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The spectrum of fundus autofluorescence findings in birdshot chorioretinopathy.

Giuliari G, Hinkle DM, Foster CS - J Ophthalmol (2010)

Bottom Line: Results.Conclusion.Because FAF testing provides valuable insight into the metabolic state of the PR/RPE-complex, it may serve as a useful noninvasive assessment tool in patients with posterior uveitis in which the outer retina-RPE-choriocapillaries-complex is involved.

View Article: PubMed Central - PubMed

Affiliation: Massachusetts Eye Research and Surgery Institution, Cambridge, MA 02142, USA.

ABSTRACT
Objective. To describe the diverse patterns observed with the use of autofluorescence fundus photography (FAF) in patients with Birdshot chorioretinopathy (BSCR). Methods. A chart review of patients with BSCR seen at the Massachusetts Eye Research and Surgery Institution, who had autofluorescence fundus photography. The data obtained included age, gender, presence of the HLA-A29 haplotype, and current treatment. Results. Eighteen eyes with HLA-A29 associated BSCR were included. Four eyes presented with active inflammation. Correspondence of the lesions noted in the colour fundus photograph was observed in 3 eyes which were more easily identified with the FAF. Fifteen eyes had fundus lesions more numerous and evident in the FAF than in the colour fundus photograph. Conclusion. Because FAF testing provides valuable insight into the metabolic state of the PR/RPE-complex, it may serve as a useful noninvasive assessment tool in patients with posterior uveitis in which the outer retina-RPE-choriocapillaries-complex is involved.

No MeSH data available.


Related in: MedlinePlus

Images from the left eye of a 58-year-old woman with birdshot chorioretinopathy (patient 5). (a) Fundus colour photograph shows poorly pigmented fundus with scatter BSCR lesions nasal to the optic nerve. (b) Autofluorescence photograph shows scattered areas of RPE atrophy as hypoautofluorescent spots and as a linear pattern along the retinal vessels.
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fig2: Images from the left eye of a 58-year-old woman with birdshot chorioretinopathy (patient 5). (a) Fundus colour photograph shows poorly pigmented fundus with scatter BSCR lesions nasal to the optic nerve. (b) Autofluorescence photograph shows scattered areas of RPE atrophy as hypoautofluorescent spots and as a linear pattern along the retinal vessels.

Mentions: Four (22%) eyes presented with active inflammation characterized by optic nerve leaking and/or retinal vasculitis assessed by FA. Three (17%) eyes presented with macular oedema confirmed both by FA and OCT. None of the eyes with macular oedema showed macular hypoautofluorescence. Full correspondence of the lesions noted in the colour fundus photograph was observed in 3 (17%) eyes of 2 patients; however, they were more easily identified with the FAF. In 15 eyes (83%), fundus lesions were more numerous and more easily identified in the FAF than in the colour fundus photograph. These fundi had the typical BSCR lesions, peripapillary chorioretinal atrophy characterized as a circumferential hypoautofluorescence around the optic nerve, and in 3 (17%) eyes a linear hypoautofluorescence pattern along the retinal vessels was noted (Figures 1 and 2).


The spectrum of fundus autofluorescence findings in birdshot chorioretinopathy.

Giuliari G, Hinkle DM, Foster CS - J Ophthalmol (2010)

Images from the left eye of a 58-year-old woman with birdshot chorioretinopathy (patient 5). (a) Fundus colour photograph shows poorly pigmented fundus with scatter BSCR lesions nasal to the optic nerve. (b) Autofluorescence photograph shows scattered areas of RPE atrophy as hypoautofluorescent spots and as a linear pattern along the retinal vessels.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2836822&req=5

fig2: Images from the left eye of a 58-year-old woman with birdshot chorioretinopathy (patient 5). (a) Fundus colour photograph shows poorly pigmented fundus with scatter BSCR lesions nasal to the optic nerve. (b) Autofluorescence photograph shows scattered areas of RPE atrophy as hypoautofluorescent spots and as a linear pattern along the retinal vessels.
Mentions: Four (22%) eyes presented with active inflammation characterized by optic nerve leaking and/or retinal vasculitis assessed by FA. Three (17%) eyes presented with macular oedema confirmed both by FA and OCT. None of the eyes with macular oedema showed macular hypoautofluorescence. Full correspondence of the lesions noted in the colour fundus photograph was observed in 3 (17%) eyes of 2 patients; however, they were more easily identified with the FAF. In 15 eyes (83%), fundus lesions were more numerous and more easily identified in the FAF than in the colour fundus photograph. These fundi had the typical BSCR lesions, peripapillary chorioretinal atrophy characterized as a circumferential hypoautofluorescence around the optic nerve, and in 3 (17%) eyes a linear hypoautofluorescence pattern along the retinal vessels was noted (Figures 1 and 2).

Bottom Line: Results.Conclusion.Because FAF testing provides valuable insight into the metabolic state of the PR/RPE-complex, it may serve as a useful noninvasive assessment tool in patients with posterior uveitis in which the outer retina-RPE-choriocapillaries-complex is involved.

View Article: PubMed Central - PubMed

Affiliation: Massachusetts Eye Research and Surgery Institution, Cambridge, MA 02142, USA.

ABSTRACT
Objective. To describe the diverse patterns observed with the use of autofluorescence fundus photography (FAF) in patients with Birdshot chorioretinopathy (BSCR). Methods. A chart review of patients with BSCR seen at the Massachusetts Eye Research and Surgery Institution, who had autofluorescence fundus photography. The data obtained included age, gender, presence of the HLA-A29 haplotype, and current treatment. Results. Eighteen eyes with HLA-A29 associated BSCR were included. Four eyes presented with active inflammation. Correspondence of the lesions noted in the colour fundus photograph was observed in 3 eyes which were more easily identified with the FAF. Fifteen eyes had fundus lesions more numerous and evident in the FAF than in the colour fundus photograph. Conclusion. Because FAF testing provides valuable insight into the metabolic state of the PR/RPE-complex, it may serve as a useful noninvasive assessment tool in patients with posterior uveitis in which the outer retina-RPE-choriocapillaries-complex is involved.

No MeSH data available.


Related in: MedlinePlus