACT

Background: Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).

Methods: Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of > or =10 mg l(-1) or modified Glasgow prognostic score (mGPS) of > or =1), and nutritional status were assessed in newly diagnosed OGC patients (n=293). Healthy volunteers (n=35) served as controls.

Results: MIC-1 was elevated in patients (median=1371 pg ml(-1); range 141-39 053) when compared with controls (median=377 pg ml(-1); range 141-3786; P<0.001). Patients with gastric tumours (median=1592 pg ml(-1); range 141-12 643) showed higher MIC-1 concentrations than patients with junctional (median=1337 pg ml(-1); range 383-39 053) and oesophageal tumours (median=1180 pg ml(-1); range 258-31 184; P=0.015). Patients showed a median weight loss of 6.4% (range 0.0-33.4%), and 42% of patients had an mGPS of > or =1 or plasma CRP of > or =10 mg l(-1) (median=9 mg l(-1); range 1-200). MIC-1 correlated positively with disease stage (r(2)=0.217; P<0.001), age (r(2)=0.332; P<0.001), CRP (r(2)=0.314; P<0.001), and mGPS (r(2)=0.336; P<0.001), and negatively with Karnofsky Performance Score (r(2)=-0.269; P<0.001). However, although MIC-1 correlated weakly with dietary intake (r(2)=0.157; P=0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259-373; P=0.036), but MIC-1 was not an independent prognostic indicator.

Conclusions: There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

Show MeSH

Related in: MedlinePlus

Kaplan–Meier plot of survival of oesophago-gastric cancer patients according to plasma MIC-1 concentration. Patients with MIC-1 concentrations in the upper quartile showed worsened survival (median 204 days; 95% CI 157–251) when compared with patients with MIC-1 concentrations in the lower three quartiles (median 316 days; 95% CI 259–373; P=0.036, log-rank test).
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2837566&req=5

fig7: Kaplan–Meier plot of survival of oesophago-gastric cancer patients according to plasma MIC-1 concentration. Patients with MIC-1 concentrations in the upper quartile showed worsened survival (median 204 days; 95% CI 157–251) when compared with patients with MIC-1 concentrations in the lower three quartiles (median 316 days; 95% CI 259–373; P=0.036, log-rank test).

Mentions: Patients with plasma MIC-1 concentrations in the upper quartile (>2270 pg ml–1) showed worsened survival (median 204 days; 95% CI 157–251) when compared with patients with MIC-1 concentrations in the lower three quartiles (median 316 days; 95% CI 259–373; P=0.036; log-rank test; Figure 7). In Cox's proportional hazards model (incorporating MIC-1, CRP, percentage weight loss, disease stage, tumour grade, patient age, dysphagia score, diet score, and treatment regimen), disease stage (P<0.001), treatment regimen (P=0.003), CRP (P=0.034), and percentage weight loss (P=0.002), but not plasma MIC-1 concentration, were significant determinants of survival (Table 4). Substitution of mGPS for CRP within the model revealed stage, treatment regimen, and weight loss as the only significant determinants.


Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer.

Skipworth RJ, Deans DA, Tan BH, Sangster K, Paterson-Brown S, Brown DA, Hunter M, Breit SN, Ross JA, Fearon KC - Br. J. Cancer (2010)

Kaplan–Meier plot of survival of oesophago-gastric cancer patients according to plasma MIC-1 concentration. Patients with MIC-1 concentrations in the upper quartile showed worsened survival (median 204 days; 95% CI 157–251) when compared with patients with MIC-1 concentrations in the lower three quartiles (median 316 days; 95% CI 259–373; P=0.036, log-rank test).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2837566&req=5

fig7: Kaplan–Meier plot of survival of oesophago-gastric cancer patients according to plasma MIC-1 concentration. Patients with MIC-1 concentrations in the upper quartile showed worsened survival (median 204 days; 95% CI 157–251) when compared with patients with MIC-1 concentrations in the lower three quartiles (median 316 days; 95% CI 259–373; P=0.036, log-rank test).
Mentions: Patients with plasma MIC-1 concentrations in the upper quartile (>2270 pg ml–1) showed worsened survival (median 204 days; 95% CI 157–251) when compared with patients with MIC-1 concentrations in the lower three quartiles (median 316 days; 95% CI 259–373; P=0.036; log-rank test; Figure 7). In Cox's proportional hazards model (incorporating MIC-1, CRP, percentage weight loss, disease stage, tumour grade, patient age, dysphagia score, diet score, and treatment regimen), disease stage (P<0.001), treatment regimen (P=0.003), CRP (P=0.034), and percentage weight loss (P=0.002), but not plasma MIC-1 concentration, were significant determinants of survival (Table 4). Substitution of mGPS for CRP within the model revealed stage, treatment regimen, and weight loss as the only significant determinants.

Bottom Line: However, although MIC-1 correlated weakly with dietary intake (r(2)=0.157; P=0.031), it did not correlate with weight loss, BMI, or anthropometry.Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259-373; P=0.036), but MIC-1 was not an independent prognostic indicator.There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

View Article: PubMed Central - PubMed

Affiliation: University of Edinburgh, Royal Infirmary of Edinburgh, UK.

ABSTRACT

Background: Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).

Methods: Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of > or =10 mg l(-1) or modified Glasgow prognostic score (mGPS) of > or =1), and nutritional status were assessed in newly diagnosed OGC patients (n=293). Healthy volunteers (n=35) served as controls.

Results: MIC-1 was elevated in patients (median=1371 pg ml(-1); range 141-39 053) when compared with controls (median=377 pg ml(-1); range 141-3786; P<0.001). Patients with gastric tumours (median=1592 pg ml(-1); range 141-12 643) showed higher MIC-1 concentrations than patients with junctional (median=1337 pg ml(-1); range 383-39 053) and oesophageal tumours (median=1180 pg ml(-1); range 258-31 184; P=0.015). Patients showed a median weight loss of 6.4% (range 0.0-33.4%), and 42% of patients had an mGPS of > or =1 or plasma CRP of > or =10 mg l(-1) (median=9 mg l(-1); range 1-200). MIC-1 correlated positively with disease stage (r(2)=0.217; P<0.001), age (r(2)=0.332; P<0.001), CRP (r(2)=0.314; P<0.001), and mGPS (r(2)=0.336; P<0.001), and negatively with Karnofsky Performance Score (r(2)=-0.269; P<0.001). However, although MIC-1 correlated weakly with dietary intake (r(2)=0.157; P=0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259-373; P=0.036), but MIC-1 was not an independent prognostic indicator.

Conclusions: There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

Show MeSH
Related in: MedlinePlus