Limits...
Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature.

Kuyama K, Fifita SF, Komiya M, Sun Y, Akimoto Y, Yamamoto H - Int J Dent (2009)

Bottom Line: Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied.These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively.These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan.

ABSTRACT
The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 alpha & beta and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

No MeSH data available.


Related in: MedlinePlus

Case 1. Lipoma with chondroid differentiation. Area of mature cartilage nodule is surrounded by normal adipose tissue (HE, original magnification ×40).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2837472&req=5

fig1: Case 1. Lipoma with chondroid differentiation. Area of mature cartilage nodule is surrounded by normal adipose tissue (HE, original magnification ×40).

Mentions: A 28-year-old woman presented with a painless relatively hard mass on the dorsal surface in the midline of the tongue that had recently grew slightly. The patient's mother first noticed a tiny nodule when the patient was 6 months old. The lesion had been left because there was no subjective symptom. Examination showed a well-defined hard nodular mass, approximately 16 × 16 × 9 mm in size, which was sharply demarcated within the muscles of the tongue and freely mobile. A yellowish tinge was visible through the overlying mucous membrane and the lesion was firm on palpation. Clinical diagnosis of lipoma with calculus was made and the tumor was completely excised from the tongue under general anesthesia. Gross examination showed a yellowish soft to hard smooth mass measuring 16 × 15 × 12 mm in size. Microscopically, the tumor consisted of a well-circumscribed mass of fatty tissue with a cellular chondroid component. Chondromatous nodules within uniform adipose tissue were seen in large areas of mature fat cells supported by fibrous connective tissue (Figure 1). Pathological diagnosis was made as lipoma with chondroid differentiation.


Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature.

Kuyama K, Fifita SF, Komiya M, Sun Y, Akimoto Y, Yamamoto H - Int J Dent (2009)

Case 1. Lipoma with chondroid differentiation. Area of mature cartilage nodule is surrounded by normal adipose tissue (HE, original magnification ×40).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2837472&req=5

fig1: Case 1. Lipoma with chondroid differentiation. Area of mature cartilage nodule is surrounded by normal adipose tissue (HE, original magnification ×40).
Mentions: A 28-year-old woman presented with a painless relatively hard mass on the dorsal surface in the midline of the tongue that had recently grew slightly. The patient's mother first noticed a tiny nodule when the patient was 6 months old. The lesion had been left because there was no subjective symptom. Examination showed a well-defined hard nodular mass, approximately 16 × 16 × 9 mm in size, which was sharply demarcated within the muscles of the tongue and freely mobile. A yellowish tinge was visible through the overlying mucous membrane and the lesion was firm on palpation. Clinical diagnosis of lipoma with calculus was made and the tumor was completely excised from the tongue under general anesthesia. Gross examination showed a yellowish soft to hard smooth mass measuring 16 × 15 × 12 mm in size. Microscopically, the tumor consisted of a well-circumscribed mass of fatty tissue with a cellular chondroid component. Chondromatous nodules within uniform adipose tissue were seen in large areas of mature fat cells supported by fibrous connective tissue (Figure 1). Pathological diagnosis was made as lipoma with chondroid differentiation.

Bottom Line: Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied.These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively.These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan.

ABSTRACT
The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 alpha & beta and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

No MeSH data available.


Related in: MedlinePlus