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Morphological changes of gingiva in streptozotocin diabetic rats.

Tesseromatis C, Kotsiou A, Parara H, Vairaktaris E, Tsamouri M - Int J Dent (2009)

Bottom Line: The histological investigation of the marginal gingival and the relevant gingival papilla showed inflammation of the lamina propria and the squamous epithelium as well as marked thickness of the arteriole in the diabetic group, but no changes were observed in the control group.The results suggested a probable application of a routine gingival histological investigation in diabetic patients in order to control the progress of disease complications.It may be concluded that histological gingival investigation can be used as a routine assay for the control of the diabetic disease and prevention of its complications.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Medical School, University of Athens, Mikras Assias 75, 11527 Goudi, Greece.

ABSTRACT
Gingivitis and periodontitis are chronic bacterial diseases of the underlying and surrounding tooth tissues. Diabetes mellitus is responsible for tooth deprivation both by decay and periodontal disease. The streptozotocin-induced diabetes results in a diabetic status in experimental animals similar to that observed in diabetes patients. The aim of the study was to investigate the relationship between the gingival lesions and the microangiopathy changes in streptozotocin-induced diabetes mellitus. Forty male Wistar rats were divided into two groups (control and experimental). Diabetes mellitus was induced by 45 mg/kg IV streptozotocin. The histological investigation of the marginal gingival and the relevant gingival papilla showed inflammation of the lamina propria and the squamous epithelium as well as marked thickness of the arteriole in the diabetic group, but no changes were observed in the control group. The results suggested a probable application of a routine gingival histological investigation in diabetic patients in order to control the progress of disease complications. It may be concluded that histological gingival investigation can be used as a routine assay for the control of the diabetic disease and prevention of its complications.

No MeSH data available.


Related in: MedlinePlus

(∗) Hyperplasia of the squamousepithelium,  (▴) diffuse and perivascular inflammation of the lamina propria, and (↑) thickening of the wall of some arterioles.
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fig2: (∗) Hyperplasia of the squamousepithelium, (▴) diffuse and perivascular inflammation of the lamina propria, and (↑) thickening of the wall of some arterioles.

Mentions: The gingival specimens obtained fromthe molar area of the mandible of the buccal and lingual sites showed moderate tohigh hyperceratosis and mild inflammation. All the experimental animals showedmoderate-to-severe angiitis, which was not observed in the control animals (seeTable 2, Figures 1 and 2).


Morphological changes of gingiva in streptozotocin diabetic rats.

Tesseromatis C, Kotsiou A, Parara H, Vairaktaris E, Tsamouri M - Int J Dent (2009)

(∗) Hyperplasia of the squamousepithelium,  (▴) diffuse and perivascular inflammation of the lamina propria, and (↑) thickening of the wall of some arterioles.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2836915&req=5

fig2: (∗) Hyperplasia of the squamousepithelium, (▴) diffuse and perivascular inflammation of the lamina propria, and (↑) thickening of the wall of some arterioles.
Mentions: The gingival specimens obtained fromthe molar area of the mandible of the buccal and lingual sites showed moderate tohigh hyperceratosis and mild inflammation. All the experimental animals showedmoderate-to-severe angiitis, which was not observed in the control animals (seeTable 2, Figures 1 and 2).

Bottom Line: The histological investigation of the marginal gingival and the relevant gingival papilla showed inflammation of the lamina propria and the squamous epithelium as well as marked thickness of the arteriole in the diabetic group, but no changes were observed in the control group.The results suggested a probable application of a routine gingival histological investigation in diabetic patients in order to control the progress of disease complications.It may be concluded that histological gingival investigation can be used as a routine assay for the control of the diabetic disease and prevention of its complications.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Medical School, University of Athens, Mikras Assias 75, 11527 Goudi, Greece.

ABSTRACT
Gingivitis and periodontitis are chronic bacterial diseases of the underlying and surrounding tooth tissues. Diabetes mellitus is responsible for tooth deprivation both by decay and periodontal disease. The streptozotocin-induced diabetes results in a diabetic status in experimental animals similar to that observed in diabetes patients. The aim of the study was to investigate the relationship between the gingival lesions and the microangiopathy changes in streptozotocin-induced diabetes mellitus. Forty male Wistar rats were divided into two groups (control and experimental). Diabetes mellitus was induced by 45 mg/kg IV streptozotocin. The histological investigation of the marginal gingival and the relevant gingival papilla showed inflammation of the lamina propria and the squamous epithelium as well as marked thickness of the arteriole in the diabetic group, but no changes were observed in the control group. The results suggested a probable application of a routine gingival histological investigation in diabetic patients in order to control the progress of disease complications. It may be concluded that histological gingival investigation can be used as a routine assay for the control of the diabetic disease and prevention of its complications.

No MeSH data available.


Related in: MedlinePlus