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Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study.

Hansson U, Toksvig-Larsen S, Ryd L, Aspenberg P - Acta Orthop (2009)

Bottom Line: We studied the effect of once-weekly treatment with alendronate after knee replacement.The treatment started postoperatively and continued on a weekly basis for 6 months.There was no difference in migration of implants between the two groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Lund University Hospital, Lund, Sweden. ulrik.hansson@med.lu.se

ABSTRACT

Background and purpose: Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement.

Patients and methods: We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years.

Results: There was no difference in migration of implants between the two groups.

Conclusion: With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.

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Rotation of the tibial components in 3 directions during the observation period.
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Figure 0001: Rotation of the tibial components in 3 directions during the observation period.

Mentions: Patient compliance regarding the pharmacological treatment was 90% in both groups. 2 patients in each group took less than 75% of the tablets. Both groups had similar RSA findings and no statistically significant difference was found (Figures 1–3). We found no significant differences regarding maximal total point motion (MTPM) at the 1- and 2-year follow-up RSA examinations (Table 2).


Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study.

Hansson U, Toksvig-Larsen S, Ryd L, Aspenberg P - Acta Orthop (2009)

Rotation of the tibial components in 3 directions during the observation period.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2823246&req=5

Figure 0001: Rotation of the tibial components in 3 directions during the observation period.
Mentions: Patient compliance regarding the pharmacological treatment was 90% in both groups. 2 patients in each group took less than 75% of the tablets. Both groups had similar RSA findings and no statistically significant difference was found (Figures 1–3). We found no significant differences regarding maximal total point motion (MTPM) at the 1- and 2-year follow-up RSA examinations (Table 2).

Bottom Line: We studied the effect of once-weekly treatment with alendronate after knee replacement.The treatment started postoperatively and continued on a weekly basis for 6 months.There was no difference in migration of implants between the two groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Lund University Hospital, Lund, Sweden. ulrik.hansson@med.lu.se

ABSTRACT

Background and purpose: Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement.

Patients and methods: We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years.

Results: There was no difference in migration of implants between the two groups.

Conclusion: With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.

Show MeSH
Related in: MedlinePlus