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Clinical, molecular and geographical features of hereditary breast/ovarian cancer in latvia.

Gardovskis A, Irmejs A, Miklasevics E, Borosenko V, Bitina M, Melbarde-Gorkusa I, Vanags A, Kurzawski G, Suchy J, Górski B, Gardovskis J - Hered Cancer Clin Pract (2005)

Bottom Line: Existing pedigree/clinical data suggest that in Latvia the clinical frequency of hereditary breast and ovarian cancer is around 5% of consecutive breast and ovarian cancer patients and suspicion of the syndrome is observed in another 20% of cases.Frequency of BRCA1 founder mutations is 5% of all consecutive breast and ovarian cancers.Considerable geographical differences in the clinical and molecular frequency of hereditary breast ovarian cancer have been observed in Latvia.

View Article: PubMed Central - HTML - PubMed

Affiliation: Hereditary Cancer Institute, Riga Stradins University, Latvia. hci@stradini.lv.

ABSTRACT

Introduction: The aim of the study is to evaluate the incidence and phenotype-genotype characteristics of hereditary breast and ovarian cancer syndromes in Latvia in order to develop the basis of clinical management for patients and their relatives affected by this syndrome.

Materials and methods: In 2002-2004 in two Latvian oncology hospitals (Liepãja Oncology Hospital and Daugavpils Oncology Hospital) cancer family histories were collected from 287 consecutive patients with breast and ovarian cancer. In all cases, when it was possible to obtain the blood sample, DNA testing for founder mutations in the BRCA1 gene was performed.

Results: Among 287 family cancer histories analysed in 8 (2.8%) cases criteria of hereditary breast cancer (HBC) were fulfilled and in 5 (1.7%) cases hereditary breast and ovarian cancer (HBOC) was diagnosed. In 50 (17.4%) cases we have suspicion of hereditary breast cancer (HBC susp.) and in 8 (2.8%) cases - suspicion of hereditary breast and ovarian cancer (HBOC susp.). We have one (0.3%) case with hereditary ovarian cancer (HOC). DNA testing of founder mutations in the BRCA1 gene (exon 20 (5382 insC) exon 5 (300T/G), exon 11, 17 (4153delA)) for 178/287 (62%) patients was performed. In 9/287 (4.9%) cases we found a mutation in the BRCA1 gene. 4 mutations were detected in exon 11, 17 (4153delA) and 4 mutations in exon 20 (5382 insC) and 1 in exon 5.

Conclusions: Existing pedigree/clinical data suggest that in Latvia the clinical frequency of hereditary breast and ovarian cancer is around 5% of consecutive breast and ovarian cancer patients and suspicion of the syndrome is observed in another 20% of cases. Frequency of BRCA1 founder mutations is 5% of all consecutive breast and ovarian cancers. Considerable geographical differences in the clinical and molecular frequency of hereditary breast ovarian cancer have been observed in Latvia.

No MeSH data available.


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Geographical map of Latvia.
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Figure 1: Geographical map of Latvia.

Mentions: However the most interesting finding is considerable differences of features of hereditary breast/ovarian cancer between two historically, geographically and ethnically different regions of Latvia, the region of Liepãja and that of Daugavpils. The distance between those two regions is approximately 500 km. A map of Latvia with both regions marked is presented in Fig. 1. For ethnic differences in the regions of Liepãja and Daugavpils see Table 5. Among 287 family cancer histories analysed, 128 cases come from the Oncology Hospital of Daugavpils and 159 cases from the Oncology Hospital of Liepãja. From all 8 (2.8%) cases of hereditary breast cancer (HBC), 7 cases come from the Oncology Hospital of Daugavpils and only one case from the Oncology Hospital of Liepãja. Among hereditary breast and ovarian cancer cases (HBOC) all 5 (1.7%) cases come from the Oncology Hospital of Daugavpils. 8 BRCA1 founder mutations were detected in the region of Daugavpils and only one in the region of Liepãja, resulting in BRCA1 founder mutation frequency in consecutive breast and ovarian cancers of 6.3% and 0.6%, respectively. Table 6 presents a comparison of clinical and molecular results between regions of Liepãja and Daugavpils.


Clinical, molecular and geographical features of hereditary breast/ovarian cancer in latvia.

Gardovskis A, Irmejs A, Miklasevics E, Borosenko V, Bitina M, Melbarde-Gorkusa I, Vanags A, Kurzawski G, Suchy J, Górski B, Gardovskis J - Hered Cancer Clin Pract (2005)

Geographical map of Latvia.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2837301&req=5

Figure 1: Geographical map of Latvia.
Mentions: However the most interesting finding is considerable differences of features of hereditary breast/ovarian cancer between two historically, geographically and ethnically different regions of Latvia, the region of Liepãja and that of Daugavpils. The distance between those two regions is approximately 500 km. A map of Latvia with both regions marked is presented in Fig. 1. For ethnic differences in the regions of Liepãja and Daugavpils see Table 5. Among 287 family cancer histories analysed, 128 cases come from the Oncology Hospital of Daugavpils and 159 cases from the Oncology Hospital of Liepãja. From all 8 (2.8%) cases of hereditary breast cancer (HBC), 7 cases come from the Oncology Hospital of Daugavpils and only one case from the Oncology Hospital of Liepãja. Among hereditary breast and ovarian cancer cases (HBOC) all 5 (1.7%) cases come from the Oncology Hospital of Daugavpils. 8 BRCA1 founder mutations were detected in the region of Daugavpils and only one in the region of Liepãja, resulting in BRCA1 founder mutation frequency in consecutive breast and ovarian cancers of 6.3% and 0.6%, respectively. Table 6 presents a comparison of clinical and molecular results between regions of Liepãja and Daugavpils.

Bottom Line: Existing pedigree/clinical data suggest that in Latvia the clinical frequency of hereditary breast and ovarian cancer is around 5% of consecutive breast and ovarian cancer patients and suspicion of the syndrome is observed in another 20% of cases.Frequency of BRCA1 founder mutations is 5% of all consecutive breast and ovarian cancers.Considerable geographical differences in the clinical and molecular frequency of hereditary breast ovarian cancer have been observed in Latvia.

View Article: PubMed Central - HTML - PubMed

Affiliation: Hereditary Cancer Institute, Riga Stradins University, Latvia. hci@stradini.lv.

ABSTRACT

Introduction: The aim of the study is to evaluate the incidence and phenotype-genotype characteristics of hereditary breast and ovarian cancer syndromes in Latvia in order to develop the basis of clinical management for patients and their relatives affected by this syndrome.

Materials and methods: In 2002-2004 in two Latvian oncology hospitals (Liepãja Oncology Hospital and Daugavpils Oncology Hospital) cancer family histories were collected from 287 consecutive patients with breast and ovarian cancer. In all cases, when it was possible to obtain the blood sample, DNA testing for founder mutations in the BRCA1 gene was performed.

Results: Among 287 family cancer histories analysed in 8 (2.8%) cases criteria of hereditary breast cancer (HBC) were fulfilled and in 5 (1.7%) cases hereditary breast and ovarian cancer (HBOC) was diagnosed. In 50 (17.4%) cases we have suspicion of hereditary breast cancer (HBC susp.) and in 8 (2.8%) cases - suspicion of hereditary breast and ovarian cancer (HBOC susp.). We have one (0.3%) case with hereditary ovarian cancer (HOC). DNA testing of founder mutations in the BRCA1 gene (exon 20 (5382 insC) exon 5 (300T/G), exon 11, 17 (4153delA)) for 178/287 (62%) patients was performed. In 9/287 (4.9%) cases we found a mutation in the BRCA1 gene. 4 mutations were detected in exon 11, 17 (4153delA) and 4 mutations in exon 20 (5382 insC) and 1 in exon 5.

Conclusions: Existing pedigree/clinical data suggest that in Latvia the clinical frequency of hereditary breast and ovarian cancer is around 5% of consecutive breast and ovarian cancer patients and suspicion of the syndrome is observed in another 20% of cases. Frequency of BRCA1 founder mutations is 5% of all consecutive breast and ovarian cancers. Considerable geographical differences in the clinical and molecular frequency of hereditary breast ovarian cancer have been observed in Latvia.

No MeSH data available.


Related in: MedlinePlus