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Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases.

Karpov PA, Nadezhdina ES, Yemets AI, Matusov VG, Nyporko AY, Shashina NY, Blume YB - BMC Genomics (2010)

Bottom Line: A number of SLK, MAST2 and AURKA plant homologues were identified.The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase).Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine. karpov.p.a@gmail.com

ABSTRACT
A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

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Phylogenetic tree built for H. sapiens MAST2 kinase and its plant homologues; * - plant homologues containing typical for animal MAST2 kinases auxiliary S_TK_X catalytic S_TK_X domain.
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Figure 5: Phylogenetic tree built for H. sapiens MAST2 kinase and its plant homologues; * - plant homologues containing typical for animal MAST2 kinases auxiliary S_TK_X catalytic S_TK_X domain.

Mentions: Phylogenetic analysis using Neighbour-Joining algorithm based on catalytic domain similarity demonstrated that a common clade with human MAST2 is formed by the following plant homologues: Q0WLU7/At1g45160, Q9LE81/At5g62310 (A. thaliana), A7NTE9_VITVI*/GSVIVT00014640001, A5BWH0_VITVI*/VITISV_001730 (V. vinifera) and Q32YB5/GenBank: AY770392.1 (M. truncatula) (Figure 5).


Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases.

Karpov PA, Nadezhdina ES, Yemets AI, Matusov VG, Nyporko AY, Shashina NY, Blume YB - BMC Genomics (2010)

Phylogenetic tree built for H. sapiens MAST2 kinase and its plant homologues; * - plant homologues containing typical for animal MAST2 kinases auxiliary S_TK_X catalytic S_TK_X domain.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822528&req=5

Figure 5: Phylogenetic tree built for H. sapiens MAST2 kinase and its plant homologues; * - plant homologues containing typical for animal MAST2 kinases auxiliary S_TK_X catalytic S_TK_X domain.
Mentions: Phylogenetic analysis using Neighbour-Joining algorithm based on catalytic domain similarity demonstrated that a common clade with human MAST2 is formed by the following plant homologues: Q0WLU7/At1g45160, Q9LE81/At5g62310 (A. thaliana), A7NTE9_VITVI*/GSVIVT00014640001, A5BWH0_VITVI*/VITISV_001730 (V. vinifera) and Q32YB5/GenBank: AY770392.1 (M. truncatula) (Figure 5).

Bottom Line: A number of SLK, MAST2 and AURKA plant homologues were identified.The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase).Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine. karpov.p.a@gmail.com

ABSTRACT
A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.

Show MeSH