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Where the wild things are: pathogenesis of SIV infection in African nonhuman primate hosts.

Pandrea I, Apetrei C - Curr HIV/AIDS Rep (2010)

Bottom Line: African nonhuman primates that are natural hosts of simian immunodeficiency virus (SIV) are generally spared from disease progression.Pathogenic and nonpathogenic SIV infections share some major features: high viral replication, massive acute depletion of mucosal CD4(+) T cells, and partial control of the virus by both adaptive and innate immune responses.A key distinction of natural SIV infections is rapid and active control of immune activation and apoptosis of T cells that contributes to the integrity of mucosal barrier and lack of microbial translocation.

View Article: PubMed Central - PubMed

Affiliation: Center for Vaccine Research and Department of Pathology, University of Pittsburgh, 9014 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA, 15261-9045, USA. pandrea@cvr.pitt.edu

ABSTRACT
African nonhuman primates that are natural hosts of simian immunodeficiency virus (SIV) are generally spared from disease progression. Pathogenic and nonpathogenic SIV infections share some major features: high viral replication, massive acute depletion of mucosal CD4(+) T cells, and partial control of the virus by both adaptive and innate immune responses. A key distinction of natural SIV infections is rapid and active control of immune activation and apoptosis of T cells that contributes to the integrity of mucosal barrier and lack of microbial translocation. This allows partial recovery of CD4(+) T cells and preservation of the function of other immune cell subsets. A better understanding of the mechanisms underlying the lack of disease in natural hosts for SIV infection will likely provide important clues as to the therapy of HIV-1 infection.

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Related in: MedlinePlus

Several mechanisms are involved in the control of immune activation in natural hosts of simian immunodeficiency viruses. In turn, normal levels of immune activation may result in prevention of disease progression through several pathways. pDCs plasmacytoid dendritic cells; TLR Toll-like receptor
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Fig1: Several mechanisms are involved in the control of immune activation in natural hosts of simian immunodeficiency viruses. In turn, normal levels of immune activation may result in prevention of disease progression through several pathways. pDCs plasmacytoid dendritic cells; TLR Toll-like receptor

Mentions: Multiple mechanisms may be responsible for the lack of immune activation in the natural host (Fig. 1):Fig. 1


Where the wild things are: pathogenesis of SIV infection in African nonhuman primate hosts.

Pandrea I, Apetrei C - Curr HIV/AIDS Rep (2010)

Several mechanisms are involved in the control of immune activation in natural hosts of simian immunodeficiency viruses. In turn, normal levels of immune activation may result in prevention of disease progression through several pathways. pDCs plasmacytoid dendritic cells; TLR Toll-like receptor
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2824118&req=5

Fig1: Several mechanisms are involved in the control of immune activation in natural hosts of simian immunodeficiency viruses. In turn, normal levels of immune activation may result in prevention of disease progression through several pathways. pDCs plasmacytoid dendritic cells; TLR Toll-like receptor
Mentions: Multiple mechanisms may be responsible for the lack of immune activation in the natural host (Fig. 1):Fig. 1

Bottom Line: African nonhuman primates that are natural hosts of simian immunodeficiency virus (SIV) are generally spared from disease progression.Pathogenic and nonpathogenic SIV infections share some major features: high viral replication, massive acute depletion of mucosal CD4(+) T cells, and partial control of the virus by both adaptive and innate immune responses.A key distinction of natural SIV infections is rapid and active control of immune activation and apoptosis of T cells that contributes to the integrity of mucosal barrier and lack of microbial translocation.

View Article: PubMed Central - PubMed

Affiliation: Center for Vaccine Research and Department of Pathology, University of Pittsburgh, 9014 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA, 15261-9045, USA. pandrea@cvr.pitt.edu

ABSTRACT
African nonhuman primates that are natural hosts of simian immunodeficiency virus (SIV) are generally spared from disease progression. Pathogenic and nonpathogenic SIV infections share some major features: high viral replication, massive acute depletion of mucosal CD4(+) T cells, and partial control of the virus by both adaptive and innate immune responses. A key distinction of natural SIV infections is rapid and active control of immune activation and apoptosis of T cells that contributes to the integrity of mucosal barrier and lack of microbial translocation. This allows partial recovery of CD4(+) T cells and preservation of the function of other immune cell subsets. A better understanding of the mechanisms underlying the lack of disease in natural hosts for SIV infection will likely provide important clues as to the therapy of HIV-1 infection.

Show MeSH
Related in: MedlinePlus