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Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer.

Skipworth RJ, Deans DA, Tan BH, Sangster K, Paterson-Brown S, Brown DA, Hunter M, Breit SN, Ross JA, Fearon KC - Br. J. Cancer (2010)

Bottom Line: However, although MIC-1 correlated weakly with dietary intake (r(2)=0.157; P=0.031), it did not correlate with weight loss, BMI, or anthropometry.Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259-373; P=0.036), but MIC-1 was not an independent prognostic indicator.There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

View Article: PubMed Central - PubMed

Affiliation: University of Edinburgh, Royal Infirmary of Edinburgh, UK.

ABSTRACT

Background: Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).

Methods: Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of > or =10 mg l(-1) or modified Glasgow prognostic score (mGPS) of > or =1), and nutritional status were assessed in newly diagnosed OGC patients (n=293). Healthy volunteers (n=35) served as controls.

Results: MIC-1 was elevated in patients (median=1371 pg ml(-1); range 141-39 053) when compared with controls (median=377 pg ml(-1); range 141-3786; P<0.001). Patients with gastric tumours (median=1592 pg ml(-1); range 141-12 643) showed higher MIC-1 concentrations than patients with junctional (median=1337 pg ml(-1); range 383-39 053) and oesophageal tumours (median=1180 pg ml(-1); range 258-31 184; P=0.015). Patients showed a median weight loss of 6.4% (range 0.0-33.4%), and 42% of patients had an mGPS of > or =1 or plasma CRP of > or =10 mg l(-1) (median=9 mg l(-1); range 1-200). MIC-1 correlated positively with disease stage (r(2)=0.217; P<0.001), age (r(2)=0.332; P<0.001), CRP (r(2)=0.314; P<0.001), and mGPS (r(2)=0.336; P<0.001), and negatively with Karnofsky Performance Score (r(2)=-0.269; P<0.001). However, although MIC-1 correlated weakly with dietary intake (r(2)=0.157; P=0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259-373; P=0.036), but MIC-1 was not an independent prognostic indicator.

Conclusions: There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

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Related in: MedlinePlus

Box plot showing increasing plasma MIC-1 concentration with worsening disease stage (P=0.002).
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fig4: Box plot showing increasing plasma MIC-1 concentration with worsening disease stage (P=0.002).

Mentions: Plasma MIC-1 was elevated in OGC patients (median 1371 pg ml–1; range 141–39 053) when compared with controls (median 377 pg ml–1; range 141–3786; P<0.001; Figure 1). Patients with gastric tumours (median 1592 pg ml–1; range 141–12 643) showed higher MIC-1 concentrations than patients with oesophago-gastric junction (OGJ; median 1337 pg ml–1; range 383–39 053) and oesophageal tumours (median 1180 pg ml–1; range 258–31 184; P=0.015; Figure 2). Patients with poorly differentiated tumours (median 1480 pg ml–1; range 245–9000) showed higher MIC-1 concentrations than patients with moderately differentiated (median 1103 pg ml–1; range 378–6646) and well-differentiated tumours (median 875 pg ml–1; range 710–1407; P=0.010; Figure 3). Plasma MIC-1 concentration also increased with worsening disease stage (Figure 4) and increasing mGPS (Figure 5).


Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer.

Skipworth RJ, Deans DA, Tan BH, Sangster K, Paterson-Brown S, Brown DA, Hunter M, Breit SN, Ross JA, Fearon KC - Br. J. Cancer (2010)

Box plot showing increasing plasma MIC-1 concentration with worsening disease stage (P=0.002).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2837566&req=5

fig4: Box plot showing increasing plasma MIC-1 concentration with worsening disease stage (P=0.002).
Mentions: Plasma MIC-1 was elevated in OGC patients (median 1371 pg ml–1; range 141–39 053) when compared with controls (median 377 pg ml–1; range 141–3786; P<0.001; Figure 1). Patients with gastric tumours (median 1592 pg ml–1; range 141–12 643) showed higher MIC-1 concentrations than patients with oesophago-gastric junction (OGJ; median 1337 pg ml–1; range 383–39 053) and oesophageal tumours (median 1180 pg ml–1; range 258–31 184; P=0.015; Figure 2). Patients with poorly differentiated tumours (median 1480 pg ml–1; range 245–9000) showed higher MIC-1 concentrations than patients with moderately differentiated (median 1103 pg ml–1; range 378–6646) and well-differentiated tumours (median 875 pg ml–1; range 710–1407; P=0.010; Figure 3). Plasma MIC-1 concentration also increased with worsening disease stage (Figure 4) and increasing mGPS (Figure 5).

Bottom Line: However, although MIC-1 correlated weakly with dietary intake (r(2)=0.157; P=0.031), it did not correlate with weight loss, BMI, or anthropometry.Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259-373; P=0.036), but MIC-1 was not an independent prognostic indicator.There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

View Article: PubMed Central - PubMed

Affiliation: University of Edinburgh, Royal Infirmary of Edinburgh, UK.

ABSTRACT

Background: Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC).

Methods: Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of > or =10 mg l(-1) or modified Glasgow prognostic score (mGPS) of > or =1), and nutritional status were assessed in newly diagnosed OGC patients (n=293). Healthy volunteers (n=35) served as controls.

Results: MIC-1 was elevated in patients (median=1371 pg ml(-1); range 141-39 053) when compared with controls (median=377 pg ml(-1); range 141-3786; P<0.001). Patients with gastric tumours (median=1592 pg ml(-1); range 141-12 643) showed higher MIC-1 concentrations than patients with junctional (median=1337 pg ml(-1); range 383-39 053) and oesophageal tumours (median=1180 pg ml(-1); range 258-31 184; P=0.015). Patients showed a median weight loss of 6.4% (range 0.0-33.4%), and 42% of patients had an mGPS of > or =1 or plasma CRP of > or =10 mg l(-1) (median=9 mg l(-1); range 1-200). MIC-1 correlated positively with disease stage (r(2)=0.217; P<0.001), age (r(2)=0.332; P<0.001), CRP (r(2)=0.314; P<0.001), and mGPS (r(2)=0.336; P<0.001), and negatively with Karnofsky Performance Score (r(2)=-0.269; P<0.001). However, although MIC-1 correlated weakly with dietary intake (r(2)=0.157; P=0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median=204 days; 95% CI 157-251) when compared with patients with MIC-1 levels in the lower three quartiles (median=316 days; 95% CI 259-373; P=0.036), but MIC-1 was not an independent prognostic indicator.

Conclusions: There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

Show MeSH
Related in: MedlinePlus