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Dorsal arthrodesis in prepubertal New Zealand white rabbits followed to skeletal maturity: Effect on thoracic dimensions, spine growth and neural elements.

Canavese F, Dimeglio A, D'Amato C, Volpatti D, Granier M, Stebel M, Cavalli F, Canavese B - Indian J Orthop (2010)

Bottom Line: The sternum as well as length of thoracic vertebral bodies in the spinal segment T1-T6 show reduced growth.Observed spine height and chest dimension values were reduced compared to the expected norms.The thorax becomes elliptical as chest depth grows less than chest width.

View Article: PubMed Central - PubMed

Affiliation: Service de Chirurgie Orthopédique Pédiatrique - CHU Hôpital Lapeyronie, 371, Avenue du Doyen G. Giraud 34295 Montpellier, France.

ABSTRACT

Background: Several studies have shown that severe spinal deformity and early arthrodesis can adversely affect the development of the spine and thorax by changing their shape and reducing their normal function. This article analyzes the consequences of posterior fusion on the growth of spine, thorax and neural elements in New Zealand white rabbits and compares with similar human data.

Materials and methods: The first section of the article analyzes the consequences of T1-T6 dorsal arthrodesis on the growth of the spine, sternum, thorax volume and neural elements in 12 prepubertal female New Zealand white rabbits, through a study of CT scans and histology specimens. The second part, evaluates thoracic dimensions in 21 children with spinal arthrodesis for treatment of deformity performed prior to nine years of age.

Results: Dorsal arthrodesis in prepubertal rabbits changes thoracic growth patterns. In operated rabbits thoracic depth grows more slowly than thoracic width. The sternum as well as length of thoracic vertebral bodies in the spinal segment T1-T6 show reduced growth. Children undergoing spinal arthrodesis before nine years of age were noted to have shortened height, short trunk and disproportionate body habitus at skeletal maturity. Observed spine height and chest dimension values were reduced compared to the expected norms. The ratio between chest width and chest depth was below normal values.

Conclusions: The first part of the study shows that thoracic dorsal arthrodesis in prepubertal New Zealand white rabbit influences thoracic, spine growth and affects the shape of pseudo unipolar neurons of the dorsal root ganglia. The second part demonstrates that children treated before nine years of age have significantly reduced spine height and thoracic dimensions. The thorax becomes elliptical as chest depth grows less than chest width. Both experimental and clinical findings contribute to explain reduced chest growth and subsequent thoracic growth disturbance in patients treated with early arthrodesis.

No MeSH data available.


Related in: MedlinePlus

Photomicrograph taken through two adjacent end plates of arthrodesed rabbits depicting disorganization of the annulus fibrosus with some area of ossification of two adjacent end plates
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Figure 0002: Photomicrograph taken through two adjacent end plates of arthrodesed rabbits depicting disorganization of the annulus fibrosus with some area of ossification of two adjacent end plates

Mentions: Arthrodesed rabbits showed disorganization of the annulus fibrosus with some areas of ossification connecting adjacent end plates [Figure 2]. Intervertebral joint and costovertebral joints showed cartilage degeneration and loss of congruence but no sign of ossification or fusion. Increased vascularization was found in surrounding tissues. Two populations of neurons were identified in the root ganglia of arthrodesed rabbits: one normal and one with abnormal changes. These changes included neurons with smaller and irregular perykarion, abnormal shape and atypical Nissl substance distribution. Additionally, the architecture of the satellite cells sheath appeared disorganized [Figure 3]. The radicular motor neurons showed homogeneous Nissl substance distribution and the spinal cord appeared overall normal.


Dorsal arthrodesis in prepubertal New Zealand white rabbits followed to skeletal maturity: Effect on thoracic dimensions, spine growth and neural elements.

Canavese F, Dimeglio A, D'Amato C, Volpatti D, Granier M, Stebel M, Cavalli F, Canavese B - Indian J Orthop (2010)

Photomicrograph taken through two adjacent end plates of arthrodesed rabbits depicting disorganization of the annulus fibrosus with some area of ossification of two adjacent end plates
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822414&req=5

Figure 0002: Photomicrograph taken through two adjacent end plates of arthrodesed rabbits depicting disorganization of the annulus fibrosus with some area of ossification of two adjacent end plates
Mentions: Arthrodesed rabbits showed disorganization of the annulus fibrosus with some areas of ossification connecting adjacent end plates [Figure 2]. Intervertebral joint and costovertebral joints showed cartilage degeneration and loss of congruence but no sign of ossification or fusion. Increased vascularization was found in surrounding tissues. Two populations of neurons were identified in the root ganglia of arthrodesed rabbits: one normal and one with abnormal changes. These changes included neurons with smaller and irregular perykarion, abnormal shape and atypical Nissl substance distribution. Additionally, the architecture of the satellite cells sheath appeared disorganized [Figure 3]. The radicular motor neurons showed homogeneous Nissl substance distribution and the spinal cord appeared overall normal.

Bottom Line: The sternum as well as length of thoracic vertebral bodies in the spinal segment T1-T6 show reduced growth.Observed spine height and chest dimension values were reduced compared to the expected norms.The thorax becomes elliptical as chest depth grows less than chest width.

View Article: PubMed Central - PubMed

Affiliation: Service de Chirurgie Orthopédique Pédiatrique - CHU Hôpital Lapeyronie, 371, Avenue du Doyen G. Giraud 34295 Montpellier, France.

ABSTRACT

Background: Several studies have shown that severe spinal deformity and early arthrodesis can adversely affect the development of the spine and thorax by changing their shape and reducing their normal function. This article analyzes the consequences of posterior fusion on the growth of spine, thorax and neural elements in New Zealand white rabbits and compares with similar human data.

Materials and methods: The first section of the article analyzes the consequences of T1-T6 dorsal arthrodesis on the growth of the spine, sternum, thorax volume and neural elements in 12 prepubertal female New Zealand white rabbits, through a study of CT scans and histology specimens. The second part, evaluates thoracic dimensions in 21 children with spinal arthrodesis for treatment of deformity performed prior to nine years of age.

Results: Dorsal arthrodesis in prepubertal rabbits changes thoracic growth patterns. In operated rabbits thoracic depth grows more slowly than thoracic width. The sternum as well as length of thoracic vertebral bodies in the spinal segment T1-T6 show reduced growth. Children undergoing spinal arthrodesis before nine years of age were noted to have shortened height, short trunk and disproportionate body habitus at skeletal maturity. Observed spine height and chest dimension values were reduced compared to the expected norms. The ratio between chest width and chest depth was below normal values.

Conclusions: The first part of the study shows that thoracic dorsal arthrodesis in prepubertal New Zealand white rabbit influences thoracic, spine growth and affects the shape of pseudo unipolar neurons of the dorsal root ganglia. The second part demonstrates that children treated before nine years of age have significantly reduced spine height and thoracic dimensions. The thorax becomes elliptical as chest depth grows less than chest width. Both experimental and clinical findings contribute to explain reduced chest growth and subsequent thoracic growth disturbance in patients treated with early arthrodesis.

No MeSH data available.


Related in: MedlinePlus