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Bone marrow is involved in less than 10% of patients with nasal-type NK/T cell lymphoma at initial diagnosis.

Sung CO, Ko YH - J. Korean Med. Sci. (2004)

Bottom Line: Two patients had a disseminated disease at diagnosis and died 6 days and 214 days after diagnosis.One patient had diffuse colonic lesion and died 82 days later.In conclusion, marrow involvement in nasal NK/T cell lymphoma is infrequent at initial diagnosis, and EBV ISH is a useful technique for identifying the minor subgroup of patients which have easily overlooked neoplastic involvement.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.

ABSTRACT
To evaluate the frequency of bone marrow involvement by nasal-type NK/T cell lymphoma, we retrospectively studied biopsy specimens from 40 patients by EBV in situ hybridization (ISH). Three patients had marrow involvement at initial diagnosis (7.5%). In one patient (1/40, 2.5%), the disease in bone marrow was recognized by routine morphological assessment, while two other patients had minimal involvement of lymphoma cells which was recognized only by EBV in situ hybridization (2/40, 5%). Two patients had a disseminated disease at diagnosis and died 6 days and 214 days after diagnosis. One patient had diffuse colonic lesion and died 82 days later. In conclusion, marrow involvement in nasal NK/T cell lymphoma is infrequent at initial diagnosis, and EBV ISH is a useful technique for identifying the minor subgroup of patients which have easily overlooked neoplastic involvement.

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Case 2 showing bone marrow involvement by NK/T cell lymphoma, which is identified by HE stain (A) as well as by EBV in-situ hybridization (B).
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Figure 1: Case 2 showing bone marrow involvement by NK/T cell lymphoma, which is identified by HE stain (A) as well as by EBV in-situ hybridization (B).

Mentions: Among the bone marrow biopsy specimens obtained from the patients for initial diagnosis, only 3 (7.5%) showed evidence of involvement by NK/T cell lymphoma. In one patient, the neoplastic involvement was recognized by hematoxylineosin stain and immunohistochemistry for pCD3 as well as EBV ISH (1/40, 2.5%) (Fig. 1). The patient had a disseminated disease involving the eye, liver, pancreas, and abdominal lymph node, and died 6 days after the diagnosis. In the other two patients, the disease in the bone marrow was not suspected by routine hematoxylin-eosin stain and immunohistochemistry for pCD3, but recognized by EBV ISH (2/40, 5%) (Fig. 2). One of the last two patients showed disseminated disease involving the liver, spleen, and nasopharynx, and died 214 days after diagnosis. The other had diffuse lesions confined to the colon and pursued aggressive clinical course with colonic perforation but died 82 days after diagnosis.


Bone marrow is involved in less than 10% of patients with nasal-type NK/T cell lymphoma at initial diagnosis.

Sung CO, Ko YH - J. Korean Med. Sci. (2004)

Case 2 showing bone marrow involvement by NK/T cell lymphoma, which is identified by HE stain (A) as well as by EBV in-situ hybridization (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822304&req=5

Figure 1: Case 2 showing bone marrow involvement by NK/T cell lymphoma, which is identified by HE stain (A) as well as by EBV in-situ hybridization (B).
Mentions: Among the bone marrow biopsy specimens obtained from the patients for initial diagnosis, only 3 (7.5%) showed evidence of involvement by NK/T cell lymphoma. In one patient, the neoplastic involvement was recognized by hematoxylineosin stain and immunohistochemistry for pCD3 as well as EBV ISH (1/40, 2.5%) (Fig. 1). The patient had a disseminated disease involving the eye, liver, pancreas, and abdominal lymph node, and died 6 days after the diagnosis. In the other two patients, the disease in the bone marrow was not suspected by routine hematoxylin-eosin stain and immunohistochemistry for pCD3, but recognized by EBV ISH (2/40, 5%) (Fig. 2). One of the last two patients showed disseminated disease involving the liver, spleen, and nasopharynx, and died 214 days after diagnosis. The other had diffuse lesions confined to the colon and pursued aggressive clinical course with colonic perforation but died 82 days after diagnosis.

Bottom Line: Two patients had a disseminated disease at diagnosis and died 6 days and 214 days after diagnosis.One patient had diffuse colonic lesion and died 82 days later.In conclusion, marrow involvement in nasal NK/T cell lymphoma is infrequent at initial diagnosis, and EBV ISH is a useful technique for identifying the minor subgroup of patients which have easily overlooked neoplastic involvement.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.

ABSTRACT
To evaluate the frequency of bone marrow involvement by nasal-type NK/T cell lymphoma, we retrospectively studied biopsy specimens from 40 patients by EBV in situ hybridization (ISH). Three patients had marrow involvement at initial diagnosis (7.5%). In one patient (1/40, 2.5%), the disease in bone marrow was recognized by routine morphological assessment, while two other patients had minimal involvement of lymphoma cells which was recognized only by EBV in situ hybridization (2/40, 5%). Two patients had a disseminated disease at diagnosis and died 6 days and 214 days after diagnosis. One patient had diffuse colonic lesion and died 82 days later. In conclusion, marrow involvement in nasal NK/T cell lymphoma is infrequent at initial diagnosis, and EBV ISH is a useful technique for identifying the minor subgroup of patients which have easily overlooked neoplastic involvement.

Show MeSH
Related in: MedlinePlus