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Littoral cell angioma (LCA) associated with liver cirrhosis.

Kim HG, Park IS, Lee JI, Jeong S, Lee JW, Kwon KS, Lee DH, Kim PS, Kim HG, Shin YW, Kim YS, Ahn IS, Lee KY - Yonsei Med. J. (2005)

Bottom Line: A littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen.A thrombocytopenia was found on hematological evaluation.The histological and immunohistochemical features of the splenic specimens were consistent with a LCA.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Gastroenterology Division, Inha University Hospital, Inha University, 7-206, 3-ga, Shinheung-dong, Jung-gu, Incheon 400-103, Korea.

ABSTRACT
A littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen. A 60-year-old man, with multiple nodules in imaging study and liver cirrhosis graded as Child-Pugh classification class A, was transferred for splenomegaly. A thrombocytopenia was found on hematological evaluation. Because there was no evidence of hematological and visceral malignancy, a splenectomy was performed for a definitive diagnosis. The histological and immunohistochemical features of the splenic specimens were consistent with a LCA. After the splenectomy, the thrombocytopenia recovered to the normal platelet count. There has been no previous report of a LCA combined with liver cirrhosis. Herein, the first case of a LCA in Korea, diagnosed and treated by a splenectomy, is reported.

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Related in: MedlinePlus

Anastomosing vascular channels with a pseudopapillary pattern and exfoliated cells present in the luminal spaces of the vascular channels (H & E stain, × 400).
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Figure 4: Anastomosing vascular channels with a pseudopapillary pattern and exfoliated cells present in the luminal spaces of the vascular channels (H & E stain, × 400).

Mentions: The spleen weighed 370 grams and measured 13.0 × 9.0 × 5.5 cm. On the serial sections, there were multiple circumscribed blood-filled spongy like nodules of 0.2 to 0.6 cm in size (Fig. 3). The nodules showed proliferation of the thin-walled vascular channels covered by endothelial cells that presented no atypical aspects. There were anastomosing vascular channels that attain a pseudopapillary pattern. The channels were lined by tall or flat cells, with regular indented nuclei and infrequent mitoses. The luminal spaces of the vascular channels contained exfoliated cells (Fig. 4). The immunohistochemical staining of the lining cells showed positive for Factor VIII, CD31 and CD68, and negative for CD34 (Fig. 5). The histomorphological findings were consistent with a benign splenic Littoral cell angioma.


Littoral cell angioma (LCA) associated with liver cirrhosis.

Kim HG, Park IS, Lee JI, Jeong S, Lee JW, Kwon KS, Lee DH, Kim PS, Kim HG, Shin YW, Kim YS, Ahn IS, Lee KY - Yonsei Med. J. (2005)

Anastomosing vascular channels with a pseudopapillary pattern and exfoliated cells present in the luminal spaces of the vascular channels (H & E stain, × 400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2823050&req=5

Figure 4: Anastomosing vascular channels with a pseudopapillary pattern and exfoliated cells present in the luminal spaces of the vascular channels (H & E stain, × 400).
Mentions: The spleen weighed 370 grams and measured 13.0 × 9.0 × 5.5 cm. On the serial sections, there were multiple circumscribed blood-filled spongy like nodules of 0.2 to 0.6 cm in size (Fig. 3). The nodules showed proliferation of the thin-walled vascular channels covered by endothelial cells that presented no atypical aspects. There were anastomosing vascular channels that attain a pseudopapillary pattern. The channels were lined by tall or flat cells, with regular indented nuclei and infrequent mitoses. The luminal spaces of the vascular channels contained exfoliated cells (Fig. 4). The immunohistochemical staining of the lining cells showed positive for Factor VIII, CD31 and CD68, and negative for CD34 (Fig. 5). The histomorphological findings were consistent with a benign splenic Littoral cell angioma.

Bottom Line: A littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen.A thrombocytopenia was found on hematological evaluation.The histological and immunohistochemical features of the splenic specimens were consistent with a LCA.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Gastroenterology Division, Inha University Hospital, Inha University, 7-206, 3-ga, Shinheung-dong, Jung-gu, Incheon 400-103, Korea.

ABSTRACT
A littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen. A 60-year-old man, with multiple nodules in imaging study and liver cirrhosis graded as Child-Pugh classification class A, was transferred for splenomegaly. A thrombocytopenia was found on hematological evaluation. Because there was no evidence of hematological and visceral malignancy, a splenectomy was performed for a definitive diagnosis. The histological and immunohistochemical features of the splenic specimens were consistent with a LCA. After the splenectomy, the thrombocytopenia recovered to the normal platelet count. There has been no previous report of a LCA combined with liver cirrhosis. Herein, the first case of a LCA in Korea, diagnosed and treated by a splenectomy, is reported.

Show MeSH
Related in: MedlinePlus