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The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history.

Peng Y, Shi H, Qi XB, Xiao CJ, Zhong H, Ma RL, Su B - BMC Evol. Biol. (2010)

Bottom Line: We present genetic evidence of selection on the ADH1BArg47His polymorphism caused by the emergence and expansion of rice domestication in East Asia.The geographic distribution of the ADH1B*47His allele in East Asia is consistent with the unearthed culture relic sites of rice domestication in China.The estimated origin time of ADH1B*47His allele in those populations coincides with the time of origin and expansion of Neolithic agriculture in southern China.

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Affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, Chinese Academy of Sciences, Kunming, China.

ABSTRACT

Background: The emergence of agriculture about 10,000 years ago marks a dramatic change in human evolutionary history. The diet shift in agriculture societies might have a great impact on the genetic makeup of Neolithic human populations. The regionally restricted enrichment of the class I alcohol dehydrogenase sequence polymorphism (ADH1BArg47His) in southern China and the adjacent areas suggests Darwinian positive selection on this genetic locus during Neolithic time though the driving force is yet to be disclosed.

Results: We studied a total of 38 populations (2,275 individuals) including Han Chinese, Tibetan and other ethnic populations across China. The geographic distribution of the ADH1B*47His allele in these populations indicates a clear east-to-west cline, and it is dominant in south-eastern populations but rare in Tibetan populations. The molecular dating suggests that the emergence of the ADH1B*47His allele occurred about 10,000 to approximately 7,000 years ago.

Conclusion: We present genetic evidence of selection on the ADH1BArg47His polymorphism caused by the emergence and expansion of rice domestication in East Asia. The geographic distribution of the ADH1B*47His allele in East Asia is consistent with the unearthed culture relic sites of rice domestication in China. The estimated origin time of ADH1B*47His allele in those populations coincides with the time of origin and expansion of Neolithic agriculture in southern China.

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The distribution of the ADH1B*47His allele and the sites of early rice relics. The contour map of the ADH1B*47His frequency in East Asian populations and the ancient sites of rice domestication in China. The allele frequency data includes the 38 populations in the present study and those published before.[17]. The geographic locations of the rice sites are from the published data [5].
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Figure 1: The distribution of the ADH1B*47His allele and the sites of early rice relics. The contour map of the ADH1B*47His frequency in East Asian populations and the ancient sites of rice domestication in China. The allele frequency data includes the 38 populations in the present study and those published before.[17]. The geographic locations of the rice sites are from the published data [5].

Mentions: We analyzed a total of 2,275 individuals from 38 East Asian populations, especially those not included in the previous reports (northern Han Chinese, Tibetan and southern ethnic populations in China). Table 1 lists the frequencies of ADH1B*47His in the 38 populations. In general, the distribution pattern is consistent with the previous reports[14,17], and most of the populations (31/38) have frequencies higher than 50%. In Han Chinese, the highest frequency is detected in Zhejiang province of south-eastern China (98.5%), and those in the west have relatively low frequencies (60-70%). The same pattern is also observed for the other ethnic populations from China and Southeast Asia (Cambodia and Thailand) except for Tibetan (14.1% on average), Bulang (1.7%, an ethnic population from south-western China) and Cambodian (20.6%). All the five Tibetan populations from different geographic regions have low frequencies (13-21%). We created a contour map based on the data from the 38 populations and those published before (Figure. 1). The distribution of the frequencies of ADH1B*47His confirms its prevalence in East Asia and a clear east-to-west cline is observed.


The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history.

Peng Y, Shi H, Qi XB, Xiao CJ, Zhong H, Ma RL, Su B - BMC Evol. Biol. (2010)

The distribution of the ADH1B*47His allele and the sites of early rice relics. The contour map of the ADH1B*47His frequency in East Asian populations and the ancient sites of rice domestication in China. The allele frequency data includes the 38 populations in the present study and those published before.[17]. The geographic locations of the rice sites are from the published data [5].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2823730&req=5

Figure 1: The distribution of the ADH1B*47His allele and the sites of early rice relics. The contour map of the ADH1B*47His frequency in East Asian populations and the ancient sites of rice domestication in China. The allele frequency data includes the 38 populations in the present study and those published before.[17]. The geographic locations of the rice sites are from the published data [5].
Mentions: We analyzed a total of 2,275 individuals from 38 East Asian populations, especially those not included in the previous reports (northern Han Chinese, Tibetan and southern ethnic populations in China). Table 1 lists the frequencies of ADH1B*47His in the 38 populations. In general, the distribution pattern is consistent with the previous reports[14,17], and most of the populations (31/38) have frequencies higher than 50%. In Han Chinese, the highest frequency is detected in Zhejiang province of south-eastern China (98.5%), and those in the west have relatively low frequencies (60-70%). The same pattern is also observed for the other ethnic populations from China and Southeast Asia (Cambodia and Thailand) except for Tibetan (14.1% on average), Bulang (1.7%, an ethnic population from south-western China) and Cambodian (20.6%). All the five Tibetan populations from different geographic regions have low frequencies (13-21%). We created a contour map based on the data from the 38 populations and those published before (Figure. 1). The distribution of the frequencies of ADH1B*47His confirms its prevalence in East Asia and a clear east-to-west cline is observed.

Bottom Line: We present genetic evidence of selection on the ADH1BArg47His polymorphism caused by the emergence and expansion of rice domestication in East Asia.The geographic distribution of the ADH1B*47His allele in East Asia is consistent with the unearthed culture relic sites of rice domestication in China.The estimated origin time of ADH1B*47His allele in those populations coincides with the time of origin and expansion of Neolithic agriculture in southern China.

View Article: PubMed Central - HTML - PubMed

Affiliation: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, Chinese Academy of Sciences, Kunming, China.

ABSTRACT

Background: The emergence of agriculture about 10,000 years ago marks a dramatic change in human evolutionary history. The diet shift in agriculture societies might have a great impact on the genetic makeup of Neolithic human populations. The regionally restricted enrichment of the class I alcohol dehydrogenase sequence polymorphism (ADH1BArg47His) in southern China and the adjacent areas suggests Darwinian positive selection on this genetic locus during Neolithic time though the driving force is yet to be disclosed.

Results: We studied a total of 38 populations (2,275 individuals) including Han Chinese, Tibetan and other ethnic populations across China. The geographic distribution of the ADH1B*47His allele in these populations indicates a clear east-to-west cline, and it is dominant in south-eastern populations but rare in Tibetan populations. The molecular dating suggests that the emergence of the ADH1B*47His allele occurred about 10,000 to approximately 7,000 years ago.

Conclusion: We present genetic evidence of selection on the ADH1BArg47His polymorphism caused by the emergence and expansion of rice domestication in East Asia. The geographic distribution of the ADH1B*47His allele in East Asia is consistent with the unearthed culture relic sites of rice domestication in China. The estimated origin time of ADH1B*47His allele in those populations coincides with the time of origin and expansion of Neolithic agriculture in southern China.

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