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Autoimmune hemolytic anemia in a patient with primary ovarian non-Hodgkin's lymphoma.

Jung CK, Park JS, Lee EJ, Kim SH, Kwon HC, Kim JS, Roh MS, Yoon SK, Kim KH, Han JY, Kim HJ - J. Korean Med. Sci. (2004)

Bottom Line: The primary ovarian lymphoma is a rare disease with poor prognosis.The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%.We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea.

ABSTRACT
The primary ovarian lymphoma is a rare disease with poor prognosis. The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%. However, a substantial portion of the previously reported cases of ovarian lymphoma actually represented ovarian involvement by more diffuse lymphomatous process. If stringent criteria are used for case selection, true primary ovarian lymphoma usually carries a favorable prognosis. We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient. After ablative surgery, the hemoglobin level and the reticulocyte count were normalized. One year following surgery and chemotherapy, the patient is alive and disease free.

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Pelvis MRI showing a large mass in the pelvic cavity.
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Figure 1: Pelvis MRI showing a large mass in the pelvic cavity.

Mentions: In September 2001, a 29-yr-old woman with low abdominal pain visited our emergency room. Laboratory data showed a hemoglobin level of 6.7 g/dL and a reticulocyte count of 7.2%. Serum direct/indirect bilirubin levels were 3.2/1.0 mg/dL. The lactate dehydrogenase level was 2,450 U/L. The direct and indirect Coomb's tests were positive. The erythrocyte sedimentation rate was 30 mm/hr. The C-reactive protein was not increased. The anti-nuclear antibody and anti-double-stranded DNA antibody were absent. The complement level was normal. Peripheral blood smear showed a normocytic normochromic anemia with red blood cell agglutination. The pelvis MRI showed a well marginated pelvic cavity mass (Fig. 1). We suspected a myoma or a solid adnexal tumor accompanied by AIHA. We concluded that AIHA should be treated first, and then exploratory laparotomy be needed.


Autoimmune hemolytic anemia in a patient with primary ovarian non-Hodgkin's lymphoma.

Jung CK, Park JS, Lee EJ, Kim SH, Kwon HC, Kim JS, Roh MS, Yoon SK, Kim KH, Han JY, Kim HJ - J. Korean Med. Sci. (2004)

Pelvis MRI showing a large mass in the pelvic cavity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822315&req=5

Figure 1: Pelvis MRI showing a large mass in the pelvic cavity.
Mentions: In September 2001, a 29-yr-old woman with low abdominal pain visited our emergency room. Laboratory data showed a hemoglobin level of 6.7 g/dL and a reticulocyte count of 7.2%. Serum direct/indirect bilirubin levels were 3.2/1.0 mg/dL. The lactate dehydrogenase level was 2,450 U/L. The direct and indirect Coomb's tests were positive. The erythrocyte sedimentation rate was 30 mm/hr. The C-reactive protein was not increased. The anti-nuclear antibody and anti-double-stranded DNA antibody were absent. The complement level was normal. Peripheral blood smear showed a normocytic normochromic anemia with red blood cell agglutination. The pelvis MRI showed a well marginated pelvic cavity mass (Fig. 1). We suspected a myoma or a solid adnexal tumor accompanied by AIHA. We concluded that AIHA should be treated first, and then exploratory laparotomy be needed.

Bottom Line: The primary ovarian lymphoma is a rare disease with poor prognosis.The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%.We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea.

ABSTRACT
The primary ovarian lymphoma is a rare disease with poor prognosis. The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%. However, a substantial portion of the previously reported cases of ovarian lymphoma actually represented ovarian involvement by more diffuse lymphomatous process. If stringent criteria are used for case selection, true primary ovarian lymphoma usually carries a favorable prognosis. We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient. After ablative surgery, the hemoglobin level and the reticulocyte count were normalized. One year following surgery and chemotherapy, the patient is alive and disease free.

Show MeSH
Related in: MedlinePlus