Causal connectivity between the human anterior intraparietal area and premotor cortex during grasp.
Bottom Line: At rest, AIP virtual lesions did not modify PMv-M1 interactions.In contrast, the usual muscle-specific PMv-M1 interactions that appeared during grasp preparation were significantly reduced following AIP cTBS without directly modifying corticospinal excitability.Behaviorally, disruption of AIP was also associated with a relative loss of the grasp-specific pattern of digit muscle activity.
Affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. firstname.lastname@example.orgShow MeSH
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Mentions: Subjects were presented with two different objects, a pen or a disc (Figure 1B), which they had to lift with a precision grip or whole-hand grasp, respectively. The precision grip required more activity in the first dorsal interosseous (1DI) muscle than the whole-hand grasp; conversely, there was more abductor digiti minimi (ADM) muscle activity for the whole-hand grasp than the precision grip (repeated-measure analysis of variance [RM-ANOVA] grasp main effect: both F > 11.35, both p < 0.001; Figure 2B). This pattern was expected because 1DI is a prime mover in precision grip, whereas the ADM abducts the little finger to open the hand in the whole-hand grasp .
Affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. email@example.com