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Autoimmune hemolytic anemia in a patient with primary ovarian non-Hodgkin's lymphoma.

Jung CK, Park JS, Lee EJ, Kim SH, Kwon HC, Kim JS, Roh MS, Yoon SK, Kim KH, Han JY, Kim HJ - J. Korean Med. Sci. (2004)

Bottom Line: The primary ovarian lymphoma is a rare disease with poor prognosis.The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%.We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea.

ABSTRACT
The primary ovarian lymphoma is a rare disease with poor prognosis. The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%. However, a substantial portion of the previously reported cases of ovarian lymphoma actually represented ovarian involvement by more diffuse lymphomatous process. If stringent criteria are used for case selection, true primary ovarian lymphoma usually carries a favorable prognosis. We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient. After ablative surgery, the hemoglobin level and the reticulocyte count were normalized. One year following surgery and chemotherapy, the patient is alive and disease free.

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Related in: MedlinePlus

Medium-power view of the lesion shows an organoid with small rounded nests of tumor cells surrounded by thin fibrous septae (hematoxylin and eosin, ×100).
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Figure 3: Medium-power view of the lesion shows an organoid with small rounded nests of tumor cells surrounded by thin fibrous septae (hematoxylin and eosin, ×100).

Mentions: The patient was treated with prednisolone 1 mg/kg daily. The dosage of prednisolone was gradually tapered to 7.5 mg over the next 3 months. In November 2001, exploratory laparotomy revealed a 14 cm sized multinodular mass involving the right ovary. The mass was not adherent to the adjacent organs and was removed with the right Fallopian tube without difficulty. The left Fallopian tube, ovary, uterus, and kidneys were normal. The liver, diaphragm, and omentum were not involved. No enlarged lymph node, more than 1 cm size, was identified in the abdomen. Peritoneal washing was performed and the pathology finding revealed no abnormal cells. On gross examination, the right ovarian mass measured 14×10×9 cm. The cut surface of the ovarian mass revealed a solid, multilobulated tumor (Fig. 2). Microscopic examination revealed complete replacement of the ovarian tissue by sheets of neoplastic cells (Fig. 3). Paraffin immunoperoxidase studies showed strong positive marking of the neoplastic cell for CD45 (LCA) and CD20 (L-26).


Autoimmune hemolytic anemia in a patient with primary ovarian non-Hodgkin's lymphoma.

Jung CK, Park JS, Lee EJ, Kim SH, Kwon HC, Kim JS, Roh MS, Yoon SK, Kim KH, Han JY, Kim HJ - J. Korean Med. Sci. (2004)

Medium-power view of the lesion shows an organoid with small rounded nests of tumor cells surrounded by thin fibrous septae (hematoxylin and eosin, ×100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822315&req=5

Figure 3: Medium-power view of the lesion shows an organoid with small rounded nests of tumor cells surrounded by thin fibrous septae (hematoxylin and eosin, ×100).
Mentions: The patient was treated with prednisolone 1 mg/kg daily. The dosage of prednisolone was gradually tapered to 7.5 mg over the next 3 months. In November 2001, exploratory laparotomy revealed a 14 cm sized multinodular mass involving the right ovary. The mass was not adherent to the adjacent organs and was removed with the right Fallopian tube without difficulty. The left Fallopian tube, ovary, uterus, and kidneys were normal. The liver, diaphragm, and omentum were not involved. No enlarged lymph node, more than 1 cm size, was identified in the abdomen. Peritoneal washing was performed and the pathology finding revealed no abnormal cells. On gross examination, the right ovarian mass measured 14×10×9 cm. The cut surface of the ovarian mass revealed a solid, multilobulated tumor (Fig. 2). Microscopic examination revealed complete replacement of the ovarian tissue by sheets of neoplastic cells (Fig. 3). Paraffin immunoperoxidase studies showed strong positive marking of the neoplastic cell for CD45 (LCA) and CD20 (L-26).

Bottom Line: The primary ovarian lymphoma is a rare disease with poor prognosis.The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%.We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea.

ABSTRACT
The primary ovarian lymphoma is a rare disease with poor prognosis. The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%. However, a substantial portion of the previously reported cases of ovarian lymphoma actually represented ovarian involvement by more diffuse lymphomatous process. If stringent criteria are used for case selection, true primary ovarian lymphoma usually carries a favorable prognosis. We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient. After ablative surgery, the hemoglobin level and the reticulocyte count were normalized. One year following surgery and chemotherapy, the patient is alive and disease free.

Show MeSH
Related in: MedlinePlus