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Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases.

Karpov PA, Nadezhdina ES, Yemets AI, Matusov VG, Nyporko AY, Shashina NY, Blume YB - BMC Genomics (2010)

Bottom Line: A number of SLK, MAST2 and AURKA plant homologues were identified.The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase).Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine. karpov.p.a@gmail.com

ABSTRACT
A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

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Phylogenetic tree of STK6_HUMAN (Aurora A) kinase and its plant homologues demonstrating their phylogenetic relationships. Highlighted are the proteins identified in the paper.
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Figure 8: Phylogenetic tree of STK6_HUMAN (Aurora A) kinase and its plant homologues demonstrating their phylogenetic relationships. Highlighted are the proteins identified in the paper.

Mentions: As a result of highly conserved positions of the functionally important residues and motifs, together with homology of a primary sequence and domains (analysis using domain profiles and hidden Markov models) all S_TKc kinases were identified as plant structural and functional homologues of human Aurora A. Based on the cladistic analysis (Figure 8), the closest homologue of STK6_HUMAN was a protein of unknown function, A7PY12/GSVIVT00026259001 from V. vinifera (identity-76%, similarity-56%, E-value = 3e-91).


Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases.

Karpov PA, Nadezhdina ES, Yemets AI, Matusov VG, Nyporko AY, Shashina NY, Blume YB - BMC Genomics (2010)

Phylogenetic tree of STK6_HUMAN (Aurora A) kinase and its plant homologues demonstrating their phylogenetic relationships. Highlighted are the proteins identified in the paper.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822528&req=5

Figure 8: Phylogenetic tree of STK6_HUMAN (Aurora A) kinase and its plant homologues demonstrating their phylogenetic relationships. Highlighted are the proteins identified in the paper.
Mentions: As a result of highly conserved positions of the functionally important residues and motifs, together with homology of a primary sequence and domains (analysis using domain profiles and hidden Markov models) all S_TKc kinases were identified as plant structural and functional homologues of human Aurora A. Based on the cladistic analysis (Figure 8), the closest homologue of STK6_HUMAN was a protein of unknown function, A7PY12/GSVIVT00026259001 from V. vinifera (identity-76%, similarity-56%, E-value = 3e-91).

Bottom Line: A number of SLK, MAST2 and AURKA plant homologues were identified.The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase).Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine. karpov.p.a@gmail.com

ABSTRACT
A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

Show MeSH