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Warty squamous cell carcinoma of the vulva in older women: association with human papillomavirus.

Jang YH, Kim YC, Lee ES - Yonsei Med. J. (2005)

Bottom Line: We describe a rare case of WSCC with a short disease duration occurring in a woman of old age.We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray.These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Ajou University School of Medicine, San 5, Wonchon-dong, Yeongtong-gu, Suwon 443-721, Korea.

ABSTRACT
Warty squamous cell carcinoma (WSCC), a rare variant of squamous cell carcinoma occurring in younger women, is primarily associated with human papillomavirus (HPV) infection. Although WSCC appears to exhibit less aggressive behavior than typical well-differentiated squamous cell carcinoma, it bears the risk of regional metastasis. Accordingly, WSCC should be differentiated from other verruciform neoplasms. We describe a rare case of WSCC with a short disease duration occurring in a woman of old age. We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray. These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.

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(a) A papillomatous pattern with hyperkeratosis, parakeratosis and acanthosis (haematoxylin and eosin; original magnification: × 40). Round and tapering dermal papillae with a fibrovascular core (×100). (b) Invasion of the dermis by irregularly shaped, jagged nests of epithelium, the cells which are predominantly mature squamous cells showing atypicality (haematoxylin and eosin; original magnification: ×50). The invading tumor masses are composed of atypical squamous cells (× 200). (c) Cells within the tumor nest demonstrate koilocytosis with large, wrinkled, hyperchromatic nuclei, and horn pearl is present (haematoxylin and eosin; original magnification: ×400).
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Figure 2: (a) A papillomatous pattern with hyperkeratosis, parakeratosis and acanthosis (haematoxylin and eosin; original magnification: × 40). Round and tapering dermal papillae with a fibrovascular core (×100). (b) Invasion of the dermis by irregularly shaped, jagged nests of epithelium, the cells which are predominantly mature squamous cells showing atypicality (haematoxylin and eosin; original magnification: ×50). The invading tumor masses are composed of atypical squamous cells (× 200). (c) Cells within the tumor nest demonstrate koilocytosis with large, wrinkled, hyperchromatic nuclei, and horn pearl is present (haematoxylin and eosin; original magnification: ×400).

Mentions: We performed an excisional biopsy. The biopsy specimen revealed a papillomatous pattern with hyperkeratosis, parakeratosis and acanthosis. The dermal papillae had round or tapering, pointed ("spiked") tips, and a central thin fibrovascular core (Fig. 2a). At the deep margin, the tumor invaded the adjacent tissue in the form of irregularly shaped, jagged nests of epithelium. The dermis showed a marked inflammatory reaction (Fig. 2b). Cells within the nests showed mitotic figures, and their nuclei were large, wrinkled, hyperchromatic, with frequent binucleation and multinucleation (Fig. 2c). The lateral margin of the resected specimen showed focal extension of the carcinoma.


Warty squamous cell carcinoma of the vulva in older women: association with human papillomavirus.

Jang YH, Kim YC, Lee ES - Yonsei Med. J. (2005)

(a) A papillomatous pattern with hyperkeratosis, parakeratosis and acanthosis (haematoxylin and eosin; original magnification: × 40). Round and tapering dermal papillae with a fibrovascular core (×100). (b) Invasion of the dermis by irregularly shaped, jagged nests of epithelium, the cells which are predominantly mature squamous cells showing atypicality (haematoxylin and eosin; original magnification: ×50). The invading tumor masses are composed of atypical squamous cells (× 200). (c) Cells within the tumor nest demonstrate koilocytosis with large, wrinkled, hyperchromatic nuclei, and horn pearl is present (haematoxylin and eosin; original magnification: ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2823042&req=5

Figure 2: (a) A papillomatous pattern with hyperkeratosis, parakeratosis and acanthosis (haematoxylin and eosin; original magnification: × 40). Round and tapering dermal papillae with a fibrovascular core (×100). (b) Invasion of the dermis by irregularly shaped, jagged nests of epithelium, the cells which are predominantly mature squamous cells showing atypicality (haematoxylin and eosin; original magnification: ×50). The invading tumor masses are composed of atypical squamous cells (× 200). (c) Cells within the tumor nest demonstrate koilocytosis with large, wrinkled, hyperchromatic nuclei, and horn pearl is present (haematoxylin and eosin; original magnification: ×400).
Mentions: We performed an excisional biopsy. The biopsy specimen revealed a papillomatous pattern with hyperkeratosis, parakeratosis and acanthosis. The dermal papillae had round or tapering, pointed ("spiked") tips, and a central thin fibrovascular core (Fig. 2a). At the deep margin, the tumor invaded the adjacent tissue in the form of irregularly shaped, jagged nests of epithelium. The dermis showed a marked inflammatory reaction (Fig. 2b). Cells within the nests showed mitotic figures, and their nuclei were large, wrinkled, hyperchromatic, with frequent binucleation and multinucleation (Fig. 2c). The lateral margin of the resected specimen showed focal extension of the carcinoma.

Bottom Line: We describe a rare case of WSCC with a short disease duration occurring in a woman of old age.We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray.These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Ajou University School of Medicine, San 5, Wonchon-dong, Yeongtong-gu, Suwon 443-721, Korea.

ABSTRACT
Warty squamous cell carcinoma (WSCC), a rare variant of squamous cell carcinoma occurring in younger women, is primarily associated with human papillomavirus (HPV) infection. Although WSCC appears to exhibit less aggressive behavior than typical well-differentiated squamous cell carcinoma, it bears the risk of regional metastasis. Accordingly, WSCC should be differentiated from other verruciform neoplasms. We describe a rare case of WSCC with a short disease duration occurring in a woman of old age. We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray. These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.

Show MeSH
Related in: MedlinePlus