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Warty squamous cell carcinoma of the vulva in older women: association with human papillomavirus.

Jang YH, Kim YC, Lee ES - Yonsei Med. J. (2005)

Bottom Line: We describe a rare case of WSCC with a short disease duration occurring in a woman of old age.We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray.These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Ajou University School of Medicine, San 5, Wonchon-dong, Yeongtong-gu, Suwon 443-721, Korea.

ABSTRACT
Warty squamous cell carcinoma (WSCC), a rare variant of squamous cell carcinoma occurring in younger women, is primarily associated with human papillomavirus (HPV) infection. Although WSCC appears to exhibit less aggressive behavior than typical well-differentiated squamous cell carcinoma, it bears the risk of regional metastasis. Accordingly, WSCC should be differentiated from other verruciform neoplasms. We describe a rare case of WSCC with a short disease duration occurring in a woman of old age. We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray. These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.

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Related in: MedlinePlus

HPV DNA chip microarray format (Left). DNA chip microarray for HPV types show the presence of other type HPV DNA in this case, but not the high and low risk HPV types. (Left: DNA chip microarray format; right: results in this case, other HPV DNA types positive.)
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Related In: Results  -  Collection

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Figure 3: HPV DNA chip microarray format (Left). DNA chip microarray for HPV types show the presence of other type HPV DNA in this case, but not the high and low risk HPV types. (Left: DNA chip microarray format; right: results in this case, other HPV DNA types positive.)

Mentions: In our case, the DNA microarray showed the existence of other types of HPV DNA, but not the 18 high risk and 14 low risk HPV types (Fig. 3).


Warty squamous cell carcinoma of the vulva in older women: association with human papillomavirus.

Jang YH, Kim YC, Lee ES - Yonsei Med. J. (2005)

HPV DNA chip microarray format (Left). DNA chip microarray for HPV types show the presence of other type HPV DNA in this case, but not the high and low risk HPV types. (Left: DNA chip microarray format; right: results in this case, other HPV DNA types positive.)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2823042&req=5

Figure 3: HPV DNA chip microarray format (Left). DNA chip microarray for HPV types show the presence of other type HPV DNA in this case, but not the high and low risk HPV types. (Left: DNA chip microarray format; right: results in this case, other HPV DNA types positive.)
Mentions: In our case, the DNA microarray showed the existence of other types of HPV DNA, but not the 18 high risk and 14 low risk HPV types (Fig. 3).

Bottom Line: We describe a rare case of WSCC with a short disease duration occurring in a woman of old age.We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray.These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Ajou University School of Medicine, San 5, Wonchon-dong, Yeongtong-gu, Suwon 443-721, Korea.

ABSTRACT
Warty squamous cell carcinoma (WSCC), a rare variant of squamous cell carcinoma occurring in younger women, is primarily associated with human papillomavirus (HPV) infection. Although WSCC appears to exhibit less aggressive behavior than typical well-differentiated squamous cell carcinoma, it bears the risk of regional metastasis. Accordingly, WSCC should be differentiated from other verruciform neoplasms. We describe a rare case of WSCC with a short disease duration occurring in a woman of old age. We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray. These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.

Show MeSH
Related in: MedlinePlus