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A case of Hodgkin's lymphoma associated with sensory neuropathy.

Oh BC, Lim YM, Kwon YM, Khang SK, Kim KK - J. Korean Med. Sci. (2004)

Bottom Line: We report a patient with lymphoma whose chief complaint was a sensory loss in the hands and feet.Electrophysiologic studies and sural nerve biopsy showed sensory polyneuropathies.We hypothesize that this neuropathy is associated with lymphoma-related ganglionopathy, and among the possible causes, we suspect that a systemic cause such as a paraneoplastic syndrome is the most likely pathogenic etiology.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea.

ABSTRACT
Peripheral neuropathies occur in lymphoma patients. Causes of neuropathy include chemotherapy, opportunistic infections, and the lymphoma itself. We report a patient with lymphoma whose chief complaint was a sensory loss in the hands and feet. Electrophysiologic studies and sural nerve biopsy showed sensory polyneuropathies. We hypothesize that this neuropathy is associated with lymphoma-related ganglionopathy, and among the possible causes, we suspect that a systemic cause such as a paraneoplastic syndrome is the most likely pathogenic etiology. However, further follow-up will be necessary to see whether sensory symptoms change with lymphoma treatment.

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Sural nerve biopsy (modified Gomori trichrome stain, ×100). The sural nerve biopsy shows several myelin digestion chambers (arrow), suggesting axonal degeneration.
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Figure 3: Sural nerve biopsy (modified Gomori trichrome stain, ×100). The sural nerve biopsy shows several myelin digestion chambers (arrow), suggesting axonal degeneration.

Mentions: The sural nerve biopsy showed several myelin digestion chambers, suggesting axonal degeneration on modified Gomori stain (Fig. 3). There was no evidence of vasculitis or inflammatory neuropathy. There was no neoplastic lymphoid cell infiltration of the sural nerve. On electron microscopy, the sural nerve showed the loss of small and large myelinated fibers with axonal sprouting and myelin ovoids, suggesting an axonal neuropathy (Fig. 4).


A case of Hodgkin's lymphoma associated with sensory neuropathy.

Oh BC, Lim YM, Kwon YM, Khang SK, Kim KK - J. Korean Med. Sci. (2004)

Sural nerve biopsy (modified Gomori trichrome stain, ×100). The sural nerve biopsy shows several myelin digestion chambers (arrow), suggesting axonal degeneration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2822249&req=5

Figure 3: Sural nerve biopsy (modified Gomori trichrome stain, ×100). The sural nerve biopsy shows several myelin digestion chambers (arrow), suggesting axonal degeneration.
Mentions: The sural nerve biopsy showed several myelin digestion chambers, suggesting axonal degeneration on modified Gomori stain (Fig. 3). There was no evidence of vasculitis or inflammatory neuropathy. There was no neoplastic lymphoid cell infiltration of the sural nerve. On electron microscopy, the sural nerve showed the loss of small and large myelinated fibers with axonal sprouting and myelin ovoids, suggesting an axonal neuropathy (Fig. 4).

Bottom Line: We report a patient with lymphoma whose chief complaint was a sensory loss in the hands and feet.Electrophysiologic studies and sural nerve biopsy showed sensory polyneuropathies.We hypothesize that this neuropathy is associated with lymphoma-related ganglionopathy, and among the possible causes, we suspect that a systemic cause such as a paraneoplastic syndrome is the most likely pathogenic etiology.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea.

ABSTRACT
Peripheral neuropathies occur in lymphoma patients. Causes of neuropathy include chemotherapy, opportunistic infections, and the lymphoma itself. We report a patient with lymphoma whose chief complaint was a sensory loss in the hands and feet. Electrophysiologic studies and sural nerve biopsy showed sensory polyneuropathies. We hypothesize that this neuropathy is associated with lymphoma-related ganglionopathy, and among the possible causes, we suspect that a systemic cause such as a paraneoplastic syndrome is the most likely pathogenic etiology. However, further follow-up will be necessary to see whether sensory symptoms change with lymphoma treatment.

Show MeSH
Related in: MedlinePlus