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Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature.

Kuyama K, Fifita SF, Komiya M, Sun Y, Akimoto Y, Yamamoto H - Int J Dent (2009)

Bottom Line: Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied.These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively.These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan.

ABSTRACT
The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 alpha & beta and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

No MeSH data available.


Related in: MedlinePlus

Case 2. Fibrolipoma with osseous/chondroid differentiation. Mature fat cells are supported by fibrous connective tissue with myxoid change and cartilage nodule associated with trabecular bone tissue in it (HE, original magnification ×40).
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fig2: Case 2. Fibrolipoma with osseous/chondroid differentiation. Mature fat cells are supported by fibrous connective tissue with myxoid change and cartilage nodule associated with trabecular bone tissue in it (HE, original magnification ×40).

Mentions: A 59-year-old man presented with a relatively painless hard mass on the left side of the lower labial vestibule surface, which appeared the sense of incompatibility 2 months prior to consultation. Examination showed a well- defined hard nodular mass, approximately 5 mm in diameter, and freely mobile, and covered with mucosa of normal aspect and color. There was no tenderness, no sign of inflammation. To retrieve more-detailed relativity with the surrounding tissue, CT was taken and showed a lesion in the left side of the lower lip that appeared to be a small mass with areas of little calcification within. This lesion was surgically excised with the clinical diagnosis of fibroma with calcification. Gross examination showed a yellowish soft to hard smooth mass measuring 9 × 5× 5 mm in size. Microscopically, the tumor consisted of a well-circumscribed mass of mature fat cells supported by fibrous connective tissue septa and myxoid tissue characterized by spindle cells. A focal island of consecutive chondroid and woven bone component was surrounded by spindle/fusiform-shaped mesenchymal cells throughout the lesion (Figure 2). Pathological diagnosis was made as fibrolipoma with osseous/chondroid differentiation.


Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature.

Kuyama K, Fifita SF, Komiya M, Sun Y, Akimoto Y, Yamamoto H - Int J Dent (2009)

Case 2. Fibrolipoma with osseous/chondroid differentiation. Mature fat cells are supported by fibrous connective tissue with myxoid change and cartilage nodule associated with trabecular bone tissue in it (HE, original magnification ×40).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2837472&req=5

fig2: Case 2. Fibrolipoma with osseous/chondroid differentiation. Mature fat cells are supported by fibrous connective tissue with myxoid change and cartilage nodule associated with trabecular bone tissue in it (HE, original magnification ×40).
Mentions: A 59-year-old man presented with a relatively painless hard mass on the left side of the lower labial vestibule surface, which appeared the sense of incompatibility 2 months prior to consultation. Examination showed a well- defined hard nodular mass, approximately 5 mm in diameter, and freely mobile, and covered with mucosa of normal aspect and color. There was no tenderness, no sign of inflammation. To retrieve more-detailed relativity with the surrounding tissue, CT was taken and showed a lesion in the left side of the lower lip that appeared to be a small mass with areas of little calcification within. This lesion was surgically excised with the clinical diagnosis of fibroma with calcification. Gross examination showed a yellowish soft to hard smooth mass measuring 9 × 5× 5 mm in size. Microscopically, the tumor consisted of a well-circumscribed mass of mature fat cells supported by fibrous connective tissue septa and myxoid tissue characterized by spindle cells. A focal island of consecutive chondroid and woven bone component was surrounded by spindle/fusiform-shaped mesenchymal cells throughout the lesion (Figure 2). Pathological diagnosis was made as fibrolipoma with osseous/chondroid differentiation.

Bottom Line: Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied.These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively.These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan.

ABSTRACT
The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 alpha & beta and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

No MeSH data available.


Related in: MedlinePlus