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The distribution of fetal nuchal translucency thickness in normal Korean fetuses.

Chung JH, Yang JH, Song MJ, Cho JY, Lee YH, Park SY, Moon MJ, Lim HJ, Choi JS, Kim JO, Shin JS, Ahn HK, Han JY, Kim MY, Choi KH, Ryu HM - J. Korean Med. Sci. (2004)

Bottom Line: Among them, a total of 2,577 fetuses with a known normal outcome were included in this study.Therefore, a fixed cut-off point through the first trimester was not appropriate and each NT measurement should be examined according to the gestational age.The present study offers normative data of the fetal NT thickness in a Korean population, which can be used as reference for screening chromosomal aberrations or other congenital abnormalities in the first trimester.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.

ABSTRACT
The aim of present study was to establish normative data for the distribution of nuchal translucency (NT) thickness in normal Korean fetuses. The data were collected from pregnant women with singleton pregnancies in whom fetal ultrasound was performed and the fetal NT thickness was measured between 11 and 14 weeks of gestation. Among them, a total of 2,577 fetuses with a known normal outcome were included in this study. The distribution of multiple of median (MoM) values of the NT thickness with crown-rump length (CRL) in 10-mm intervals and the 95th percentile of MoM were calculated with the linear regression method. The present study showed that NT measurements increase with increasing CRL and a false positive rate increases with increasing gestational age. Therefore, a fixed cut-off point through the first trimester was not appropriate and each NT measurement should be examined according to the gestational age. The present study offers normative data of the fetal NT thickness in a Korean population, which can be used as reference for screening chromosomal aberrations or other congenital abnormalities in the first trimester.

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The distribution of nuchal translucency (NT) thickness in normal fetuses with crown-rump length.
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Figure 2: The distribution of nuchal translucency (NT) thickness in normal fetuses with crown-rump length.

Mentions: Fig. 2 plots the distribution and the 5% and 95%, lower and upper limits of NT thickness according to the simple linear regression. NT thickness increased with CRL estimates of gestational age. The regression equation relating median NT thickness to CRL was described as follows: expected NT thickness (mm)=0.437+0.01969×CRL (mm) (R2=0.127, p<0.001).


The distribution of fetal nuchal translucency thickness in normal Korean fetuses.

Chung JH, Yang JH, Song MJ, Cho JY, Lee YH, Park SY, Moon MJ, Lim HJ, Choi JS, Kim JO, Shin JS, Ahn HK, Han JY, Kim MY, Choi KH, Ryu HM - J. Korean Med. Sci. (2004)

The distribution of nuchal translucency (NT) thickness in normal fetuses with crown-rump length.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822260&req=5

Figure 2: The distribution of nuchal translucency (NT) thickness in normal fetuses with crown-rump length.
Mentions: Fig. 2 plots the distribution and the 5% and 95%, lower and upper limits of NT thickness according to the simple linear regression. NT thickness increased with CRL estimates of gestational age. The regression equation relating median NT thickness to CRL was described as follows: expected NT thickness (mm)=0.437+0.01969×CRL (mm) (R2=0.127, p<0.001).

Bottom Line: Among them, a total of 2,577 fetuses with a known normal outcome were included in this study.Therefore, a fixed cut-off point through the first trimester was not appropriate and each NT measurement should be examined according to the gestational age.The present study offers normative data of the fetal NT thickness in a Korean population, which can be used as reference for screening chromosomal aberrations or other congenital abnormalities in the first trimester.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.

ABSTRACT
The aim of present study was to establish normative data for the distribution of nuchal translucency (NT) thickness in normal Korean fetuses. The data were collected from pregnant women with singleton pregnancies in whom fetal ultrasound was performed and the fetal NT thickness was measured between 11 and 14 weeks of gestation. Among them, a total of 2,577 fetuses with a known normal outcome were included in this study. The distribution of multiple of median (MoM) values of the NT thickness with crown-rump length (CRL) in 10-mm intervals and the 95th percentile of MoM were calculated with the linear regression method. The present study showed that NT measurements increase with increasing CRL and a false positive rate increases with increasing gestational age. Therefore, a fixed cut-off point through the first trimester was not appropriate and each NT measurement should be examined according to the gestational age. The present study offers normative data of the fetal NT thickness in a Korean population, which can be used as reference for screening chromosomal aberrations or other congenital abnormalities in the first trimester.

Show MeSH
Related in: MedlinePlus