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X-chromosome inactivation patterns in Korean women with idiopathic recurrent spontaneous abortion.

Kim JW, Park SY, Kim YM, Kim JM, Han JY, Ryu HM - J. Korean Med. Sci. (2004)

Bottom Line: Recent reports observed a significant association between highly skewed X chromosome and RSA, supporting that X chromosome inactivation might be an important and previously unknown cause of RSA.The frequency of skewed X inactivation between RSA patients and control group was not significantly different (p>0.05).This finding suggests that skewed x chromosome be not associated with unexplained RSA patients.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Medical Genetics, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Recurrent spontaneous abortion (RSA) defines as two or more consecutive losses at < or = 20 weeks of gestation and affects an estimated 1 of every 100 couples wishing to have children. However, it remains a poorly understood phenomenon. Recent reports observed a significant association between highly skewed X chromosome and RSA, supporting that X chromosome inactivation might be an important and previously unknown cause of RSA. X-inactivation pattern, using polymeric X-linked women with idiopathic RSA and 80 control subjects with a single successful pregnancy and no history of spontaneous abortion. The ratio of heterozygotes was 68.2% (45/66) in women with RSA and 67.5% (54/80) in control group. Among 45 informative RSA cases, only 1 (2.2%) woman showed extreme skewed X inactivation (> or = 90%) and 4 (8.9%) had mild skewed inactivation (> or = 85%). In 54 heterozygous control subjects, 5 (9.3%) women showed extreme skewed X inactivation and 7 (13.0%) had mild one. The frequency of skewed X inactivation between RSA patients and control group was not significantly different (p>0.05). This finding suggests that skewed x chromosome be not associated with unexplained RSA patients.

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Related in: MedlinePlus

Comparison of age patterns in patients with RSA and control females. No significant difference in age was observed between two groups (p=0.457)
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Figure 1: Comparison of age patterns in patients with RSA and control females. No significant difference in age was observed between two groups (p=0.457)

Mentions: Between November 2001 and February 2003, 66 Korean women were collected as having recurrent pregnancy loss as defined by having 2 or more consecutive abortion and having RSA of unknown cause. Subjects presented with no other phenotypic abnormalities and with each pregnancy documented by a positive result on serum hCG, ultrasound or pathology. Also, subjects and those husbands had a normal karyotype. The mean age of patients was 33.5±0.5 yr, with a range of 27-43 yr. The mean number of consecutive spontaneous abortion per patient was 2.9, with range of 2-12. Control group included 80 healthy Korean women who had given birth to more than one child and no history of spontaneous or elective abortion. The mean age of control females was 33.9±0.4 yr, with a range of 27-43 yr. No significant difference in age was observed between RSA women and control group (p=0.457) (Fig. 1).


X-chromosome inactivation patterns in Korean women with idiopathic recurrent spontaneous abortion.

Kim JW, Park SY, Kim YM, Kim JM, Han JY, Ryu HM - J. Korean Med. Sci. (2004)

Comparison of age patterns in patients with RSA and control females. No significant difference in age was observed between two groups (p=0.457)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822308&req=5

Figure 1: Comparison of age patterns in patients with RSA and control females. No significant difference in age was observed between two groups (p=0.457)
Mentions: Between November 2001 and February 2003, 66 Korean women were collected as having recurrent pregnancy loss as defined by having 2 or more consecutive abortion and having RSA of unknown cause. Subjects presented with no other phenotypic abnormalities and with each pregnancy documented by a positive result on serum hCG, ultrasound or pathology. Also, subjects and those husbands had a normal karyotype. The mean age of patients was 33.5±0.5 yr, with a range of 27-43 yr. The mean number of consecutive spontaneous abortion per patient was 2.9, with range of 2-12. Control group included 80 healthy Korean women who had given birth to more than one child and no history of spontaneous or elective abortion. The mean age of control females was 33.9±0.4 yr, with a range of 27-43 yr. No significant difference in age was observed between RSA women and control group (p=0.457) (Fig. 1).

Bottom Line: Recent reports observed a significant association between highly skewed X chromosome and RSA, supporting that X chromosome inactivation might be an important and previously unknown cause of RSA.The frequency of skewed X inactivation between RSA patients and control group was not significantly different (p>0.05).This finding suggests that skewed x chromosome be not associated with unexplained RSA patients.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Medical Genetics, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
Recurrent spontaneous abortion (RSA) defines as two or more consecutive losses at < or = 20 weeks of gestation and affects an estimated 1 of every 100 couples wishing to have children. However, it remains a poorly understood phenomenon. Recent reports observed a significant association between highly skewed X chromosome and RSA, supporting that X chromosome inactivation might be an important and previously unknown cause of RSA. X-inactivation pattern, using polymeric X-linked women with idiopathic RSA and 80 control subjects with a single successful pregnancy and no history of spontaneous abortion. The ratio of heterozygotes was 68.2% (45/66) in women with RSA and 67.5% (54/80) in control group. Among 45 informative RSA cases, only 1 (2.2%) woman showed extreme skewed X inactivation (> or = 90%) and 4 (8.9%) had mild skewed inactivation (> or = 85%). In 54 heterozygous control subjects, 5 (9.3%) women showed extreme skewed X inactivation and 7 (13.0%) had mild one. The frequency of skewed X inactivation between RSA patients and control group was not significantly different (p>0.05). This finding suggests that skewed x chromosome be not associated with unexplained RSA patients.

Show MeSH
Related in: MedlinePlus